Nature Communications
Articles in this Issue
HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation
Abstract Hexim proteins are key RNA-dependent regulators of eukaryotic transcription through 7SK-dependent sequestration and inactivation of the kinase P-TEFb (Cdk9–CyclinT1/2) in th...
Inferring chromatin architecture at a single locus through probabilistic in situ DNA localization
Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals
Abstract Low-valent sulfur-containing compounds are abundant among natural and synthetic products but remain underutilized as starting materials in desulfurative transformations. Her...
Reducing bulky medical images via shape-texture decoupled deep neural networks
Brain-gonad axes harmonize male mating drive and reproductive strategy via steroid hormones
Tmem110 regulates the conformation of TRPML1 to maintain endolysosomal homeostasis and prevent mitochondrial DNA leakage and pathological self-DNA processing
Robust water-activated tissue adhesive patch for arterial/heart wound closure after intervention surgery
Assembling unregulated DNA segments bypasses synthesis screening: regulate fragments as select agents
Genetic and non-genetic factors distinctly shape the variation of the immune response in cattle
Structure of a Brochothrix thermosphacta bacteriophage reveals cell wall adsorption mechanism in Gram-positive infecting siphophages
Distributed multitudes of bio-inspired, biodegradable Lagrangian sensors for environmental sustainability
H3K27me3-dependent imprinting and transcriptional regulation in early mouse embryos requires EZHIP-mediated restriction of PRC2 activity
Asynchrony and functional diversity couple herbivore community dynamics to host plant diversity
Abstract Biodiversity loss can destabilize ecosystem functioning. How biodiversity–stability relationships are interlinked across trophic levels remains poorly investigated, however,...
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility
Reducibility of higher-order networks from dynamics
Abstract Empirical complex systems can be characterized not only by pairwise interactions, but also by higher-order (group) interactions influencing collective phenomena, from metabo...
Selective electrosynthesis of urea from nitrate and carbon dioxide with low overpotential
Tailoring polarization homogeneity in discontinuous-columnar Bi(Fe,Mn)O3 thin films via dislocation engineering with controlled self-assembly
OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells
Abstract DNA replication initiates at specific genomic regions known as initiation zones (IZs), which follow a defined spatiotemporal program that is partially dependent on cell type...
Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
Abstract Ubiquitin modifications regulate fundamental cellular activities by modulating protein stability and function. The ubiquitin ligase COP1, which is prese...
Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion
Control of telomerase recruitment and end protection by independent shelterin components
Abstract Telomeres are proposed to alternate between “closed” states, in which chromosome ends are protected from DNA damage signaling and inaccessible to telomerase, and “open” stat...
Light-driven restructuring generates nanoisland NiIr alloy for efficient methane dry reforming
A high-throughput, flow cytometry approach to measure phase behavior and exchange in biomolecular condensates
Abstract Biomolecular condensates are essential for cellular organization, yet their formation dynamics and molecular content exchange properties remain poorly understood. Here we sh...