Journal of Clinical Oncology
Articles in this Issue
Disease course of dMMR endometrial cancer in real-world clinical practice.
e17646 Background: Mismatch repair deficient (dMMR) endometrial cancer represents a distinct molecular subgroup with a different disease course. With the...
Genomic and proteomic predictors of sites of metastases in renal cell carcinoma.
4538 Background: Among patients with renal cell carcinoma (RCC), the most common sites of metastasis are lung, lymph nodes, and bone. While some sites of...
Gene set enrichment analysis of melanoma primary tumor transcriptome to identify pathways associated with lymph node metastasis.
e21572 Background: Lymph node metastasis (LNM) is a critical prognostic indicator in melanoma, guiding clinical decisions regarding staging, treatment, an...
From chemotherapy allergy to tolerance: Desensitization as a safe alternative in oncology.
11057 Background: Hypersensitivity reactions (HSRs) are a significant challenge in oncology, often leading to treatment modifications or interruptions. Ra...
Comparative effectiveness of mental health interventions on anxiety, depression and quality of life among cancer patients: A systematic review and network meta-analysis.
e23047 Background: Cancer patients frequently experience mental health (MH) concerns, which have a detrimental impact on their overall well-being. Numerou...
Impact of protein-energy malnutrition on inpatient mortality, healthcare cost and clinical outcomes among patients with head and neck cancer.
11064 Background: Protein-energy malnutrition (PEM) is a critical issue among patients diagnosed with head and neck cancers (HNC), primarily due to the tu...
Prognostic value of the estrogen receptor alpha, ESR1, and aromatase expression in non-small cell lung cancer: A meta-analysis.
e20529 Background: Despite the significant advancements in recent decades, lung cancer remains the leading cause of cancer-related mortality. A potential...
Preliminary effectiveness and acceptability of single-session acupuncture with infusion therapy at an academic cancer center.
e24048 Background: Acupuncture is an evidence-based integrative oncology treatment gaining popularity among cancer patients and providers for addressing c...
OMX-0407: A novel spectrum-selective small molecule kinase inhibitor in advanced/metastatic solid tumors.
3103 Background: OMX-0407 is an orally available spectrum-selective kinase inhibitor that targets key oncology-relevant tyrosine kinases and salt-inducibl...
Phase III study to evaluate the efficacy and safety of GLSI-100 (GP2 + GM-CSF) in breast cancer patients with residual disease or high-risk PCR after both neo-adjuvant and postoperative adjuvant anti-HER2 therapy: Flamingo-01.
TPS618 Background: GP2 is a biologic nine amino acid peptide of the HER2/ neu prot...
Toripalimab with chemoradiotherapy followed by toripalimab maintenance therapy for newly diagnosed, high-risk, locally advanced cervical cancer (TorCH-CC): A single-arm phase II study.
5520 Background: Despite concurrent chemoradiation (CRT) being the standard treatment, patients with high-risk locally advanced cervical cancer (FIGO 2018...
‘One button push’ fully automated PSMA PET quantification: Correlation with progression free and overall survival in patients undergoing [ <sup>177</sup> Lu] Lu PSMA therapy for metastatic castrate resistant prostate cancer.
5054 Background: [ 177 Lu]Lu-PSMA is an effective treatment in metastatic castrate-resistant prostate cancer (mCRPC). Whole body s...
The impact of HIV and age on sociodemographic characteristics, inpatient metrics, and complications in Burkitt's lymphoma hospitalizations: A nationwide analysis (2016–2021).
e19073 Background: Burkitt's lymphoma (BL) is an aggressive germinal center lymphoma with a worse prognosis in middle-aged and older adults. The sporadic...
Effect of the RKIP-SNAIL-YY1 axis on immune evasion in GBM.
e14033 Background: Glioblastoma multifome (GBM)is an aggressiveand malignant form of brain cancer, constituting approximately 12-15 % of all primary brain...
Efficacy and molecular predictors of radiotherapy combined with bevacizumab on desmoid tumor (aggressive fibromatosis).
e23535 Background: Desmoid tumors are rare, highly recurrent soft-tissue tumors with limited responses to non-surgical therapies. Radiotherapy combined wi...
Body composition and allostatic load in racially and ethnically diverse patients with metastatic colorectal cancer.
e15598 Background: Patients with metastatic colorectal cancer (mCRC) are living longer due to treatment advances; however, adverse phenotypes of body comp...
Accuracy of artificial intelligence models integrating machine learning and deep learning in detecting microvascular invasion in liver cancer: A systematic review and meta-analysis.
e16184 Background: Hepatocellular carcinoma (HCC) is a global health challenge, ranking sixth in incidence and third in cancer-related mortality. Microvas...
Trends in non-Hodgkin lymphoma and sepsis-related mortality among older adults, 1999–2020: A CDC WONDER database analysis.
e19067 Background: Non-Hodgkin lymphoma (NHL) is the sixth most common malignancy and the most prevalent type of lymphoma. Patients with NHL are at an ele...
Identification and validation of arsenic-associated genes and risk model for predicting lung cancer.
e13631 Background: Lung cancer, the leading cause of cancer-related mortality globally, constitutes approximately 12.4% of all cancer diagnoses. Environme...
Mammography results in male <i>BRCA</i> carriers.
10618 Background: Patients assigned male at birth (AMAB) with pathogenic germline variants (PGVs) in BRCA1 or BRCA2...
Phase Ib study of a plasmid DNA–based immunotherapy encoding the hTERT, PSMA, and WT1 (INO-5401) +/- IL12 (INO-9012) followed by electroporation in cancer patients and healthy individuals with <i>BRCA1/2</i> mutations.
10505 Background: Pathogenic variants in BRCA1/2 increase the risk of breast, ovarian, pancreatic and prostate cancer. Non-surgica...
A phase 1b, open-label, safety, tolerability, and efficacy study of HC-7366 in combination with belzutifan in patients with advanced or metastatic renal cell carcinoma (NCT06234605).
TPS4614 Background: HC-7366 is a novel, highly selective and potent activator of general control nonderepressible 2 (GCN2) kinase, a core regulator of met...
Use of early EBV DNA clearance to select optimal induction chemotherapy cycles for locoregional advanced nasopharyngeal carcinoma.
6076 Background: Based on 3 cycles of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregion...
Exploratory analysis from NEOAVAX, a neoadjuvant trial of avelumab/axitinib in patients (pts) with localized renal cell carcinoma (RCC) who are at high risk of relapse after nephrectomy.
4509 Background: NEOAVAX (NCT03341845) is an open label, single arm, phase II trial, investigating 12 weeks of neoadjuvant avelumab/axitinib prior to neph...
Trends in female breast cancer among adolescent and young adults in Southeast Asia.
1597 Background: Breast cancer is the leading cancer among women globally and poses a growing public health challenge, particularly in adolescents and you...