Journal of Clinical Oncology
Articles in this Issue
Improving cancer outcomes through equity: Interventions tailored for Hispanic families.
e13556 Background: People of Hispanic and Latino/a/x ethnicity (collectively referred to here as “Hispanic”) who are livin...
Cervical cancer epidemiology in high-income nations (1990-2023): Three decades of prevention success and emerging disparities.
e17532 Background: Cervical cancer rates and deaths have dropped significantly in high-income countries after the start of...
Dynamic, tumor-agnostic ctDNA analysis for MRD detection and longitudinal monitoring in pleural mesothelioma: The Janus-seq academic workflow.
e20065 Background: Pleural mesothelioma (PM) is an aggressive thoracic malignancy with poor prognosis and limited tools fo...
Association of immune-mediated hepatitis with immune checkpoint inhibitor regimens in advanced hepatocellular carcinoma.
e16200 Background: Immune checkpoint inhibitors (ICIs) are standard for unresectable/advanced hepatocellular carcinoma (HC...
A phase I trial evaluating an optimized B7-H3xCD3 T cell engager for treatment of solid cancer.
TPS2667 Background: T cell-based immunotherapy has revolutionized oncological treatment of various malignancies. However,...
Overall survival of first-line amivantamab plus lazertinib in atypical <i>EGFR</i> -mutated advanced non-small cell lung cancer (NSCLC): Updated results from the CHRYSALIS-2 study.
8501 Background: Patients with atypical EGFR -mutated advanced NSCLC have worse lo...
A novel Bayesian approach for assessing associations between ECOG performance status (ECOG-PS) and patient-reported outcomes (PROs) in patients with gastric or gastroesophageal junction (GC/GEJC) adenocarcinoma: Post hoc analysis from the RATIONALE-305 trial.
e16044 Background: Oncology clinicians rely on ECOG-PS to guide trial eligibility and monitor disease impact, yet it provi...
Cancer screening and site-specific mortality in adults aged ≥ 65 years: A systematic review.
e23182 Background: Cancer screening in older adults is often guided by age-based policies; however, increasing life expect...
Shifting burden of cardiomyopathy deaths among United States cancer patients: A 25-year CDC WONDER analysis.
e24009 Background: Cardiomyopathies (CM) are increasingly recognized among patients with cancer. They may develop due to t...
Bronchoscopic pulsed electric field ablation for locally advanced and metastatic NSCLC: A six-patient real-world experience from a rural community hospital.
e23399 Background: ALIYA pulsed electric field (PEF) ablation is a bronchoscopic, non-thermal local therapy designed to in...
STING agonist JMKX000197 infusion in patients with malignant pleural effusion: Preliminary results from a prospective phase Ib study.
2598 Background: Indwelling pleural catheter (IPC) is frequently used for symptomatic malignant pleural effusion (MPE), it...
Reduced-intensity versus intensive induction in high-risk acute promyelocytic leukemia: A systematic review and meta-analysis.
e18521 Background: High-risk acute promyelocytic leukemia (APL), defined by WBC >10×10⁹/L, accounts for 20-30% of cases...
Osteoporosis and osteoporosis-related fractures among older male cancer patients: A nationwide study.
11196 Background: Osteoporosis is commonly viewed as a disease of postmenopausal women, leading to significant underdiagno...
Global disparities in current clinical trials in cervical cancer.
5530 Background: Cervical cancer is one of the most disproportionately distributed cancers worldwide, with highest inciden...
Neoadjuvant almonertinib followed by chemo-immunotherapy in II-IIIb EGFR-mutant NSCLC: A single arm, phase II study (NEOVADE).
8509 Background: Neoadjuvant target therapy has improved objective response rate (ORR) or major pathological response (MPR...
A phase 2 study of docetaxel (D), ramucirumab (R), and pembrolizumab (P) for patients with metastatic or recurrent non–small cell lung cancer (NSCLC) who progressed on platinum-doublet and PD-1/PD-L1 blockade.
8594 Background: NSCLC treatment (trt) efficacy remains modest after progression on platinum and immune checkpoint inhibit...
Epcoritamab (epcor) + chemoimmunotherapy (CIT) in patients (pts) with relapsed/refractory large B-cell lymphoma (R/R LBCL) eligible for autologous stem cell transplant (ASCT): Pooled results from arms 4 and 10 of EPCORE NHL-2.
7061 Background: Pts with R/R LBCL can have inadequate response to salvage treatment (tx), precluding ASCT. While CAR T th...
Comparative safety profiles of frontline BTK inhibitor–containing regimens in mantle cell lymphoma: A cross-trial analysis of phase III studies.
e19049 Background: Bruton tyrosine kinase inhibitors (BTKis) are increasingly incorporated into frontline mantle cell lymp...
Survival of hematologic malignancy in patients with early-stage chronic kidney disease (SHIP-CKD).
7089 Background: Chronic kidney disease (CKD) is a common comorbidity among cancer patients and may influence treatment op...
Redox status of endometrial tumors: A comparative study in endometrioid adenocarcinoma, serous, and clear cell carcinomas.
e17619 Background: Oxidative stress, reflecting an imbalance between the formation of reactive oxygen species and the body...
Anatomical and clinical heterogeneity of dMMR colorectal cancer by tumor location.
e15725 Background: Deficient mismatch repair (dMMR) colorectal cancer is a biologically heterogeneous disease. Tumors from...
Phase II trial of olaparib and ceralasertib in patients with recurrent osteosarcoma: Lung-only resectable cohort efficacy and correlative biomarker results.
10015 Background: Patients with osteosarcoma recurrence have limited treatment options and poor outcomes. The observed res...
Efficacy, survival, and safety of neoadjuvant immune checkpoint inhibitors plus chemotherapy in early breast cancer: A systematic review and meta-analysis of randomized and real-world comparative studies.
e12679 Background: Neoadjuvant chemotherapy is a standard approach for high-risk early breast cancer, with pathologic comp...
Diagnostic and prognostic performance of urinary metabolomic biomarkers in lung cancer: A systematic review and meta-analysis.
e20551 Background: Urinary biomarkers offer a non-invasive strategy for the detection and prognostication of lung cancer;...
Clinical and pathological outcomes of patients with germ-cell tumor undergoing surgical resection of residual disease after high-dose chemotherapy.
e17012 Background: In patients (pts) with germ-cell tumor (GCT) treated with high-dose chemotherapy (HDCT) and peripheral-...