Nature Communications
Articles in this Issue
Immune correlates of risk for SARS-CoV-2 infection in children: a prospective, community-based cohort study
Chemotherapy-induced senescence promotes stroma stiffness and antioxidant adaptation to promote chemoresistance in pancreatic ductal adenocarcinoma
Abstract Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) is partly driven by pathological stromal remodeling, yet the underlying mechanisms remain poorly understood. Here,...
Scale-bridging interface design enables high-performance sustainable thermoelectrics
Enhanced nuclear fusion in the sub-keV energy regime
Abstract Nuclear fusion requires overcoming or traversing a repulsive Coulomb barrier of hundreds of kiloelectronvolts, rendering the probability of fusion at sub-keV energies vanish...
Coordination electrochemistry taming reversible hypervalent bromine redox for energetic six-electron-transfer lithium-bromine battery
Abstract Conversion-type static bromine batteries demonstrate promise in high output voltage and large capacity for rechargeable energy storage due to the inhere...
Quasi-solitons in Rydberg atom chains
Abstract Solitons—localized wave packets that travel without spreading—play a central role in understanding transport and properties of nonlinear systems. In quantum many-body system...
β-arrestin recruitment facilitates a direct association with G proteins
Abstract G protein-coupled receptors (GPCRs) are targets for almost a third of all FDA-approved drugs. GPCRs are known to signal through both heterotrimeric G proteins and β-arrestin...
Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy
Highly Efficient Methane Electrosynthesis Enabled by Precise, Multifaceted Interface Regulation
High-yield visible-to-ultraviolet upconversion by ZnSe quantum dots with dynamic triplet transfer
Abstract Triplet–triplet annihilation upconversion sensitized by quantum dot is often limited by the short exciton lifetime, necessitating tethered triplet transmitter. Here, we repo...
Flow matching for reaction pathway generation
Abstract Elucidating reaction mechanisms requires efficient generation of transition states (TSs) and products. Existing diffusion and sequence-based models acce...
Mediterranean outflow waters supply North Atlantic convection sites
Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions
Abstract In the mammalian host, Trypanosoma brucei proliferates as slender bloodstream forms before undergoing quorum-sen...
Compressive learning scaffolds higher-order network structure to enhance human knowledge acquisition
Extracellular matrix stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids
Abstract Regional epithelial lineages of the human respiratory system reside within an extracellular matrix (ECM) whose mechanics vary along the airway–alveolar axis, yet how ECM sti...
Sulfotransferase signaling sustains fibroblast identity and antagonizes therapeutic cardiac reprogramming
CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk
Abstract Mechanisms linking CD33 variants to Alzheimer Disease (AD) are poorly defined. Here, we combine structural, cellular, and genetic analyses to delineate...
Visualizing excitonic states in constructed cyclic molecular architectures by tip-enhanced photoluminescence
Convergent nuclear proteostasis alterations across 40S ribosomal protein deficiencies
Misregulation of T-box transcription factors drives BNP–NPR1 signalling underlying chronic itch
Abstract Chronic itch poses a significant clinical burden, with activation of the brain natriuretic peptide (BNP) pathway as a hallmark, though its transcription...
Confidence-guided cryo-EM map optimisation with LocScale-2.0
Abstract Cryogenic sample electron microscopy (cryo-EM) maps often display uneven quality, with high-resolution features coexisting alongside weak or poorly ordered regions. Such var...
Mid-IR light modulators enabled by dynamically tunable ultra-high-Q silicon membrane metasurfaces
Abstract Metasurfaces enable subwavelength control of free-space light for applications in sensing, nonlinear optics, and quantum photonics. However, their pract...
Single-nucleus analysis of the adult human olfactory epithelium uncovers shared neurogenesis programs with the brain
Internalized components of membrane attack complexes disrupt proteostasis and acquire alarmin-like properties
Abstract Immune effects of membrane attack complexes (MAC) have been widely attributed to their abilities to cause cell death. Here, we show that the MAC component, C9, forms non-cyt...
Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1
Abstract The yeast RAD27 gene encodes the Rad27/Fen1 nuclease, which contributes to genome stability during Okazaki fragment maturation (OFM), DNA mismatch repai...