Nature Communications
Articles in this Issue
Observation of anomalous decay of a polarized three-component Fermi gas
Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis
Abstract Bipolar disorder (BD) is a major global health burden, and its treatment challenges highlight the need for pathology-based therapeutic development. Emer...
Automatic optimization of flat-field corrections by evaluation and enhancement (EVEN) in multimodal optical microscopy
Abstract Uneven illumination affects all images acquired by optical microscopes, especially large, multicolour and nonlinear measurements. Although removal is possible with various a...
Brain and neural cell type proteomics reveal extracellular matrix proteins enriched in progressive multiple sclerosis
Perpendicular neuromorphic channels facilitate lateral inhibition for tactile location
Highly efficient expression of DNA-peptide conjugates in growth-arrested cells
Abstract Efficient nuclear delivery of DNA remains a major challenge in non-viral gene therapy. While nuclear localization signal (NLS) peptides have been explor...
Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment
Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase
Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer
Bayesian teaching enables probabilistic reasoning in large language models
Boosting superconductivity in ultrathin YBa2Cu3O7−δ films via nanofaceted substrates
Abstract In cuprate high-temperature superconductors the doping level is fixed during synthesis, hence the charge carrier density per CuO 2...
Efficacy and safety of cAMP signalling-biased GLP-1 analogue ecnoglutide monotherapy versus placebo in patients with type 2 diabetes (EECOH-1): a multi-centre, randomised, double-blind, placebo-controlled, phase 3 trial
Abstract Ecnoglutide is a cAMP-biased GLP-1 analogue developed for the treatment of type 2 diabetes mellitus (T2DM) and obesity. We conducted a randomised, doubl...
Cell wall pectin reshapes leaf drought tolerance in dry forests
A Machine Learning-Driven Electrophysiological Platform for Real-Time Tumor-Neural Interaction Analysis and Modulation
Abstract Neural-tumor electrophysiology—marked by pathological membrane potentials and ion channel dysregulation—emerges as actionable targets to curb tumor aggression. Yet, how neur...
Self-assembled lyotropic liquid crystal interlayer regulated interfacial polymerization for modulating structure and performance of nanofiltration membranes
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations
Abstract Glioblastoma (GBM) remains the most common and lethal adult malignant primary brain cancer with few treatment options. A significant issue hindering GBM...
Tau condensation on DNA mediates microtubule attachment suggesting a mitotic role for centromere-localized tau
DNA actively regulates the “safety-belt” dynamics of condensin during loop extrusion
Tetrachloromethane as an editable all-carbon quaternary source
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis
Coastal flood impacts and lost ecosystem services along Europe’s outermost regions and overseas countries and territories
Abstract Climate change is expected to result in rising seas, exacerbating coastal floods and erosion. Remote islands are projected to be among the most challeng...
Tumor agnostic drug delivery with dynamic nanohydrogels
Refrigeration down to 0.16 K using a frustrated magnet Gd2B2MoO9
The inflammatory path toward type 1 diabetes begins during pregnancy
Abstract Type 1 diabetes (T1D) is increasing globally, yet the earliest biological determinants remain poorly defined, particularly in general population studies. We studied the Swed...
Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones
Abstract Lipid nanoparticles (LNPs) efficiently deliver nucleic acids to cells in vivo and facilitate clinical applications including RNA-based vaccines and therapies. Discovery and...