Nature Communications
Articles in this Issue
Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA
Abstract The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with resistance to cancer and hypoxia, suggest...
Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase
Abstract Formation of the activated human spliceosome (B act ) involves major structural rearrangements, leading to the c...
High-sensitive glycomics using seGRAP-mass spectrometry uncovers a conserved N-glycome in single human oocytes
Molecular architecture of heterochromatin at the nuclear periphery of primary human cells
Abstract In eukaryotes, meters of DNA are packaged into micrometer scale nuclei. Nucleosomes, as the major organizational unit, have been extensively studied in vitro, yet the elabor...
PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Abstract Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely u...
Multitrophic interaction networks mediate biodiversity effects on ecosystem multifunctionality
Abstract Biodiversity loss threatens the multifunctionality of ecosystems on which human well-being ultimately depends. Multitrophic species interactions may be key to explaining the...
Dissecting autonomous enzymatic variability in single cells
Abstract Metabolic enzymes perform life-sustaining functions in various cellular compartments. Anecdotally, metabolic activity is observed to vary between genetically identical cells...
Years of life lost in patients with a false-negative diagnosis of primary melanoma. A prospective study of the German Central Malignant Melanoma Registry involving 9063 patients over 28 years
Abstract A false-negative diagnosis of cancer can lead to a delay in effective treatment and a poorer prognosis. Here, we use the example of cutaneous melanoma to examine how many ye...
Near-unity charge readout signal in a nonlinear resonator without matching the sensor dissipation
Abstract Dissipative sensors typically use linear resonators with impedance matching to achieve maximal signal and fast operation. The impedance matching, however, sets an upper limi...
Comparative analysis of Cdc48-dependent proteolysis at the ER, mitochondria and chloroplasts
Abstract The ubiquitin-proteasome system (UPS) is the preeminent proteolytic system in eukaryotes. While soluble nucleocytosolic proteins are readily accessed by the UPS, organelle-l...
Portable, real-time 3D ultrasound for operator-independent breast imaging
Publisher Correction: Divergent multifunctional P450s-empowered biosynthesis of bioactive tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution
A molten salt metal-air electrolyzer for recycling superalloy
Achieving near-theoretical strength and high elasticity in micrometer scale TiB2 ceramics
Abstract Achieving near-theoretical strength and elastic limits in crystalline solids remains challenging, yet defect sensitivity typically restricts such behavi...
Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis
Abstract Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzym...
A deep learning framework for efficient pathology image analysis
Abstract Artificial intelligence has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images. However, current methods are computationa...
Toughening elastomer via sequentially activated multi-pathway energy dissipation
Abstract Auxiliary energy dissipation pathways have been incorporated into elastomer design to enhance the toughness. However, most strategies involving multiple pathways rely on non...
Author Correction: Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes
Developmental timing distinguishes pediatric and adult cancers through retention and rewiring mechanisms
Abstract Oncogenic mutations can have fundamentally different consequences depending on the developmental state of the tissue in which they arise. We propose a unifying model in whic...
Graphitizable pitch from pine resin enables bulk graphite from terpenes
Author Correction: Charge transfer in triphenylamine–tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production
A sequential MAP kinase cascade regulates mechanical signalling
Abstract Plants respond to mechanical stimulations like wind, touching or wounding to safeguard their development and survival. Mitogen Activated Protein Kinases (MAPKs) activation b...
A carboxylate switch point controls long-range energy transduction in respiratory Complex I
Abstract Complex I is a highly intricate membrane-bound protein complex that powers the cellular energy metabolism by a long-range ( > 300 Å) proton-coupled e...
Zero-PDG silicon photonic amplifier with high saturation power and low noise figure
Abstract High-power amplifiers are of great importance in many optical systems deployed in optical sensing, ranging, medical surgery and more. Likewise, high-gain, low-noise amplifie...