Journal of Clinical Oncology
Articles in this Issue
Preclinical evaluation of <sup>64</sup> Cu-labeled cetuximab in immuno-PET for detecting sentinel lymph node metastasis in epidermal growth factor receptor–positive breast cancer.
e15061 Background: Despite advances in breast cancer imaging, reliable detection of sentinel lymph node (SLN) metastasis remains challenging. This study a...
Utilizing the EORTC Item Library to develop a tailored patient-reported outcome measure (PROM; CSCC-NAAP-32) to evaluate quality of life in resectable advanced (RA) cutaneous squamous cell carcinoma (CSCC).
e18014 Background: RA CSCC most frequently involves the head and neck region, with close proximity to important functional structures. Standard-of-care tr...
Bispecific antibody therapy in central nervous system (CNS) multiple myeloma (MM): Multicenter retrospective study.
e19505 Background: CNS involvement in MM is a rare, aggressive extramedullary manifestation with a poor prognosis (~4 months). The blood-brain barrier lim...
Unraveling the complex code of tumor microenvironment and heterogeneity by comparing multiple primary lung adenocarcinomas and intrapulmonary metastasis: A multidimensional exploration.
e20542 Background: Current diagnostic criteria for multifocal lung adenocarcinoma rely primarily on histopathology and next-generation sequencing. However...
Neoadjuvant mFOLFOXIRI chemotherapy with or without cadonilimab versus mFOLFOX6 alone in locally advanced colorectal cancer: A randomized phase II study (OPTICAL2).
3599 Background: The current standard treatment for locally advanced rectal cancer is chemoradiotherapy (CRT) followed by total mesorectal excision (TME)...
Outcomes of neoadjuvant endocrine therapy (NAET) versus neoadjuvant chemotherapy (NAC) in stage II-III invasive lobular carcinoma (ILC).
603 Background: ILC is a distinct subtype of breast cancer, accounting for up to 15% of cases, and is characterized by unique clinical and pathological fe...
Effect of a systemically administered innate immune modulator on anti-tumor activity against metastatic osteosarcoma.
e23504 Background: Osteosarcoma (OSa) is the most common malignant bone tumor with limited treatment options and poor outcomes in advanced metastatic case...
An observational study to evaluate pattern of usage of immune checkpoint inhibitors in the 1st line treatment of various advanced solid tumors, their efficacy and their toxicity profile.
e14617 Background: With the increasing evidences of immunotherapy, use of immune checkpoint inhibitors have been increased in various advanced malignancie...
Patient Priorities Care for older breast cancer survivors: A patient-centered approach to improve quality of breast cancer survivorship.
TPS1662 Background: Older adult breast cancer survivors have higher rates of chronic conditions compared with other cancer survivors and may have a higher...
PD-1–directed intratumoral immunotherapy for cutaneous carcinomas: Interim results from an ongoing study of INTASYL PH-762.
9591 Background: Immune checkpoint-targeted antibodies directed at PD-1 or PD-L1 block co-inhibitory receptors expressed by anti-tumor T cells, breaking i...
Understanding the clinical and molecular phenotype of cancer of unknown primary (CUP) with a lung cancer profile.
e20567 Background: Advances in cancer diagnostics including genomic testing has improved our ability to determine the likely tissue of origin (TOO) in CUP...
Master protocols in oncology: Opportunities, challenges, and strategic approaches to design and implementation.
e23010 Background: Master protocols, encompassing basket, umbrella, and platform trials, have emerged as innovative frameworks for oncology research. By e...
Obesity as a predictor of in-hospital outcomes in solid tumours with cardiovascular comorbidities.
e24006 Background: Obesity is a risk factor for both cancer and cardiovascular (CVS) disease. Although its impact on the development of CVS conditions and...
Leveraging natural language processing to understand financial toxicity in cancer care: A thematic and sentiment analysis of online patient narratives.
e13602 Background: Financial toxicity associated with cancer treatment significantly impacts patient outcomes and quality of life. Traditional research me...
In-hospital outcomes of patients admitted with chronic obstructive pulmonary disease exacerbation (COPDE) and comorbid lung cancer: An analysis of the National Inpatient Sample (NIS).
e20032 Background: Chronic Obstructive Pulmonary Disease (COPD) is a prevalent condition among smokers, often leading to substantial morbidity. Lung cance...
Analysis of serous carcinoma subgroup in FRUSICA-1: Fruquintinib plus sintilimab in treated advanced endometrial cancer (EMC) patients (pts) with pMMR status.
5596 Background: Serous carcinoma represents approximately 10% of all EMC, has the highest recurrence rate and is responsible for a disproportionate 40% o...
Phase 1 clinical update of IMA203, an autologous TCR-T targeting PRAME in patients with PD1 refractory metastatic melanoma.
2508 Background: Frequent recurrence and limited long-term survival in unresected or metastatic melanoma after relapse from 1L checkpoint inhibitor treatm...
Research on cancer-related cognitive impairment: A National Institutes of Health (NIH) grant portfolio analysis (2017–2024).
e24039 Background: Cancer-related cognitive impairment (CRCI) among cancer survivors impacts school, work, and psychosocial functioning. With increasing s...
Disparities in colorectal cancer incidence and mortality in Appalachian Kentucky.
e15673 Background: Since the late 1990s, both the incidence and mortality of invasive colorectal cancer (CRC) have decreased across the United States, inc...
<i>PCDHGB7</i> : A universal cancer-only marker (UCOM) and novel diagnostic tool for diverse tumors.
e15068 Background: The heterogeneity of tumors promoting the development of precision medicine，however, tumors also share certain common Hallmarks, sugge...
Evaluating pegylated SN38 (PLX38A) and rucaparib in <i>TP53</i> wild-type endometrial cancer.
e15125 Background: Endometrial cancer (EC) is the most common gynecologic malignancy, with endometrioid being the most prevalent histology. Approximately...
Early prediction of prognosis in advanced solid tumor patients using tumor growth rates with <i>g</i> score in early phase clinical trials.
3149 Background: The primary objective of early phase clinical trials is to evaluate the safety of investigational drugs, which requires participants to h...
The association between emotional distress prior to receiving immune checkpoint inhibitors and overall survival among patients with cancer: A population-based study.
12106 Background: Immune checkpoint inhibitors (ICIs) are widely used across cancer care. Emerging evidence from smaller studies links pretreatment emotio...
Paired DNA/RNA genetic testing to uncover cryptic pathogenic variants (PV) associated with PTEN hamartoma tumor syndrome (PHTS) and hereditary cancer (CA).
e22598 Background: Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PTHS) is a family of related genetic disorders including Cowden Syndrom...
The preliminary efficacy and safety results of neoadjuvant phase II study of anlotinib plus tislelizumab combined with chemotherapy in triple-negative breast cancer.
e12600 Background: The KEYNOTE-522 trial demonstrated that adding pembrolizumab to chemotherapy improves the pathologic complete response (pCR) rate and s...