Journal of Clinical Oncology
Articles in this Issue
Efficacy of TACE in combination with sorafenib versus sorafenib or TACE alone for advanced hepatocellular carcinoma: A meta-analysis of randomized controlled trials (RCTs).
e16259 Background: Hepatocellular Carcinoma (HCC) is the sixth fastest-growing type of cancer globally and the fourth largest cause of death related to ca...
Real-world treatment patterns and time-to-treatment discontinuation among advanced ALK-positive non-small cell lung cancer patients.
8603 Background: Advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) is typically treated with ALK tyrosine kinase inhib...
Hematologic response in patients with myelofibrosis treated with pacritinib in real-word clinical settings.
e23274 Background: Anemia is a major clinical burden for patients (pts) with myelofibrosis (MF) with a need for transfusions affecting quality of life and...
Telemedicine-enabled synchronous medical oncology and home hospice visits.
12100 Background: Hospice is underutilized at end-of-life by patients with cancer. Among the barriers to earlier acceptance of hospice may be the perceive...
AI-driven prediction of post-transplant survival and stratification of HCC recurrence risk.
4114 Background: Traditional selection criteria (e.g., Milan, UCSF) and scoring systems (MELD/PELD) for liver transplant eligibility in hepatocellular car...
Phase 2 expansions of OR502, an antibody targeting leukocyte immunoglobulin-like receptor B2 (LILRB2) ± cemiplimab in patients with advanced solid tumors.
TPS2669 Background: LILRB2 is an inhibitory receptor expressed on myeloid cells, including tumor-associated macrophages, which binds to HLA-class I protei...
Management of loop electrosurgical excision procedure with positive margins.
5534 Background: Loop Electrosurgical Excision Procedure (LEEP) is a primary management for preinvasive cervical disease. While often successful, around 1...
Proposed changes to the pathologic staging for colon cancer (CC): AJCC Colon Cancer Expert Panel (AJCCCCEP).
3520 Background: Recent analyses highlight nonhierarchical outcomes using the 8 th Edition AJCC staging system for CC. For instanc...
Acute bowel symptoms following relugolix and stereotactic body radiotherapy for localized prostate cancer.
e17086 Background: Androgen deprivation therapy improves cancer control in combination with prostate radiotherapy. Relugolix, an oral GnRH receptor antago...
Prevalence of and factors associated with financial toxicity among gastrointestinal cancer patients in Pakistan.
1616 Background: Financial toxicity (FT) impacts cancer care in low- and middle-income countries (LMICs), affecting treatment adherence and quality of lif...
The impact of targeted therapies on overall survival in advanced malignancy.
e15171 Background: Next-generation sequencing (NGS) analyzes DNA and RNA of malignant tumors through tissue or blood. NGS testing provides data about diag...
Post-hoc analysis evaluating selinexor maintenance therapy in patients with <i>TP53</i> wt endometrial cancer: Progression-free survival by clinical factors in the ENGOT-EN5/GOG-3055/SIENDO study.
5608 Background: At primary analysis of the phase 3 study of selinexor (SEL) maintenance treatment in patients (pts) with advanced/recurrent endometrial c...
Impact of SGLT2 inhibitors in patients with multiple myeloma and diabetes mellitus.
e19515 Background: The prevalence of diabetes mellitus (DM) is significantly higher in patients with multiple myeloma (MM) compared to the general populat...
Pregnancy and miscarriage before epithelial ovarian cancer (EOC) diagnosis in patients carrying germline <i>BRCA1/BRCA2</i> pathogenic variants.
e22516 Background: Several case-control studies have been performed to understand the prognostic impact of pregnancy after breast cancer in patients carry...
Efficacy and safety of trastuzumab deruxtecan in HER-2 expressing solid tumors: A systematic review and meta-analysis.
e15021 Background: HER2 expressing solid tumors represent a diverse group of malignancies with expression of protein HER2, including mostly breast but als...
Induction pembrolizumab plus cisplatin and 5-FU chemotherapy followed by chemoradiotherapy in locally advanced squamous cell cancer of oropharynx, hypopharynx or larynx: Results of multicenter prospective phase II study.
6070 Background: Chemoradiation with cisplatin or induction chemotherapy with docetaxel, platinum agent and 5-FU are associated with high toxicity. We hyp...
Sigvotatug vedotin (SV), an investigational integrin beta-6 (IB6)–directed antibody‒drug conjugate (ADC), and pembrolizumab combination therapy: Initial results from an ongoing phase 1 study (SGNB6A-001).
3010 Background: IB6, a tumor-associated membrane protein, is overexpressed in many solid tumors, including non-small cell lung cancer (NSCLC) and head an...
Role of the combination of 3 T whole-body MRI and 18F-FDG PET/CT in the management of multiple myeloma and smoldering myeloma: The new era of imaging.
7560 Background: FDG-PET/TC and MRI are both imaging diagnostic tools adopted in diagnosis and/or response assessment in multiple myeloma (MM) which can b...
Safety, efficacy, and tumor immune microenvironment changes with neoadjuvant chemotherapy and cemiplimab with or without alirocumab in stage 1B-3A non-small cell lung cancer.
TPS8118 Background: The addition of immune checkpoint blockade to neoadjuvant and adjuvant therapy is now standard of care in early-stage surgically resec...
Alcohol abuse among adults with esophageal cancer and impact on outcomes of esophagectomy.
e16056 Background: Recent reports from the American Cancer Society confirmed a rising incidence, mortality rate, and burden of esophageal cancer in the Un...
Relative lymphocyte percentage as a predictive biomarker for immune checkpoint inhibitor in metastatic melanoma: A real-world analysis.
e21549 Background: Response variability to immune checkpoint inhibitors (ICIs) necessitates the identification of predictive biomarkers. Relative lymphocy...
Impact of <i>TP53</i> somatic mutations on prognosis in endometrial cancer: A systematic review and meta-analysis.
e17618 Background: Endometrial cancer (EC) is the sixth most common cancer affecting women globally and is projected to become the fourth leading cause of...
Outcomes of veterans diagnosed with chronic myeloid leukemia in the tyrosine kinase inhibitor era.
e18567 Background: Since the development and approval of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL, the treatment landscape for chronic myeloid...
Preclinical and early stage clinical study on the regulation of tumor-associated inflammatory factor IL-6 by traditional Chinese medicine compound formula BDL.
e15131 Background: IL-6 has been found to be highly expressed in a wide range of cancer species and is thought to be associated with poor prognosis and tr...
A prospective, randomized control trial of concurrent paclitaxel and carboplatin along with radiotherapy versus concurrent cisplatin along with radiotherapy in carcinoma cervix patients at a tertiary care hospital of central India.
TPS5620 Background: In India, cervical cancer accounted for 9.0% of all cancers and 18.3% (127,526) of new cases in 2022 as per GLOBOCAN. It is leading ca...