Journal of Clinical Oncology
Articles in this Issue
Immunotherapy for advanced gastric cancer: Experience from Uzbekistan.
e23352 Background: Gastric cancer is a major cause of cancer-related mortality worldwide and remains highly prevalent in C...
Efficacy and safety of adjuvant immune checkpoint inhibitors in resected renal cell carcinoma: Systematic review and meta-analysis of phase III trials.
e16514 Background: Phase III trials of adjuvant immune checkpoint inhibitors (ICIs) in resected renal cell carcinoma (RCC)...
Spectrum of autosomal recessive pediatric cancer predisposition syndromes in a population with high consanguinity.
e22637 Background: Most studies of pediatric cancer predisposition syndromes (CPS) are derived from Western populations, r...
Association of estrogen receptor status with survival outcomes in neuroendocrine carcinoma of the breast: A SEER Research Plus analysis (2010–2021).
e12759 Background: Neuroendocrine carcinoma of the breast (NECB) is a rare histologic sub-type with heterogeneous clinical...
Early inpatient chemotherapy in central nervous system (CNS) tumors: Predictors, treatment patterns, and in-hospital outcomes.
e14035 Background: Timely inpatient chemotherapy may alter the trajectory of acute CNS tumor hospitalizations by controlli...
RADIANCE predictive score: A new model of radiological markers for prediction of antiangiogenics efficacy in pretreated metastatic colorectal carcinoma (mCRC)—RADIANCE trial.
e15553 Background: Antiangiogenic agents are widely used in mCRC. The ABACO trial recently showed that high angiogenesis g...
Surrogate end points for overall survival: A meta-analysis exploring adequacy of progression-free survival and objective response in randomized NSCLC trials.
e20702 Background: Surrogate endpoints such as progression-free survival (PFS) and objective response rate (ORR) are widel...
Incorporating CA19-9 testing in a prospective study of pancreatic cancer surveillance (PCS) among high-risk individuals (HRIs).
10527 Background: For individuals at an increased risk of pancreatic cancer (PC), imaging-based PCS is recommended. Howeve...
Epidemiological trends and burden of liver cancer mortality due to hepatitis B in Sub-Saharan Africa: A retrospective analysis from 1990 to 2023 with advanced machine learning forecasting to 2050.
e16233 Background: Liver cancer due to hepatitis B virus (HBV) remains a major cause of cancer mortality in sub-Saharan Af...
Comprehensive genomic profiling of matched ctDNA and tissue from patients with four common cancers enrolled to the NCI-MATCH trial.
3045 Background: In the NCI-MATCH trial (NCT02465060), tumor tissue from 5,954 patients with advanced cancers underwent ne...
First-line fovinaciclib versus placebo combined with aromatase inhibitor for advanced breast cancer: A randomized, double-blind phase 3 study.
1090 Background: Endocrine therapy combined with a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor is the standard fir...
Antitumor activity of amivantamab by consensus molecular subtypes in <i>RAS</i> / <i>BRAF</i> wild-type metastatic colorectal cancer: Secondary analyses from the phase 1b/2 OrigAMI-1 study.
3548 Background: Colorectal tumors are classified by mutational subtypes and sidedness, which inform treatment and outcome...
Temporal patterns of irAE onset by treatment regimen and organ system in a pan-cancer ICI-treated cohort.
e23398 Background: Immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICIs) can manifest at heteroge...
The association between social capital and cancer screening rates in the United States.
e22550 Background: Cancer screening remains a cornerstone of cancer prevention, yet substantial geographic variation persi...
Minimally invasive vs open pancreaticoduodenectomy for periampullary tumors: A systematic review and updated meta-analysis.
e16474 Background: Laparoscopic pancreaticoduodenectomy (LPD) is increasingly being performed for periampullary tumors. Ho...
A phase I study to assess the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of KH617 for patients with advanced solid tumors (including diffuse gliomas of adulthood).
2046 Background: Outcomes in patients (pts) with recurrent glioblastoma (rGBM) are poor, with historical median overall su...
Clinical features and outcomes of EBER-negative nasopharyngeal carcinoma: A large cohort study across China.
e18144 Background: The current TNM staging system and treatment guidelines are primarily based on EBER-positive nasopharyn...
ALFA score as a predictor of long-term benefit with frontline brigatinib in <i>ALK</i> + advanced NSCLC: A ctDNA-based composite biomarker from ALTA-1L.
8646 Background: Optimal sequencing of ALK-TKI in 1st-line ALK+ NSCLC remains cont...
Open, laparoscopic, versus robotic surgery for Siewert type II/III adenocarcinoma of esophagogastric junction: A systematic review and Bayesian network meta-analysis.
e16093 Background: The optimal surgical approach for Siewert type II/III adenocarcinoma of the esophagogastric junction (A...
GZMK+ T cells in glioblastoma and an activated, non-exhausted phenotype.
e14071 Background: Glioblastoma (GBM) bears a survival estimate below 10% at 5 years, despite surgery and standard chemora...
Pre-transplant MRD negativity and TP53 mutation status determine survival after CAR-T therapy bridged to allo-HSCT for refractory/relapse B-ALL.
6556 Background: The feasibility and outcomes of bridging relapsed/refractory (R/R) B-lineage acute lymphoblastic leukemia...
Patient experience and quality of life in a decentralized cancer care model for advanced prostate cancer.
e13611 Background: Decentralized cancer care models may reduce treatment burden for patients with advanced prostate cancer...
A phase 2 study of ipatasertib in combination with pembrolizumab for first-line treatment of recurrent or metastatic squamous cell cancer of the head and neck.
6006 Background: Single agent pembrolizumab in relapsed/metastatic head and neck squamous cell carcinoma (R/M HNSCC) has l...
A clinicopathological and molecular profiling study of <i>EGFR</i> mutations in a cohort of 215 lung cancer patients from Eastern India.
e20708 Background: Epidermal Growth Factor Receptor (EGFR) mutations are a critical biomarker in non-small cell lung cance...
CXCR4/CXCL12 antagonism to disrupt microenvironment-mediated resistance for autologous transplant conditioning in multiple myeloma: A systematic review and mechanistic synthesis.
e19523 Background: Despite advances in therapy, multiple myeloma remains incurable, with relapse driven by residual diseas...