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Investigation of the optimum calcination temperature for water treatment plant sludge to develop a sustainable alkali activated concrete
Abstract Nowadays, Egypt is treating the Nile River Water to produce drinking water, and this process generates large amounts of waste, around 635 million m3 annually, which is called water treatment plant sludge (WTPS). This WTPS cost the government around 30 million US dollars to return it back to the Nile River in addition to negatively affecting the environment. Therefore, there is an urgent need to find environmentally friendly alternatives that reduce the impact of such an issue. This paper focuses on treating WTPS by drying, grinding and calcining to develop it as an alternative binder for use in alkali-activated concrete. This approach would not only provide green construction material but also reveal an environmental disposal route for the sludge produced in Egypt or in any country has the same issue. The treatment methodology used in this study was based on finding the optimum calcination temperature regime for WTPS after drying and grinding. Fifteen specimens of WTPS powder were used to investigate the optimum calcination temperature and duration by applying different temperatures ranging from 500 °C to 800 °C for various exposure durations of 30, 60 and 90 min. XRD and Chapelle tests were employed to chemically investigate the efficiency of the obtained calcined WTPS specimens, while strength activity index and compressive strength tests were used to mechanically verify the findings of the chemical tests. The results indicated that the calcination regime, which involved applying a maximum temperature of 650 °C for 90 min, achieved the best chemical characteristics and a strength activity index of 145%. Moreover, this regime resulted in a compressive strength of 21 MPa when WTPS powder was used as a precursor in alkali-activated concrete. Additionally, this paper presented a brief comparison of the production cost and energy consumption between cement and WTPS. The comparison demonstrated the efficiency of using WTPS as a replacement for cement, showing that the production of WTPS costs 50% less and consumes 92% less energy than cement.
NASA still has no plan for how to bring precious Mars rocks to Earth
Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital
Resin composite aggregated S-PRG particles are not superior to non-S-PRG under microcosm biofilm
A simplified computational liver perfusion model, with applications to organ preservation
Abstract Advanced liver preservation strategies could revolutionize liver transplantation by extending preservation time, thereby allowing for broader availability and better matching of transplants. However, developing new cryopreservation protocols requires exploration of a complex design space, further complicated by the scarcity of real human livers to experiment upon. We aim to create computational models of the liver to aid in the development of new cryopreservation protocols. Towards this goal, we present an approach for generating 3D models of the liver vasculature by building upon the space colonization algorithm. Additionally, we introduce the concept of a super lobule which enables a computational abstraction of biological liver lobules. User-tunable parameters allow for vasculatures of varying depth and topology to be generated. In each model, we solve for a common lumped resistance value assigned to the super lobules, allowing the overall physiological blood pressure and flow rate through the liver to be preserved. We demonstrate our approach’s ability to maintain consistency between models of varying depth. Finally, we simulate steady state machine perfusion of the generated models and demonstrate how they can be used to quickly test the effect of different boundary conditions when designing organ preservation protocols.
Author Correction: Performances and determinants of proficiency testing in clinical laboratory services at comprehensive specialized hospitals, northwest Ethiopia
Analytical model for helical particle array assessment for EMI shielding applications
Uniaxial compressive damage evolution and constitutive modeling of fissure-like rocks under different loading rates based on acoustic emission
Particle accelerators get an assist from AI co-pilots
Optimal parameter identification of photovoltaic systems based on enhanced differential evolution optimization technique
RED light promotes flavonoid and phenolic accumulation in Cichorium spp. callus culture as anti-candida agent
Abstract Chicory species, particularly Cichorium endive Supp. Pumillum, also, known as Egyptian chicory, are globally recognized for their rich content of bioactive secondary metabolites such as flavonoids and phenolics. These metabolites are highly valued for their pharmaceutical, dietary, and commercial applications. Light exposure, particularly through red and blue wavelengths, is a potent natural elicitor that influences the biosynthesis of secondary metabolites and impacts plant morphology. This study investigates the effects of red and blue LED light exposure on the callus culture of Egyptian chicory (Cichorium endive Supp. Pumillum), with the aim of enhancing flavonoid accumulation for potential use as an anti-Candida agent. Callus cultures of Cichorium intybus, Cichorium endive Supp. Pumillum, and Taraxacum officinale (Italian chicory) were grown on MS media supplemented with 4 mg/L 2iP and 0.5 mg/L NAA for 4 weeks. The cultures were then exposed to 12 days of red and blue LED light. After extraction using liquid nitrogen and methanol, the resulting callus extracts were tested against Candida albicans NRRL477 at various concentrations (1/8, 1/4, and 1/2 MIC) for 20 to 120 min. The antifungal activity was assessed by determining the effects on acid-soluble phosphorus, total lipids, and soluble proteins in the Candida cells. Our results demonstrate that the red LED light-exposed Cichorium endive Supp. Pumillum callus extract exhibited the most potent antifungal activity, significantly inhibiting the growth of Candida species compared to blue light and control treatments. Notably, the red light-treated callus culture accumulated higher concentrations of flavonoids and phenolic compounds, which contributed to its effectiveness as an anti-Candida agent. These findings suggest that LED red light elicitation is an effective method for enhancing the production of bioactive compounds in Egyptian chicory, offering potential for its use in natural antifungal therapies. Future research will explore the mechanistic pathways of flavonoid accumulation under different light conditions and investigate the broader applications of this elicitation technique for other medicinal plants.
Author Correction: RNASeq analysis of drought-stressed guayule reveals the role of gene transcription for modulating rubber, resin, and carbohydrate synthesis
‘WithdrarXiv’ database of 14,000 retracted preprints launches
Progress in quality assessment of Italian saffron
Biochar and bentonite application improves aeolian sandy soil health and enhances soil carbon sequestration and emission reduction potential
Earth shattered heat records in 2023 and 2024: is global warming speeding up?
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy
Abstract Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with myocardial hypertrophy, fibrosis and ventricular dysfunction. Hypoxia-inducible transcription factor-1α (Hif-1α) is the central master regulators of cellular hypoxia response and associated with HCM. Yet its exact role remains to be elucidated. Therefore, the effect of a cardiomyocyte-specific Hif-1a knockout (cHif1aKO) was studied in an established α-MHC719/+ HCM mouse model that exhibits the classical features of human HCM. The results show that Hif-1α protein and HIF targets were upregulated in left ventricular tissue of α-MHC719/+ mice. Cardiomyocyte-specific abolishment of Hif-1a blunted the disease phenotype, as evidenced by decreased left ventricular wall thickness, reduced myocardial fibrosis, disordered SRX/DRX state and ROS production. cHif1aKO induced normalization of pro-hypertrophic and pro-fibrotic left ventricular remodeling signaling evidenced on whole transcriptome and proteomics analysis in α-MHC719/+ mice. Proteomics of serum samples from patients with early onset HCM revealed significant modulation of HIF. These results demonstrate that HIF signaling is involved in mouse and human HCM pathogenesis. Cardiomyocyte-specific knockout of Hif-1a attenuates disease phenotype in the mouse model. Targeting Hif-1α might serve as a therapeutic option to mitigate HCM disease progression.