Journal of Clinical Oncology
Articles in this Issue
Antiviral prophylaxis to prevent hepatitis B reactivation in patients receiving anti–CD20-based chemotherapy and with inactive HBV infection: Systematic review and meta-analysis of randomized controlled trials.
e15034 Background: Patients with history of inactive hepatitis B receiving anti-CD20-based chemotherapy for lymphoma remai...
Interim analysis of CaboMain: A prospective, single-arm phase 2 clinical trial of cabozantinib as maintenance therapy for patients with “ultra-high-risk” pediatric solid tumors.
10014 Background: There are patients with pediatric solid tumors, including those with relapsed/refractory disease, with “...
Risk of multiple primary malignancies in mantle cell lymphoma: Insights from a SEER-based study (2000–2021).
e19051 Background: With increasing tumor survival rates and advancements in diagnostics, the incidence of multiple primary...
Treatment with brentuximab vedotin in vitro and CAR T-cell function and viability: Implications for combination or sequential therapeutic approaches for lymphoma.
e15014 Background: Brentuximab vedotin (BV), an antibody-drug conjugate targeting CD30, demonstrates potent cytotoxicity a...
Identifying patients at risk for non-receipt of guideline-concordant treatment in pancreatic cancer using electronic health record data and machine learning.
1576 Background: Non-receipt of guideline-concordant treatment (GCT) for pancreatic cancer is associated with worse outcom...
Protective factors supporting caregiver well-being in glioblastoma.
12095 Background: Caregiving in glioblastoma (GBM) means dealing with cancer symptoms, plus the neurological decline that...
A US real-world study of second-line outcomes in advanced ovarian cancer by first-line PARP inhibitor maintenance exposure.
e17564 Background: As PARPi maintenance (MTx) is widely used after first-line (1L) platinum-based therapy for advanced ova...
Metric indicators of lymphedema and their impact on symptoms and quality of life in breast cancer patients: A longitudinal real-world study.
e12713 Background: Upper-limb lymphedema is a frequent complication of breast cancer, with impact on symptoms and quality...
Intrathecal iPSC-derived natural killer cells combined with the Stupp regimen for newly diagnosed WHO grade 4 glioma: A phase I trial.
2072 Background: WHO grade 4 glioma has a poor prognosis despite standard Stupp therapy. Induced pluripotent stem cell–der...
AI-assisted prediction of radiation failure patterns and survival after stereotactic radiosurgery for brain metastases: A multicenter study.
2023 Background: Brain metastases occur in approximately 20%–40% of patients with cancer and are associated with substanti...
Adolescent and young adult cancer death burden in the United States from 1990 to 2023.
e22599 Background: Reports of increasing adolescent and young adult (AYA) cancer burden in the United States (US) may be i...
Safety and efficacy of perioperative use of tislelizumab in treating clinically node-positive urothelial carcinoma: A prospective clinical study.
e16615 Background: Recent studies suggest that the preservation of tumor-draining lymph nodes (TDLN) may enhance the sensi...
Cholangiocarcinoma care across America: A tale of two coasts.
e16241 Background: Cholangiocarcinoma (CCA) is an aggressive biliary cancer with a historically poor prognosis and a recen...
Multicenter clinical study of [ <sup>18</sup> F]AlF-HER2-BCH PET/CT as a molecular pathology tool for linear quantification of HER2 expression levels in breast cancer.
3071 Background: Determining the human epidermal growth factor receptor 2 (HER2) status is essential in metastatic breast...
Assessment of CAR-T clinical trial availability and accessibility in the United States.
1558 Background: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed outcomes in hematologic malignancies and...
Global lung cancer burden attributable to environmental and occupational exposures.
e22677 Background: Lung cancer without tobacco exposure is a growing and preventable source of global morbidity driven by...
Gut microbiome characteristics in patients with hormone receptor–positive (HR+) HER2− breast cancer treated with adjuvant abemaciclib: Biomarker analysis of the TRADE trial.
563 Background: Adjuvant abemaciclib reduces recurrence risk and improves overall survival in patients with high-risk node...
Improving multidisciplinary care in the treatment of muscle-invasive bladder cancer: A quality improvement initiative.
e23315 Background: The rapidly evolving treatment landscape for bladder cancer has introduced several new therapy classes,...
CheckMate-901: Association of tumor and peripheral biomarker profiles with durable disease control in metastatic urothelial carcinoma treated with nivolumab plus ipilimumab.
4525 Background: Patients (pts) with untreated, unresectable, or metastatic urothelial carcinoma (mUC) have limited therap...
A machine learning model for predicting recurrence and survival in stage I-III colorectal cancer.
e15518 Background: While 5-year overall survival for stage I-III colorectal cancer (CRC) is relatively high, the risk of r...
CAPTURE: A phase II trial evaluating alpelisib + fulvestrant vs capecitabine in advanced breast cancer patients with <i>PIK3CA</i> -mutant circulating DNA following CDK4/6 inhibition.
1064 Background: PIK3CA mutations are a key therapeutic target in ER+ advanced breast cancer (ABC) rea...
Clinical impacts of the 2025 Southern California wildfires among childhood cancer patients and survivors: A pilot study.
e13515 Background: Climate change-related natural hazards threaten healthcare delivery, and wildfires are one such hazard....
Pulmonary metastasis in chondroblastoma: An institutional cohort and meta-analysis.
e23506 Background: Chondroblastoma is a benign bone tumor with rare potential for pulmonary metastasis. The true incidence...
Intracranial Rosai–Dorfman disease: Systematic review of published case reports and small series (2000–2025).
e14108 Background: Intracranial Rosai-Dorfman disease (RDD) is a rare histiocytic disorder that often mimics meningioma an...
HER2 expression heterogeneity (IHC/FISH) in breast cancer: A systematic review and meta-analysis of prognostic implications.
e13023 Background: Human epidermal growth factor receptor 2 (HER2/ERBB2) is a validated predictive and prognostic biomarke...