Journal of Clinical Oncology
Articles in this Issue
Updated overall survival analysis and examination of subsequent therapy in endometrial cancer (EC) patients (pts) treated with pembrolizumab plus carboplatin/paclitaxel (CP) as compared to CP plus placebo (PBO) in the NRG-GY018 trial.
5502 Background: NRG-GY018, the only phase 3 trial examining dMMR and pMMR EC populations independently, identified a 70%...
Phase 1 study of META 10-19, an IL-10-expressing, anti-CD19 CAR T cell product in patients with high-risk DLBCL.
2552 Background: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of B cell lymphoma. Howev...
A phase II trial of olaparib in combination with pembrolizumab in metastatic uveal melanoma.
9553 Background: Metastatic uveal melanoma (mUM) has a poor prognosis with modest response to immune checkpoint blockade (...
Dominant chromosomal abnormalities in breast cancer metastasis to CNS as compared with systemic metastasis demonstrated by liquid biopsy.
1035 Background: Breast cancer (BrC) central nervous system (CNS) metastases are believed to be biologically and therapeut...
RET fusion–positive lung adenocarcinoma: Partner-specific clinicopathological characteristics, co-mutation profiles, and implications for targeted and immunotherapy.
8615 Background: RET fusions represent actionable oncogeni...
Five-year outcomes of osimertinib-based treatment in a phase III study comparing EGFR tyrosine kinase inhibitor (EGFR-TKI) monotherapy and EGFR-TKI with inserted cisplatin plus pemetrexed as a first-line treatment for advanced non-squamous non–small-cell lung cancer harboring <i>EGFR</i> mutation (JCOG1404/WJOG8214L).
8649 Background: JCOG1404/WJOG8214L was an open label, multicenter, randomized phase III study comparing EGFR-TKI monother...
In-hospital complications and outcomes of autologous stem cell transplantation in diffuse large B-cell lymphoma with and without chronic kidney disease.
e19109 Background: Chronic kidney disease (CKD) may increase transplant-related toxicity during autologous stem cell trans...
Thyroid cancer risk in systemic lupus erythematosus: A population-based retrospective cohort study.
e18043 Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease marked by immune dysregulation and l...
Trends, outcomes, and disparities in lung cancer–related hospitalizations in the United States: 2012–2022.
e20112 Background: Lung Cancer remains a leading cause of morbidity and mortality in the United States and accounts for si...
Bridging gaps in relapsed/refractory follicular lymphoma care: Perceived barriers to treatment and clinical trial access.
e13547 Background: Despite expanding therapeutic options and clinical guidelines for relapsed/refractory follicular lympho...
Bladder preservation in patients with urothelial muscle-invasive bladder cancer who refused radical cystectomy after clinical complete response to trans-urethral resection of bladder tumors and neoadjuvant systemic chemotherapy. A retrospective single-center experience.
e16585 Background: Neoadjuvant systemic chemotherapy (NASCT) followed by radical cystectomy (RC) is widely used among the...
Evaluation of circulating tumor DNA (ctDNA) following liver resection in a high-risk population with colorectal liver metastases.
3556 Background: Liver resection is routinely performed for oligometastatic colorectal cancer (CRC). ctDNA analysis is bec...
Risk factors in association with adrenal insufficiency in hospitalized solid tumor patients on immunotherapy.
e24183 Background: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy and significantly improved clinical...
Burden of early-onset cancers in Hungary: Nationwide trends in incidence and mortality.
e22616 Background: Cancers diagnosed before 50 years of age (“early-onset” cancers) are increasingly recognized as a disti...
Real-world outcomes of mogamulizumab retreatment in cutaneous T-cell lymphoma: A single-center retrospective study.
7096 Background: Mogamulizumab, monoclonal antibody against CCR4, is approved for relapsed/refractory cutaneous T cell lym...
Feasibility study of prolonged administration of naxitamab, irinotecan, and temozolomide for patients with relapsed or refractory neuroblastoma.
TPS10058 Background: Neuroblastoma is a malignant childhood tumor of the sympathetic nervous system. Cure rates are unsati...
Shifting patterns in PMBCL and DLBCL care: The role of community oncology centers in the U.S.
e19071 Background: Historically, clinical trials and adoption of novel therapies for oncology have been concentrated withi...
Facility-level differences and outcomes in elderly primary CNS lymphoma in the NCDB.
e13762 Background: PCNSL is a rare, aggressive subtype of non-Hodgkin lymphoma with increasing incidence in the U.S (ACSPM...
Assessing current sleep–cognition evidence and translation into oncology practice.
e24129 Background: Despite strong evidence linking sleep disturbance with cognitive outcomes in cancer survivors, oncology...
Prevalence of oral and genital HPV-45 and non–vaccine-targeted HPV-35 among U.S. adults.
10597 Background: High-risk human papillomavirus (HPV) types 35 and 45 are oncogenic non-16/18 subtypes that contribute me...
Global sex-based disparities in pancreatic cancer clinical trial enrollment: A systematic review and meta-analysis.
1654 Background: Sex-based disparities in oncology trial enrollment are well recognized, yet their magnitude and consisten...
Adverse events and their management in patients with tenosynovial giant cell tumor (TGCT) treated with pimicotinib, after longer-term follow-up from the global phase 3 MANEUVER trial.
11571 Background: TGCT is a rare, locally aggressive, soft-tissue tumor associated with significant morbidity. Pimicotinib...
Real-world pregnancy outcomes following temporary interruption of adjuvant endocrine therapy in early-stage hormone receptor–positive breast cancer.
e12702 Background: The POSITIVE trial established the feasibility of temporary interruption of adjuvant endocrine therapy...
The impact of potentially inappropriate medications on performance status, functional status, and overall survival in older adults with prostate cancer.
e17018 Background: The 2023 American Geriatric Society's Beers Criteria lists around 100 medications with potential side e...
Integrated genomic and transcriptomic profiling of a breast cancer cohort in the UAE compared with TCGA.
e13015 Background: Breast cancer (BC) in the United Arab Emirates (UAE) remains under-characterized relative to large refe...