Journal of Clinical Oncology
Articles in this Issue
Evaluating the role of C-reactive protein and procalcitonin in risk stratification and outcomes of febrile neutropenia in solid malignancies.
e24080 Background: C-reactive protein (CRP) and procalcitonin (PCT) are widely used during inpatient admissions for febrile neutropenia (FN). However, nei...
Single cell characterization of uterine carcinosarcoma and analysis of transcriptomic shifts in tumor-associated macrophages in metastatic and chemotherapy-treated tumors.
e17615 Background: Uterine carcinosarcoma (UCS) is a rare gynecologic malignancy that has poor clinical outcomes and few targeted therapies. This aggressi...
DAREONTM-9, a phase Ib study of obrixtamig plus topotecan in patients (pts) with advanced small cell lung cancer (SCLC): Interim analysis results.
8094 Background: Delta-like ligand 3 (DLL3) is highly expressed on SCLC cells and is a promising target for new therapeutic drugs. Obrixtamig (BI 764532)...
Trick-MCC: Final results from the proof-of-concept investigator-initiated study of combination therapy with anti–PD-1, anti–LAG-3, and anti–TIM-3 in participants with advanced or metastatic PD-(L)1 refractory Merkel cell carcinoma (NCT06056895).
9531 Background: Merkel cell carcinoma (MCC) is an aggressive and highly immunogenic skin cancer associated with the Merkel cell polyomavirus. Over 50% of...
Development and status of medical oncology in China (De-SMOG): A nationwide questionnaire-based survey.
e23119 Background: The growing cancer burden in China necessitates ongoing enhancements in cancer management. Medical oncology is a pivotal component of c...
Dabrafenib and trametinib vs anti-PD(L)1 for the adjuvant treatment of locally advanced BRAF-mutant melanoma: A systematic review and meta-analysis.
e21566 Background: Both Dabrafenib and Trametinib (D+T) and Anti-PD(L)1s, such as Nivolumab and Pembrolizumab, have been shown to improve recurrence-free...
Modifiable risk-factors, genetic characteristics, and survival in early-onset cholangiocarcinoma.
4085 Background: Cholangiocarcinoma (CC) is a rare disease with an increasing incidence among younger adults, which is poorly understood. Genomic profilin...
Identification of differential epigenetic landscapes in subtypes of appendiceal cancer.
4199 Background: Appendiceal cancers (AC) represent a rare and heterogeneous group of malignancies, often managed with strategies adapted from colorectal...
Delays in cancer treatment initiation in Brazil: A nationwide analysis.
e13527 Background: Cancer continues to be a leading cause of mortality worldwide, but advancements in screening, early diagnosis, and treatment have impro...
Preliminary results from the dose-escalation stage of a phase I trial of an anti-CCR8 antibody in patients with relapsed/refractory cutaneous T-cell lymphoma (R/R CTCL).
2514 Background: Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCL). CCR8 is expressed in the skin resi...
Safety and efficacy of darolutamide in combination with androgen-deprivation therapy for prostate cancer: A systematic review and meta-analysis of randomized controlled trials.
e17089 Background: Prostate cancer (PC) is often treated with androgen-deprivation therapy (ADT), but progression remains a challenge. Darolutamide, a nex...
Carica papaya leaf extract (CPLE) versus placebo to improve chemotherapy induced thrombocytopenia (CIT): Results of a phase III triple blinded, randomized placebo controlled trial (PACT study).
12008 Background: There is a lack of approved therapeutic options to ameliorate CIT in patients with solid tumors receiving chemotherapy. Carica papaya le...
Phase IV pharmacovigilance study of biosimilar drugs in cancer: A Colombian cohort.
e23348 Background: Biosimilar drugs are essential for improving access to treatments in developing countries, reducing costs without compromising efficacy...
Association between epigenomic biomarkers and baseline clinical characteristics in patients with mCRPC treated with rucaparib in TRITON2.
5086 Background: TRITON2 is a phase 2 study evaluating rucaparib in 277 patients with metastatic castration resistant prostate cancer (mCRPC). PSA has bee...
A prospective, randomized controlled study to evaluate efficacy of argon beam coagulation versus conventional electrosurgical coagulation for cutting and coagulation during mastectomy with reconstruction.
e12586 Background: In patients undergoing mastectomy, the large raw surface from the dissection requires meticulous hemostasis to minimize surgical compli...
Electronic patient-reported outcomes with vital sign monitoring versus usual care during trastuzumab deruxtecan treatment for metastatic breast cancer: Updated results from the PRO-DUCE study.
1545 Background: The PRO-DUCE study (jRCTs031200387), a multicenter, randomized controlled study, evaluated the impact of ePRO plus body temperature (BT)/...
Patient characteristics and outcomes of T-cell prolymphocytic leukemia: A population-based analysis from the NCDB.
e18608 Background: T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive T-cell leukemia with poor prognosis and limited treatment options. It is r...
Multi-omics investigation for the tumor immune microenvironment and spatial heterogeneity in hepatocellular carcinoma with PVTT: MyCAFs and NID1 in immune evasion.
e16171 Background: Hepatocellular carcinoma (HCC), accounting for 70%-90% of primary liver cancers, often involves portal vein tumor thrombus (PVTT), a si...
Comprehensive profiling of immune and stromal alterations in colorectal cancer with diabetes mellitus through single-cell transcriptomics and proteomics.
e15635 Background: Colorectal cancer (CRC) and diabetes mellitus have become significant global health challenges, reaching epidemic levels. Evidence incr...
Non-muscle invasive bladder cancer burden: The impact of BCG shortage and its interaction with epidemiological patient profile—A population cohort study in Brazil.
e16602 Background: To evaluate the impact of the Bacillus Calmette-Guérin (BCG) shortage on treatment patterns and recurrence rates in non-muscle invasive...
Randomized, multi-center study of carfilzomib, lenalidomide, and dexamethasone (KRd) with or without daratumumab (D) in patients with newly diagnosed multiple myeloma (NDMM): The ADVANCE clinical trial.
7503 Background: The use of modern combination therapy in NDMM patients delivers deep and durable treatment responses inde...
Efficacy and safety of stereotactic body radiotherapy for cervical cancer (SCORE): Systematic review and meta-analysis.
e17537 Background: Locally advanced cervical cancer (LACC) remains a critical global health issue, disproportionately impacting low- and middle-income cou...
Tumor-educated platelets as a source of potential biomarkers for colorectal cancer.
3064 Background: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Current diagnosti...
Enhancing hematology & oncology (H/O) knowledge for internal medicine residents: A Dell Med guide.
e21010 Background: Internal medicine residency is a time of immense educational growth, especially relating to H/O. At Dell Medical School at The Universi...
A retrospective cohort study of real-world clinical outcomes in patients with CLL/SLL previously treated with covalent BTK inhibitor (cBTKi) and BCL2 inhibitor (BCL2i) regimens.
e19025 Background: Recent studies suggest that patients with CLL/SLL (herein, CLL) relapsed/refractory (R/R) to both cBTKi and BCL2i (double R/R [DR]) may...