Journal of Clinical Oncology
Articles in this Issue
Has early detection improved?: Trends in localized PDAC diagnoses in the U.S. (2004-2022).
e16454 Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers in the United States; most...
Pembrolizumab–lenvatinib beyond immunotherapy progression in endometrial cancer: A real-world analysis.
5612 Background: The integration of immune checkpoint inhibitors (ICIs) into frontline therapy for advanced or recurrent e...
Microbial dysbiosis as predictor of benefit from CBM588 as an adjunct to immune checkpoint blockade (ICB)–based first line therapies in metastatic renal cell carcinoma (mRCC).
4519 Background: The Clostridium butyricum -based live biotherapeutic, CBM588, dem...
Impact of endometrial cancer surgery on the development of cardiovascular risk factors in women under 51.
e17645 Background: In younger patients, the rising burden of endometrial cancer (EC) intersects with cardiovascular (CV) d...
Leisure-time physical activity among US cancer survivors, 2020-2024.
10623 Background: Physical activity (PA) after a cancer diagnosis reduces treatment-related side effects and improves qual...
Antibody-drug conjugate adoption in triple-negative breast cancer through community-based quality improvement.
e23328 Background: Community oncology settings face challenges adopting evidence-based protocols for integrating novel the...
Upfront low-dose diet-modified nilotinib versus standard imatinib in Indian patients with newly diagnosed chronic-phase chronic myeloid leukemia: The NILLOW phase II randomised trial.
6584 Background: Upfront use of second-generation tyrosine kinase inhibitors in chronic myeloid leukemia (CML) is limited...
Incidence of early-onset colorectal cancer in the United States: A population-based analysis (2000-2019).
e15676 Background: The incidence of colorectal cancer (CRC) among individuals younger than 50 years has been increasing in...
Interrupting sedentary time to improve cardiometabolic health and toxicity in patients with lymphoma receiving chemotherapy: The iSTAND trial.
TPS12173 Background: Among lymphoma patients treated with steroids, hyperglycemia is a common side effect. Episodes of hyp...
Real-World outcome of apalutamide therapy in mHSPC patients depending on age, dose reduction, and PSA decline: Data from the German AmPel trial.
e17094 Background: Data from the Titan Trial (apalutamide + ADT) showed a benefit for mHSPC patients who achieved low ( &l...
Early experience with T-cell receptor cellular therapy in advanced solid malignancies: A multi-center analysis of safety and efficacy.
e14511 Background: T-cell receptor (TCR) therapy, by targeting intracellular antigens, represents a significant expansion...
Trabectedin with concomitant radiotherapy in resectable retroperitoneal L-sarcoma: A multicenter, prospective, phase I/II trial—A collaborative study by the Spanish (GEIS), Italian (ISG), and French (FSG) groups.
11507 Background: Liposarcoma (LPS) and leiomyosarcoma (LMS) account for most retroperitoneal sarcomas. Despite complete r...
Multiplexed immunohistochemistry (mIHC) analysis and clinical outcomes of nelmastobart in combination with trifluridine/tipiracil and bevacizumab in patients with refractory colorectal cancer (phase 1b/2).
3602 Background: Colorectal cancer (CRC) patients who are refractory or intolerant to oxaliplatin- and irinotecan-based re...
Telehealth use at the end of life among Medicare decedents with cancers.
e23120 Background: Telehealth use has surged since the COVID-19 pandemic. For individuals with cancer approaching end-of-l...
Treatment strategies and survival outcomes in hepatic epithelioid hemangioendothelioma: A systematic review.
e16239 Background: The hepatic epithelioid hemangioendothelioma, or HEHE, is a very rare type of blood vessel cancer that...
A phase 1/2 study of REGN5668, a MUC16×CD28 costimulatory bispecific antibody, in combination with other targeted therapies, in patients with recurrent ovarian or endometrial cancer: Trial in progress update.
TPS5639 Background: REGN5668 and ubamatamab are immunoglobulin G4-based bispecific antibodies that bridge mucin 16 (MUC16)...
Machine learning–based multi-omics analysis to identify the role of MAN1C1 in pancreatic cancer and its clinical significance as a drug target.
e16475 Background: Exploring genes related to glycosylation modification, particularly the role of MAN1C1 in PDAC, contrib...
Workforce availability for cancer surgery in rural areas: A collaboration with the American Board of Surgery (ABS).
e13517 Background: Surgical care remains central to solid cancer treatment in adults. A shortage of surgeons, including in...
Twenty years of colon cancer epidemiology and treatment patterns in São Paulo, Brazil: A population-based analysis of observed vs. expected treatment utilization.
e13625 Background: Colon cancer disproportionately impacts survival in individuals living in low to middle-income countrie...
Financial and time toxicity among patients with cancer enrolled in pharmacotherapy clinical trials: Systematic reviews.
e24053 Background: Financial and time toxicity are increasingly described as burdens of cancer care, yet their magnitude a...
Understanding circulating tumor DNA (ctDNA) test uptake among diverse cancer patients: A real-world evidence study.
e23374 Background: Circulating tumor DNA (ctDNA) testing is increasingly used in oncology for clinical indications includi...
An audit of initial experience of stereotactic body radiotherapy for extracranial oligometastases.
e23333 Background: To retrospectively review the toxicity and early outcome data from patients who have received stereotac...
Inpatient CAR-T safety in the United States: Severe ICANS and CRS by donor source and antigen target (NIS 2022–2023).
e19006 Background: The field of CAR-T is rapidly expanding, with emerging allogeneic (donor-derived) platforms and multipl...
Population-level trends and geographic disparities in pancreatic cancer mortality among individuals with psychoactive substance use disorders: A retrospective analysis.
e22591 Background: Pancreatic cancer is a very lethal malignancy with persistently poor outcomes. Individuals with mental...
Primary breast malignancies in adolescents and young adults: The MD Anderson Cancer Center experience.
10006 Background: Primary malignancies of the breast rarely affect adolescents and are uncommon in young adults. Limited i...