Journal of Clinical Oncology
Articles in this Issue
A phase 1/2 study of EP0062 (vosilasarm), a first-in-class oral selective androgen receptor modulator (SARM), in combination with standard-of-care endocrine therapy +/- targeted therapies in patients with advanced or metastatic AR+/ER+/HER2− breast cancer.
TPS1151 Background: EP0062 (vosilasarm), a first-in-class, oral, non-steroidal, Selective Androgen Receptor Modulator (SAR...
Age-related efficacy of antibody-drug conjugates in solid tumors: A meta-analysis.
1664 Background: Antibody–drug conjugates (ADC) have revolutionized cancer therapeutics, with various ADC improving clinic...
Dynamic circulating tumor DNA profiling for prediction of long-term clinical benefit in pMMR locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy plus sintilimab.
3590 Background: Immune checkpoint inhibitors (ICIs) targeting PD-1 have significantly improved outcomes in locally advanc...
Clinicopathologic features and survival outcomes of HER2-low versus HER2-negative (IHC 0) breast cancer in real-world practice.
e23417 Background: With the advent of antibody–drug conjugates, HER2-low disease emerged as a clinically relevant subgroup...
Examining the tumor microbiology and microenvironment of patients with triple-negative inflammatory breast cancer receiving KEYNOTE-522.
e12594 Background: Patients with Stage III triple negative (TN) inflammatory breast cancer (IBC) are treated based on stan...
Phase 2/3 trial of pumitamig (PD-L1 × VEGF-A bsAb) plus chemotherapy versus bevacizumab plus chemotherapy in previously untreated, unresectable, or metastatic colorectal cancer (ROSETTA CRC-203).
TPS3672 Background: Microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer (mCRC) demonstrated limi...
A phase I, first-in-human study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-tumor activities of GenSci139 in patients with solid tumors.
TPS4638 Background: HER2 and EGFR are frequently co-expressed in solid tumors. Bispecific targeting of these receptors can...
Construction and clinical application of a bundled nursing care program for PICC management in patients with nasopharyngeal carcinoma.
e13612 Background: Purpose To develop a bundled nursing care program for peripherally inserted central catheter (PICC) man...
Comparative effectiveness of adjuvant chemotherapy on survival in node-positive (N2/N3), stage III ER+/HER2− invasive lobular breast cancer (ILC) versus invasive ductal cancer (IDC).
545 Background: ILC is characterized by loss of E-cadherin expression, with distinct biological and clinical features, and...
Antigen presentation suppression as a hallmark of immune evasion and poor outcomes in small cell lung cancer.
8084 Background: Antigen-presenting machinery (APM) is critical for tumor immune recognition. The loss of APM promotes imm...
A phase 3 study of sacituzumab govitecan in patients with previously treated extensive-stage small cell lung cancer.
TPS8137 Background: Treatment options for extensive-stage small cell lung cancer (ES-SCLC) that has progressed after plati...
PTCy, abatacept, and short course of tacrolimus (CAST) therapy in GVHD prevention in mismatch-unrelated donors.
e18568 Background: Hematopoietic stem cell transplant (HSCT) remains a potentially curative therapy for a wide range of he...
Primary results from the triple-negative cohort of TBCRC-053 (P-RAD): A randomized trial of no, low, or high dose preoperative radiation with pembrolizumab and chemotherapy in node-positive breast cancer.
1011 Background: Approximately one-quarter of patients with node-positive, triple-negative breast cancer (TNBC) did not ex...
A randomized non-inferiority trial of an eHealth delivery alternative for cancer genetic testing for hereditary cancer (eREACH2).
10510 Background: Germline cancer genetic testing is a standard evidence-based practice, with established risk reduction a...
Bridging the gap between knowledge, attitudes, and practice regarding physical activity and exercise among Greek medical oncologists.
e23141 Background: Physical activity and exercise (PAE) are core components of evidence-based cancer care. However, eviden...
Ablation of oligo-residual disease to prolong progression-free survival in <i>EGFR</i> -mutant advanced NSCLC patients treated with third-generation EGFR-TKIs.
8633 Background: Combination of EGFR-TKIs with chemotherapy or amivantamab have become the standard of care for EGFR-mutan...
Node-sparing modified short-course radiotherapy combined with capecitabine and PD-1/CTLA-4 for MSS early, middle, and low rectal cancer (mRCAT-E): An open-label, single-arm, prospective multicenter clinical trial.
TPS3687 Background: The standard treatment for early-stage rectal cancer is radical resection. For patients' organ preserv...
Environmental exposure and prevalence of papillary thyroid cancer in West Virginia: An ecological analysis of per and polyfluoroalkyl substances (PFAS)–impacted regions.
6073 Background: Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread expo...
Real-world outcomes in patients (pts) with metastatic breast cancer (MBC) treated with trastuzumab deruxtecan (T-DXd) based on HER2 expression.
e13013 Background: T-DXd is an effective HER2-directed antibody-drug conjugate (ADC) approved for HER2-positive (IHC 3+ or...
Enhancing supportive care in malignant bowel obstruction: A QI project using virtual dietitian-led low-fiber diet education.
12068 Background: Malignant bowel obstruction (MBO) is a frequent, debilitating complication in patients with gynecologic...
Characteristics associated with five-star online reviews of oncologists.
e13533 Background: Patient satisfaction has become an increasingly important component of healthcare quality, leading to g...
Post-ARPI sequencing in mCRPC: A propensity-matched real-world comparison of <sup>177</sup> Lu-PSMA-617 versus docetaxel for early clinical outcomes.
5079 Background: Treatment sequencing in metastatic castration-resistant prostate cancer (mCRPC) after ADT and ARPI exposu...
Correlation of tumor-naive methylation-based preoperative ctDNA testing with pathologic upstaging and occult metastasis in early-stage solid tumors.
1616 Background: The TNM staging system serves as the cornerstone for most solid tumor treatment strategies. However, preo...
Mapping the association between federal AI investment and clinical validation in oncology: A multi-source ecosystem analysis.
e13663 Background: Artificial intelligence (AI) in oncology, including computer vision and radiomics, has expanded rapidly...
Cell proliferation, immune cell infiltration, and survival outcomes in sarcomas with high cancer-associated fibroblast expression.
11541 Background: Cancer-associated fibroblasts (CAFs) play an integral role in the tumor microenvironment and have been l...