Journal of the American Chemical Society
Articles in this Issue
Rational Design of the Composite Perfluoro-Sulfonic Ionomer for High-Performance Proton Exchange Membrane Fuel Cells
Abstract Scaling proton exchange membrane fuel cells (PEMFCs) is constrained by high cathodic overpotential and platinum usage for the oxygen reduction reaction, challenges exacerbat...
Ti3+-O Acid–Base Pairs for Efficient Solar-Driven Photothermal Nonoxidative Ethane Dehydrogenation
Abstract Nonoxidative ethane dehydrogenation (NOEDH) is a carbon efficient but thermodynamically severe route for ethene production. Solar-driven NOEDH offers a promising alternative...
Total Synthesis of Benthol A: Evidence for a Structure Revision
Abstract Benthol A, a dinoflagellate-derived polyol/polyether marine natural product endowed with potent antimalaria and appreciable antiviral activity, consists of a 72 C atom linea...
Accelerated Self-Photopolymerization of Phenolics in Microdroplets Contributes to the Brown Carbon Formation
Abstract While phenolic compounds are recognized as key atmospheric precursors of brown carbon (BrC), the mechanisms governing their interfacial transformation into BrC aerosols, par...
Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes
Abstract ADP-ribosylation (ADPr), long recognized as a canonical protein post-translational modification, has recently expanded to include targeting nucleic acids, uncovering a diver...
Engineering Altermagnetic Transitions in Two-Dimensional Metal–Organic Frameworks via Chemical Symmetry Breaking
Abstract Altermagnets are symmetry-defined magnetic phases that combine momentum-dependent spin splitting with zero net magnetization, offering promising opportunities for spintronic...
Total Synthesis of Benthol A: The Nominal and the Actual Natural Product
Abstract The total synthesis of the dinoflagellate-derived “super-carbon-chain compound” benthol A rigorously confirmed what the analysis of one of the required building blocks had f...
Zero Indirect Band Gap and Flat Bands in a Niobium Oxyiodide Cluster Material
Abstract Explorative chemistry in a reaction system composed of NbI4, Li2(CN2), and Li2O has led to the discovery of a number of niobium oxyiodide cluster compounds. During this reac...
Influence of Halide Substitution on Local and Average Structure, Lattice Dynamics, and Transport Properties in Cu6PS5X Argyrodites
Abstract Halide-substituted argyrodite materials have attracted increasing attention for energy applications since compositional tuning provides an effective strategy to modulate the...
Understanding Electrochemical Alcohol Hydrogenolysis Enabled by Carbonyl Reduction in Lignocellulosic Biomass-Derived Aromatic Oxygenates
Abstract Molecules derived from lignocellulosic biomass are oxygenates with multiple oxygen-containing functional groups, such as hydroxyl and carbonyl groups. Therefore, the ability...
Facile Fabrication of Redox-Active Covalent Organic Frameworks via Reductive <i>N</i> -methylation
Abstract Redox-active covalent organic frameworks (COFs) are promising materials for electronics, sensing, and catalysis. However, their synthesis is hampered by the scarcity of redo...
In Situ Unveiling of the Coupling Mechanism of Intercalation-Conversion Processes at the Nanoscale in Lithium–Ion/Lithium–Oxygen Hybrid Batteries
Abstract With the rapid growth in energy demand, designing a novel hybrid battery system has become increasingly important. It is critical to reveal the coupling mechanisms of interc...
Multidomain Relaxation Dispersion NMR Resolves an Intermediate-Gated Binding Pathway for Selective Recognition of Linear Diubiquitin by HOIL-1L
Abstract Molecular recognition is governed not only by the structural complementarity of the final complex, but by the kinetic pathway through which it forms. Polyubiquitin chains, i...
Arraying Shape-Persistent Molecular Alkynyl Trap into Highly Porous and Robust Zirconium Metal–Organic Framework for Propyne Capture and Propyne/Propylene Separation
Abstract Adsorptive separation of propyne/propylene (C3H4/C3H6) using porous adsorbents offers a promising route toward energy-efficient production of polymer-grade C3H6. Currently,...
Dedioxygenative Phosphonylation of Carboxylic Acids
Abstract Dedioxygenative transformations of carboxylic acids are faced with the significant challenges in efficiently breaking multiple C–O bonds and achieving broad applicability ac...
Origins of Reactivity in SAM-Utilizing Ribozyme SAMURI-Catalyzed RNA Alkylation
Abstract Unlocking the design principles of programmable RNA catalysts capable of site-specific chemical modification is critical for expanding the functional and therapeutic potenti...
High-Pressure Investigation of the I–N System: Discovery of the Nitric Ozonide [N3]3– (“Ozonitride”) Species and Multicenter Bonding in Iodine Frameworks
Abstract Despite binary nitrides being heavily investigated at high pressures in the past decade, nitrogen halides are still a terra incognita at pressures exceeding 1 bar. Due to th...
Supramolecular Predisposition Promotes Intramolecular Heavy-Atom Effects for Self-Sensitized Oxidation
Abstract Supramolecular confinement is widely used to control molecular architecture, but its use to direct excited-state reaction pathways remains underexplored. This limitation is...
Spinterface-like Mechanism of the Chirality-Induced Spin Selectivity in Donor–Chiral Bridge–Acceptor Complexes
Abstract The chirality-induced spin selectivity (CISS) effect has been invoked to explain recent reports of differences in the time-resolved EPR signals between chiral and achiral mo...
Structural Chemistry of [V2As17]3– and [V2Sb17]4–: A Complex Interplay between V-Pn and Pn-Pn Bonding
Abstract The ability of the heavier pnictogen elements, P, As, Sb and Bi, to form extensively catenated structures is well established, and a wide range of architectures is known, bo...
Reprogramming ThDP Enzymes for <i>Z</i> -Alkenes: Overriding Thermodynamic Preference via Noncovalent Controls
Abstract Most conventional alkene synthesis reactions (e.g., elimination et al.) inherently favor the formation of thermodynamically more stable E-isomers, posing a long-standing cha...
Pulse-Driven Paired Electrosynthesis of Formamide via Redox-Tuned Intermediate Management
Abstract Renewable electricity-driven electrocatalytic systems hold promise for the sustainable formamide (HCONH2) synthesis. However, a major bottleneck remains the low Faradaic eff...
Efficient Synthesis of N-Bridged Annulenes
Abstract The most commonly encountered aromatic structure is the benzenoid ring, which is observed in a wide variety of pharmaceuticals and organic materials. However, studies on non...
Identifying Disordered Intermediates in the Reaction of Cu3– <i>x</i> P and Dibenzyl Diselenide to form Cu3PSe4 Nanoparticles
Abstract Developing a detailed understanding of ternary nanoparticle (TNP) formation is essential for their optimized rational synthesis and development of synthetic routes for new T...
Reaction Medium as an Architect of Nanocrystal Superlattices
Abstract Nanocrystal superlattices are commonly formed by changing concentration, solvent conditions, or particle surface chemistry. Although effective, these approaches alter multip...