Journal of Clinical Oncology
Articles in this Issue
Global and regional economic burden of alcohol-attributable cancers: A benchmarking analysis.
e23105 Background: Alcohol consumption is responsible for 6–8% of global cancer deaths, but comprehensive regional economi...
The TIME trial: Phase II randomized controlled trial of time-of-day–specified nivolumab and ipilimumab for advanced melanoma.
TPS2677 Background: Nivolumab/ipilimumab is standard of care for advanced melanoma patients based on Phase III randomized...
A prospective observational study to compare the efficacy, time toxicity, and cost of conventional 3+7 regimen versus azacitidine + venetoclax (AZA + VEN) as induction therapy in patients with acute myeloid leukemia (AML).
6511 Background: In low-middle income countries, 3+7 induction therapy for AML is associated with high induction mortality...
Real-world time-to-event detection of immune-related adverse events from electronic health records using clinical natural language processing.
e13650 Background: Immune-related adverse events (irAEs) are a major challenge in immune checkpoint inhibitor (ICI) therap...
Liver transplantation for unresectable colorectal liver metastases: A systematic review and meta-analysis of survival outcomes.
e15548 Background: Patients with unresectable colorectal liver metastases (uCRLM) have limited long-term survival with con...
Febrile neutropenia prophylaxis with prolonged G-CSF in elderly cancer patients: Analysis from the EMPREREAL study.
e13773 Background: Guidelines consider age ≥ 65 years a key factor in recommending primary prophylaxis with granulocyte co...
Temporal trends in early-phase oncology trials in Brazil.
e23427 Background: With improvements in regulatory frameworks, early-phase oncology research is increasingly expanding int...
Distribution and density of tertiary lymphoid structures as predictors of clinical outcomes and immunotherapy responses in gallbladder cancer.
4127 Background: Gallbladder cancer (GBC) is an aggressive malignancy with limited treatments and is often immunologically...
Generalized integral transform technique (GITT) in tumor dynamics: A technical qualitative review for translational oncology.
e13645 Background: Mathematical models of tumor growth, invasion, cell–matrix interactions, and therapeutic response commo...
Indirect comparison of nivolumab-ipilimumab versus chemotherapy (Chemo) and/or immunotherapy in dMMR/MSI-H metastatic colorectal cancer (mCRC) using reconstructed individual patient data (IPD).
3579 Background: In patients with dMMR/MSI-H mCRC, phase III randomized trials have established immune checkpoint (IO) inh...
Tislelizumab combined with donafenib and GEMOX as first-line treatment for advanced biliary tract cancer: A single-arm, phase II study.
4110 Background: Advanced biliary tract cancer (BTC) progresses rapidly and has a poor prognosis, with a 5-year survival r...
Clinical risk factors and outcomes of tumor lysis syndrome in hospitalized patients with malignancy.
e18635 Background: Tumor lysis syndrome (TLS) is a serious oncologic emergency that can occur in both hematologic and soli...
Initial analysis of adoptive neoantigen-specific T-cell immunotherapy for MGMT-unmethylated glioblastoma (TVI-AST-008): Signals amid control arm attrition.
2042 Background: MGMT-unmethylated (MGMT-u) glioblastoma (GBM) confers resistance to alkylating agents and poor overall su...
Lymphopenia in breast cancer and association with clinical outcomes: An analysis from over 30,000 patients.
640 Background: Lymphopenia is an independent prognostic factor for overall survival in patients with solid tumors. Low ci...
Implementing flexible and adapted follow-up strategies in a patient-centric, phase II trial of first-line lorlatinib for advanced ALK-positive non–small cell lung cancer (CTONG2203).
e13545 Background: We initiated the first patient-centric, multicenter, phase II trial (CTONG2203, NCT 06092086) to invest...
Genomic biomarkers of sensitivity to bipolar androgen therapy (BAT) in metastatic castration-resistant prostate cancer (mCRPC).
5064 Background: In most cases, mCRPC remains driven by persistent androgen receptor (AR)-signaling. BAT has shown benefit...
Real-world evaluation of a deep learning–based serial CT imaging biomarker with variable thoracic and abdominopelvic coverage in metastatic colorectal and kidney cancers.
e15512 Background: Early on-treatment biomarkers that predict overall survival may benefit treatment decisions and clinica...
First-in-human phase I/II study of EN002-gel, a first-in-class drip inhibitor, in non-melanoma skin cancer and actinic keratosis.
e21567 Background: The high global incidence of skin cancer severely impairs patients' quality of life and even poses a li...
Impact of advanced pneumatic compression devices and usual care on psychosocial outcomes in head and neck cancer survivors with lymphedema.
6109 Background: Head and neck cancer (HNC)-associated lymphedema impairs quality of life (QOL) in survivors, affecting bo...
Survival and hematologic outcomes in prostate cancer patients with radiation cystitis receiving hyperbaric oxygen therapy: A propensity-matched analysis.
e17138 Background: Radiation cystitis is a common complication in prostate cancer patients receiving radiotherapy. Hyperba...
Prediction of lymphovascular invasion in breast carcinoma using MRI-based radiomics: A systematic review and meta-analysis.
e12560 Background: Lymphovascular invasion (LVI) correlates with poor breast cancer prognosis, indicating metastatic progr...
Admission acuity and inpatient outcomes among hospitalizations for pancreatic cancer in the United States, 2018–2022.
e16352 Background: Pancreatic cancer is associated with high morbidity and frequent hospitalization. National data describ...
National patterns of overtreatment in low-risk and undertreatment in high-risk prostate cancer and associated survival impact.
e17027 Background: Guidelines recommend active surveillance for low-risk prostate cancer and definitive therapy for high-r...
Efficacy and safety of Meilian Fuxin liquid for radiation-induced oral mucositis in head and neck cancer: A multicenter randomized clinical trial.
12145 Background: Radiation-induced oral mucositis (RIOM) is common during head and neck radiotherapy ( > 90% incidence...
Real-world outcomes of triplet therapy with hypomethylating agent, venetoclax, and FLT3 inhibitor versus doublet therapy in FLT3-mutated acute myeloid leukemia.
e18532 Background: FLT3-mutated acute myeloid leukemia (AML) is associated with inferior outcomes, particularly among olde...