Browse Articles

Study on the crack propagation morphology and initiation law of coal rock under the action of underwater electric pulse

Biomechanical analysis of a short femoral stem used in revision total hip replacement of a standard femoral stem

A between-subjects investigation of whether distraction is the main mechanism behind music-induced analgesia

SDES-YOLO: A high-precision and lightweight model for fall detection in complex environments

A theoretical investigation of spectroscopy properties and transition properties of TlBr+ cation

Genetic proxies for clinical traits are associated with increased risk of severe COVID-19

Abstract Routine use of genetic data in healthcare is much-discussed, yet little is known about its performance in epidemiological models including traditional risk factors. Using severe COVID-19 as an exemplar, we explore the integration of polygenic risk scores (PRS) into disease models alongside sociodemographic and clinical variables. PRS were optimized for 23 clinical variables and related traits previously-associated with severe COVID-19 in up to 450,449 UK Biobank participants, and tested in 9,560 individuals diagnosed in the pre-vaccination era. Associations were further adjusted for (i) sociodemographic and (ii) clinical variables. Pathway analyses of PRS were performed to improve biological understanding of disease. In univariate analyses, 17 PRS were associated with increased risk of severe COVID-19 and, of these, four remained associated with COVID-19 outcomes following adjustment for sociodemographic/clinical variables: hypertension PRS (OR = 1.1, 95%CI 1.03–1.18), atrial fibrillation PRS (OR = 1.12, 95%CI 1.03–1.22), peripheral vascular disease PRS (OR = 0.9, 95%CI 0.82–0.99), and Alzheimer’s disease PRS (OR = 1.14, 95%CI 1.05–1.25). Pathway analyses revealed enrichment of genetic variants in pathways for cardiac muscle contraction (genes N  = 5; beta[SE]  = 3.48[0.60]; adjusted -P  = 1.86 × 10 −5 ). These findings underscore the potential for integrating genetic data into epidemiological models and highlight the advantages of utilizing multiple trait PRS rather than a single PRS for a specific outcome of interest.

A mediating role of visceral adipose tissue on the association of health behaviours and metabolic inflammation in menopause: a population-based cross-sectional study

Recycling of endocytic BDNF through extracellular vesicles in astrocytes

Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies

Retraction Note: An intelligent dynamic cyber physical system threat detection system for ensuring secured communication in 6G autonomous vehicle networks

Screening of Aβ and phosphorylated tau status in the cerebrospinal fluid through machine learning analysis of portable electroencephalography data

Spaciotemporal distribution characteristics of glacial lakes and the factors influencing the Southeast Tibetan Plateau from 1993 to 2023

Clinical characteristics and laparoscopic management experience of primary ovarian leiomyoma

Streptococcus pyogenes carriage rate, associated factors and antimicrobial susceptibility profiles among urban and rural schoolchildren at Gondar city, Northwest Ethiopia

VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis

Oligogenic effect is associated with the clinical heterogeneity of autosomal dominant deafness-15

Analysis of changes in the chemokine CXC ligand 13 in serum and cerebrospinal fluid of patients with neuromyelitis optica

Long-term trends in the incidence of male breast cancer and nomogram for predicting survival in male breast cancer patients: a population-based epidemiologic study

Reduction in thermal conductivity of monolayer MoS2 by large mechanical strains for efficient thermal management

Daily briefing: New obesity definition sidelines BMI to focus on health