Journal of Clinical Oncology
Articles in this Issue
Mechanistic evaluation of thymol in a rat model of methotrexate-induced intestinal injury: NF-κB, Nrf2/HO-1, PPARγ/SIRT1, and RIPK1/RIPK3/MLKL pathways.
e24172 Background: Thymol is a monoterpene phenol with numerous pharmacological properties, including antibacterial, antit...
Postoperative adjuvant therapy of donafenib in hepatocellular carcinoma with high-risk recurrence factors: A real world, prospective, observational study.
e16268 Background: The five-year recurrence rate of hepatocellular carcinoma (HCC) after hepatic resection is as high as 7...
Diagnostic yield after pre-biopsy steroid administration in primary CNS high-grade B-cell lymphoma.
7056 Background: Primary central nervous system high-grade B-cell lymphoma (PCNSL) is typically diagnosed via brain biopsy...
Interpretable machine learning to identify health system levers for survival outcomes of patients with prostate cancer.
1595 Background: Global disparities in prostate cancer outcomes are among the most pronounced across all cancer types. Whi...
Cross-stage validation of a multimodal machine learning model to predict pathological complete response to neoadjuvant chemotherapy or chemoimmunotherapy in resectable stage III non–small cell lung cancer.
8022 Background: Pathological complete response (pCR) after neoadjuvant chemoimmunotherapy is associated with improved out...
Predicting treatment effect on distant recurrence free survival from functional tumor volume change during neoadjuvant therapy: A Bayesian hierarchical model of I-SPY 2 MRI and survival data.
618 Background: In neoadjuvant cancer trials, early endpoints that predict treatment effect on survival identify promising...
Tremelimumab (T) + durvalumab (D) + chemotherapy (CT) vs pembrolizumab (P) + CT in 1L non-squamous (NSQ) metastatic NSCLC (mNSCLC) with <i>STK11</i> , <i>KEAP1</i> , and/or <i>KRAS</i> mutations (mut): Interim analysis (IA) of the phase 2b TRITON study.
8515 Background: Pts with STK11 , KEAP1 an...
IGNITE-Cerala: A phase II signal-seeking trial of ceralasertib targeting recurrent high-grade serous ovarian cancer with cyclin E1 overexpression with and without gene amplification.
5587 Background: Cyclin E1 ( CCNE1 ) gene amplification and protein over-expressio...
ETHAN: A phase II study comparing different endocrine therapies for male breast cancer.
TPS656 Background: Male breast cancer is a rare disease, and most cases are hormone receptor-positive (HR+). Due to a lack...
Bone health and antiresorptive agent use in Asian American Pacific Islander (AAPI) women with breast cancer.
e12696 Background: AAPI women with breast cancer (BC) may be at increased risk for poor bone health due to lower bone mine...
Unintended access barriers: How upper payment limit implementation may risk patient access.
e23053 Background: Four states currently operate prescription drug affordability boards (PDABs) with purported authority t...
A phase 2 multi-center pharmacodynamic study of the fatty acid synthase (FASN) inhibitor TVB-2640 in advanced <i>KRAS</i> -mutant non–small cell lung cancer.
3079 Background: Preclinical and translational studies demonstrate that KRAS-mutant NSCLC has a unique metabolic dependenc...
PTPRZ1–MET fusion and induction of reprogrammed immuno-microenvironment via MET–IFN-β–LGALS9 signaling pathway during IDH-mutant glioma progression.
e14088 Background: Recurrent IDH-mutant high-grade gliomas are difficult to treat, with limited effective targeted or immu...
National trends and disparities in cancer-related mortality among adults with diabetes in the U.S., 1999–2023.
e21003 Background: The prevalence of diabetes in the U.S. has nearly doubled, contributing to increased cancer risk due to...
Phase I study of the LiViT regimen (liposomal irinotecan, vincristine, and temozolomide) in pediatric patients with relapsed/refractory solid tumors.
10039 Background: Relapsed or refractory solid tumors in children and adolescents remain a major therapeutic challenge wit...
First-in-human PET imaging of <sup>68</sup> Ga-FC516, a novel ACP3-targeted radiotracer for prostate cancer.
5128 Background: Prostatic acid phosphatase (ACP3) is overexpressed in more than 85% of prostate cancers, and largely abse...
IFCT-2401 SPORADIC trial: Integrating cemiplimab to sequential hypofractionated chemoradiotherapy for unfit or elderly patients with unresectable stage III non–small cell lung cancer.
TPS8128 Background: Patients with unresectable stage III non-small cell lung cancer (NSCLC) who are elderly or have signif...
Extent of resection and survival in <i>IDH</i> -mutant WHO grade 2 glioma: A systematic review and meta-analysis.
e14098 Background: For IDH-mutant WHO grade 2 gliomas, extent of resection (EOR) is thought to improve long-term outcomes,...
Digital health intervention for comorbid insomnia and neurocognitive impairment in adult survivors of childhood cancer: Results from a randomized clinical trial.
10003 Background: Survivors of childhood cancer are at risk of developing both insomnia and cognitive impairment, which ma...
KIF11 as a druggable target in NSCLC: An integrated computational analysis.
e20716 Background: Non-small cell lung cancer (NSCLC) in non-smoking women represents a biologically distinct subgroup in...
Efficacy and safety of neoadjuvant chemotherapy with AG regimen with or without nimotuzumab in borderline resectable or locally advanced pancreatic cancer: A retrospective cohort study.
e16375 Background: This study aimed to evaluate whether adding nimotuzumab to an albumin-bound paclitaxel plus gemcitabine...
Prevalence of <i>CDH1</i> germline variants in gastric cancer patients with exome-inferred ancestry.
4073 Background: Germline pathogenic or likely pathogenic (P/LP) CDH1 variants inc...
Testicular plasmacytoma: A comprehensive case series and review.
e19565 Background: Testicular plasmacytoma (TP) is a rare manifestation of plasma cell neoplasms, occurring alone or with...
Bridging the cardio-oncology care gap in India: Real-world guideline adherence and AI-driven workflow optimization in 2300 breast cancer patients at a tertiary cardiac center.
e12719 Background: Cardiotoxic cancer therapies necessitate guideline-recommended cardiac surveillance in breast cancer pa...
A multiple-instance learning-based deep learning model with multi-channel input for early detection of breast tumor.
e12576 Background: Early detection of breast cancer is essential but remains limited by the high cost. Echo signal–based a...