Nature Communications
Articles in this Issue
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults
Mitophagy promotes lung repair and regeneration by restoring epithelial metabolic fitness
Metal-metal interactions in catalysis from spatial separation to physical mixtures
Abstract Physical mixtures of segregated metals recently demonstrated enhanced activity in redox reactions by assigning specific elementary steps to distinct sites to close the catal...
Rational design of a Kappa opioid receptor peptide agonist with attenuated β-arrestin signaling
Abstract Difelikefalin is an FDA-approved κ-opioid receptor (KOR) peptide agonist used to treat chronic pruritus. However, as a balanced agonist that activates b...
Phage-assisted evolution of allosteric protein switches
Abstract Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation. Artificial allosteric effectors...
Potent acridone antimalarial against all three life stages of Plasmodium
Abstract Antimalarial therapeutics ideally should target all three major Plasmodium life cycle stages. Here we present an...
Early life exposure to N-nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice
Hi-Compass: a depth-aware deep learning framework for predicting cell-type-specific 3D genome organization from single-cell to spatial resolution
Abstract Three-dimensional genome organization controls cell-type-specific gene expression through chromatin interactions, yet systematic analysis across diverse cellular contexts re...
Phonon-scattering-induced linear magnetoresistance in the quantum limit up to room temperature
A molecular framework of the Rht-A1–TaLA1-D module controlling tiller angle in wheat
Topological isomerization unlocks exceptional elasticity and strength of cellulosic triboelectric aerogels
Dual-function surface engineering for enhancing anode stability in alkaline seawater oxidation
Insects manipulate host nuclear trafficking and epigenetic regulation to facilitate herbivory
Significant Southern Hemisphere contribution to the Indonesian Throughflow over the last 800,000 years
Abstract The low-latitude flow of water masses from the Pacific to the Indian Ocean, the Indonesian Throughflow (ITF), is a choke point of the surface ocean retu...
Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion
Sparseness facilitates image encoding across visuo-frontal networks in freely moving macaque
A multi-modal diffusion model with dual-cross-attention for multi-omics data generation and translation
Revealing the hidden third dimension of point defects in two-dimensional MXenes
Abstract Point defects govern many important functional properties of two-dimensional (2D) materials. However, resolving the three-dimensional (3D) arrangement o...
Oxidation-reconstructed Li+ transport enables high-tap-density single-crystal regeneration of spent LiNi0.5Co0.2Mn0.3O2 positive electrodes
High-resolution cryo-EM structures of small protein–ligand complexes near the theoretical size limit
Carbon monoxide oxidation expands the known metabolic capacity in anaerobic methanotrophic consortia
Carbon monoxide metabolism in freshwater anaerobic methanotrophic archaea
Abstract Anaerobic methanotrophic archaea mitigate methane emissions in anoxic environments as key members of the biological methane filter. Despite their ecolog...
Strain‒induced spin regulation of stepped Co(111) for boosting peracetic acid magnetocatalysis
Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula
Abstract Brain regions that integrate multiple types of information (“convergence zones”) are crucial for the brain to generate coherent experiences and behavior...