Journal of Clinical Oncology
Articles in this Issue
Cancer genetics evaluation among individuals at risk for Lynch syndrome across all qualifying indications.
10616 Background: < 20% of individuals suspicious for Lynch syndrome (LS) and other inherited cancer syndromes undergo genetic testing in the US. Undia...
Overall survival according to timing of immune checkpoint inhibitors administration in patients with advanced cancer: Results from a large single-centre cohort analysis.
2662 Background: Immune checkpoint inhibitors (ICIs) have revolutionised cancer treatment but are only effective in a subset of patients. Evidence of a ci...
Economic burden of cytokine release syndrome in older adults and underserved populations: A Nationwide Inpatient Analysis (2019–2021).
e24097 Background: Cytokine release syndrome (CRS) is a potentially life-threatening complication of cancer immunotherapy with profound economic and clini...
Phase 1/2 clinical trial of JIN-A02, a 4th generation EGFR-TKI in EGFR-mutated advanced/metastatic non-small cell lung cancer.
TPS8650 Background: Epidermal growth factor receptor ( EGFR ) mutations are the predominant drivers of NSCLC. While EGFR tyrosine...
The first-in-human phase 1/2 study of TSN1611, a highly selective KRAS G12D inhibitor, in patients with advanced solid tumors.
3083 Background: TSN1611 is a novel small molecule KRAS G12D inhibitor targeting both active (GTP-bound) and inactive (GDP-bound) forms of KRAS G12D prote...
Efficacy of IFN-alpha-2b as adjuvant treatment for acral melanoma: A retrospective analysis of 113 cases in China.
e21558 Background: High-dose interferon-alpha-2b (HD-IFN) has an important place in the adjuvant treatment of acral melanoma (AM). However, studies on the...
Transforming oncology clinical trial matching through multi-agent AI and an oncology-specific knowledge graph: A prospective evaluation in 3,800 patients.
1554 Background: Clinical trial enrollment in oncology is often hampered by the manual, time-intensive process of matching patients to trials with highly...
Hypertension and VEGF-A level correlation in cancer patients starting VEGF inhibitors: A prospective study.
e16543 Background: Vascular endothelial growth factor inhibitors (VEGFi) are commonly used in cancer therapy. VEGFi can cause hypertension by interference...
Why the duration of cancer treatment requires a closer look: An empirical analysis of recent FDA approvals.
11022 Background: The duration of cancer treatment directly impacts its efficacy, toxicity, and cost. Yet, its systematic evaluation is missing in most cl...
Results of combined therapy with pemetrexed and carboplatin in progressive ovarian cancer.
e17598 Background: In the structure of overall oncological morbidity in Uzbekistan, ovarian cancer ranks 7th, with an incidence rate of 2.9 per 100,000 po...
Overcoming barriers to colorectal cancer screening and research enrollment by minoritized and underinsured populations.
e13758 Background: The Texas Cancer Interception Institute (TCII) encourages participation in early detection initiatives, regardless of socioeconomics or...
Prognostic factors of survival and recurrence after liver transplantation for unresectable colorectal liver metastases: Results from the TransMet trial.
3561 Background: Liver transplantation (LT) has recently proved to improve the survival of selected patients with unresectable colorectal liver metastases...
Sociodemographic disparities among patients referred externally for clinical trials in a large community oncology setting.
e13756 Background: The vast majority of patients with cancer are seen in community oncology settings, yet enrollment onto clinical trials –which are prima...
Impact of declining renal function on multiple myeloma (MM) mortality in the U.S. (1999-2023): A regression analysis using the CDC WONDER database.
e19570 Background: MM often leads to renal complications, including acute kidney injury (AKI) and chronic kidney disease (CKD), requiring dialysis and inc...
Effect of a promising autologous therapeutic cancer nanovaccine on tumor associated macrophages for augmented lung cancer immunotherapy.
e14641 Background: Autologous cancer vaccines hold significant promise in personalized cancer immunotherapy; however, their clinical application is hinder...
Trends and disparities in lung cancer and respiratory failure mortality in the US: A 24-year retrospective study.
e20629 Background: Lung cancer (LC) and respiratory failure (RF) are major contributors to mortality in adults globally. Understanding long-term mortality...
Phase I multicenter, open-label, dose escalation study of T-1201, a small molecule drug conjugate, to assess safety, pharmacokinetics, and antitumor activity in advanced solid tumors.
TPS3162 Background: Phosphatidylserine (PS) is a phospholipid critical for maintaining cell membrane integrity and functionality. In rapidly proliferating...
A phase II study of NALIRIFOX (liposomal irinotecan, 5-fluorouracil, leucovorin and oxaliplatin) in patients with locally advanced pancreatic cancer (LAPC).
e16447 Background: Surgical resection is the only curative option for pancreatic cancer, but nearly 30% of patients (pts) present with locally advanced pa...
SWOG S2302, PRAGMATICA-LUNG: A pragmatic trial designed to increase participant representation.
11016 Background: Effective therapy following frontline immune checkpoint inhibitor (ICI)-based treatment for advanced non-small cell lung cancer (NSCLC)...
Risk of fracture following androgen receptor pathway inhibitors (ARPIs): A population-based study.
11164 Background: Androgen deprivation therapy is associated with an increased risk of fracture. ARPIs are widely used to manage advanced prostate cancer...
The SURVIVE study: Standard surveillance vs. intensified liquid biopsy-based surveillance in early breast cancer survivors.
TPS621 Background: Current breast cancer (BC) follow-up relies on clinical examinations and breast imaging, as studies from the 1980s demonstrated no surv...
21-gene expression assay in postpartum vs non-postpartum breast cancer and correlation with outcomes in young women with breast cancer.
e12538 Background: The incidence of breast cancer (BC) in young women is rising and noted for more aggressive features and worse prognosis. Concurrently,...
Nanoemulsions loaded with 5-fluorouracil and curcumin as a strategy for enhancing anticancer activity in FaDu cells for treating oral cancer.
e18035 Background: 5-fluorouracil (5-FU), a chemotherapeutic agent, and curcumin (Cur), a natural antioxidant, offer a broad pharmacological window for tr...
Predictive value of the triglyceride-glucose index for the efficacy of immunotherapy in patients with advanced NSCLC: A retrospective study.
e20583 Background: The expression programmed cell death ligand 1(PD-L1) couldn’t exactly predict the efficacy of immune checkpoint inhibitors (ICIs) in pa...
Development and validation of an AI-enabled prediction of prostate cancer (PCa) using urine-based liquid biopsy.
3080 Background: Prostate cancer (PCa) remains a major cause of malignancy-related mortality among men. Current diagnostic techniques, including PSA testi...