Nature Communications
Articles in this Issue
Manipulating electrolyte solvation structures to build high-voltage concentration batteries for efficient energy storage
Crossed laser phase plates for transmission electron microscopy
Abstract A phase plate has long been sought in transmission electron microscopy (TEM) to maximize the image contrast of weakly-scattering objects like biomolecules. The laser phase p...
Chiral emission from chirotopic nanostructures
Optimal blood pressure target in patients with uncomplicated hypertension: a target trial emulation study
Abstract The limited real-world evidence on the clinical benefits of intensive blood pressure (BP) management demonstrated in randomised controlled trials has led to its poor adoptio...
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Abstract Integrin adhesion complexes mediate dynamic cell-matrix interactions to regulate cell adhesion, migration and invasion. While increasing evidence suggests that adhesion comp...
Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor
Abstract Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that deacetylates non-histone substrates such as α-tubulin and cortactin. HDAC6 contains two catalytic domains, each co...
TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites
Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits
A pegivirus associated with encephalitis in red-legged partridges shows neurotropism across avian species
Abstract Pegiviruses are generally regarded as non-pathogenic viruses with controversial clinical significance. Here, we describe an avian pegivirus (partridge p...
Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis
Atypical B cells and inflammatory profiles delineate immunity to influenza vaccination in First Nations and non-Indigenous people with chronic multimorbidity
Abstract Indigenous people are disproportionately impacted by influenza viruses and chronic multimorbidity. Yet, the impact of comorbidities on immunity towards...
AMC-F1 regulates mitochondria-autophagy crosstalk independent of nutrient stress
Gate-tunable giant negative magnetoresistance in tellurene driven by quantum geometry
Abstract Negative magnetoresistance in conventional two-dimensional electron gases is a well known phenomenon, but its origin in complex and topological material...
A chemoproteomic atlas of the human purine interactome for regioselective ligand discovery
Stress granule phase separation in stress-responsive cytosolic extract-in-oil droplets
Abstract Stress granules (SGs) are biomolecular condensates that form transiently in the cytosol of mammalian cells in response to stress. Dysregulation of their assembly or disassem...
Asymmetric alloying for heterogeneous metal-ion clusters of chiral-at-carbon CAuI4AgI6 polyhedra exhibiting red to near-infrared photoluminescence
Li-In-S composite foil with built-in electric fields to stabilize Li/Li6PS5Cl interface for long-life all-solid-state batteries
Quantification of molar sub-regions suggests increasing herbivory during primate origins
Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice
Abstract Microglia play crucial roles in Alzheimer’s disease (AD), yet the molecular mechanisms are unclear. Here, we show that CD31, a recognized endothelial marker, is predominantl...
Precision timekeeping with atomic clocks: evolution and future directions
All-water supercapacitor enabled by 1-nm clay channels
Abstract Water confined to channels one nanometer thick exhibits electrochemical behavior distinct from bulk water, including enhanced protonic conductivity and...
HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack
Abstract Cytotoxic lymphocytes use perforin to form plasma membrane (PM) pores in tumor cells, thereby enabling granzyme-mediated cell death. However, whether and how tumor metabolis...
Mycobacterium tuberculosis transmission from tuberculosis patients with and without recognized symptoms: a case-contact study in eastern China
Scalable Boltzmann generators for equilibrium sampling of large-scale materials
Abstract Generating equilibrium ensembles of structures is essential for modeling molecules and materials, yet traditional simulators like molecular dynamics suffer from limited samp...
Economic specialization and heterogeneous temperature-economy relationships suggest net costs of climate change in Europe
Abstract Econometric studies of temperature and GDP imply that warming harms hot countries, benefits cool ones, and that a single globally optimal temperature exists. We show that su...