Journal of Clinical Oncology
Articles in this Issue
Exploring survivorship care coordination between primary care providers and cancer care clinicians.
e13873 Background: Survivors are at an increased risk of recurrence, subsequent primary cancers, comorbidities, physical and psychosocial long-term and la...
Desmoplastic nodular medulloblastoma: A National Cancer Database analysis of patient demographics and survival.
e14041 Background: Desmoplastic/nodular medulloblastoma (DNMB) is a subtype of primary brain tumor characterized by its distinctive nodular architecture a...
Investigating survival in patients undergoing surgery for pancreatic ductal adenocarcinoma using liquid biopsy: Preliminary results of PAN-CGE-BLISS pilot study.
e16454 Background: Analysis of cell-free DNA (cfDNA) is an alternative approach to conventional tumor markers in monitoring solid tumors. Although promisi...
Real-world findings from a multi-institutional quality study using CFIR to explore gaps, challenges, and opportunities around implementing precision medicine in community cancer settings.
e23157 Background: Precision medicine holds promise for improving cancer care, yet significant challenges persist in implementing multigene NGS testing an...
Trends in laryngeal cancer incidence and mortality: A comprehensive analysis of long-term and recent patterns with demographic disparities using Surveillance, Epidemiology, and End Results (SEER) data.
e18072 Background: Laryngeal cancer, primarily linked to smoking and alcohol consumption, has exhibited changing trends in incidence and mortality over th...
Assessment of age in the clinical risk stratification of patients with IDH-mutant gliomas.
2058 Background: Prognosis for mutant isocitrate dehydrogenase (mIDH) gliomas is influenced by tumor type, size, neurologic deficits, and age. Traditional...
PD1 inhibitors with concomitant palliative radiotherapy for treatment of older patients with locally advanced or metastatic cutaneous squamous cell carcinoma: Experience from a single centre in the United Kingdom.
e21569 Background: Cutaneous squamous cell carcinoma (cSCC), a common disease among older individuals, is particularly challenging to manage with traditio...
Impact of obesity and metabolic syndrome on survival in acute promyelocytic leukemia: A real-world analysis.
e18526 Background: The prevalence of obesity and metabolic syndrome (MetS) continues to rise, necessitating a deeper understanding of their implications f...
Phase I dose escalation trial of STX-001, an LNP-encapsulated self-replicating mRNA expressing IL-12, in patients (pts) with advanced solid tumors.
9556 Background: STX-001 is a lipid nanoparticle-encapsulated self-replicating mRNA that activates innate immunity, promot...
Molecular and immune profiling of breast cancer from pregnancy to postpartum: Insights into the tumour-immune landscape during breastfeeding from GEICAM EMBARCAM study.
530 Background: Breast cancer (BC) is the most common malignancy among young women of childbearing age, with a rising incidence in this population. Pregna...
Inhaled KB707, a novel HSV-based immunotherapy, as a monotherapy in patients with advanced solid tumor malignancies affecting the lungs: Efficacy and safety results from a phase 1/2 study.
2575 Background: The development of potent anti-tumor cytokines has been hindered by the systemic toxicity of intravenous administration. KB707 is a novel...
Two decades of change: Tracking intrahepatic cholangiocarcinoma mortality in the United States from 1999 to 2020.
e16197 Background: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy, recognized for its uncommon yet highly aggres...
Real-world evidence on the efficacy of atezolizumab and bevacizumab in unresectable hepatocellular carcinoma: An institutional experience.
e14594 Background: The incidence and mortality rates of primary liver malignancies continue to rise, with hepatocellular carcinoma (HCC) being the most pr...
Prostate cancer in HIV versus non-HIV population: Nationwide analysis of mortality, demographics, and healthcare utilization.
e17010 Background: Prostate Cancer (PC) is the most common non-skin cancer and the 4th leading cause of cancer related deaths amongst men in the United St...
BC3195, a novel ADC targeting cadherin-3 (CDH3): Updated results of a first-in-human phase I study in patients with advanced solid malignancies.
3019 Background: Cadherin-3 (CDH3), a calcium-dependent cell-cell adhesion glycoprotein, is overexpressed on lung, breast, head and neck and other maligna...
Efficacy of third-line and later (3L+) therapies post poly (ADP-ribose) polymerase inhibitor (PARPi) exposure in recurrent platinum-sensitive ovarian cancer (PSOC): A pooled clinical trial database analysis.
5579 Background: Patients (pts) with PSOC often experience reduced efficacy and tolerability with each successive treatment (tx). While PARPi therapies ha...
Treatment patterns and clinical outcomes with platinum-based chemotherapy after enfortumab vedotin and pembrolizumab in patients with metastatic urothelial carcinoma.
4573 Background: Enfortumab vedotin and pembrolizumab (EV/P) emerged as the new standard of care for previously untreated metastatic urothelial carcinoma...
Clinical validation of different HRD assays in high-grade serous ovarian cancer in Greek population.
e17591 Background: Homologous recombination deficiency (HRD) - encompassing presence of BRCA1/2 mutations and/or genomic instability (GIS) - is an establi...
Incidence, proportion and survival of stage IV breast cancer between 2010-2021.
e13041 Background: Breast cancer (BC) incidence is increasing. However, trends in incidence and proportion of de novo stage IV BC are underreported. Knowi...
Association between wildfire-dominated PM <sub>2.5</sub> exposure and non-small cell lung cancer survival in California.
10520 Background: Wildfire emissions include hazardous constituents, including fine particulate matter ≤2.5 μm in diameter (PM 2.5...
The tumor microenvironment in cholangiocarcinoma: Impact of natural killer cells on overall survival.
e16331 Background: Cholangiocarcinoma (CCA) describes a malignancy originating from the epithelial cells of the bile ducts. While rare, this malignancy of...
Cardiac adverse events with PARP inhibitors: Real world pharmacovigilance study using FAERS database.
e24011 Background: Poly(ADP-ribose) polymerase inhibitors (PARPi) effectively target BRCA1/BRCA2-mutated tumors by exploiting dysfunctional homologous rec...
Impact of COVID-19 infection on CAR-T therapy outcomes.
e23329 Background: CAR T-cell therapy has revolutionized the treatment of hematologic malignancies, offering a highly effective immunotherapy option. Howe...
Role of proliferation-related genes as predictive factors for adjuvant therapy in colon cancer.
e15664 Background: Adjuvant Therapy (AT) is recommended in colon cancer (CC) to enhance surgical cures, by few percentages, typically in node positive sta...
Amivantamab for recurrent/metastatic adenoid cystic carcinoma: A multicenter, single-arm, phase 2 clinical trial.
6101 Background: Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer with heterogenous clinical behavior. ACC typically presents with locoregio...