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Indoloindolizines: The Complete Story of a Polycyclic Aromatic Scaffold from Theoretical Design to Organic Field-Effect Transistor Applications
Core decompression assisted by multi-functional minimally invasive instruments for the treatment of early osteonecrosis of the femoral head
Abstract Core decompression is a common method for treating early osteonecrosis of the femoral head (ONFH). However, the surgical procedure is cumbersome due to the lack of appropriate surgical instruments. This study aims to modify surgical instruments to improve surgery efficiency. A total of 28 patients with early ONFH treated with the core decompression were enrolled. 13 cases were treated with new instruments and the other 15 cases were treated with the traditional methods. The convenience of the new instruments was evaluated by comparing evaluation indicators. The multi-functional instruments reduced the number of fluoroscopy, shorted the operation time, improved the delivery efficiency, reduced the intraoperative blood loss, and reduced the surgical incision compared with the traditional method (p < 0.05). The new instruments removed the healthy bone of the femoral head and neck for reuse, the overall hospitalization cost was lower, and patient satisfaction was higher (p < 0.05). In the postoperative follow-up, the VAS was lower and Harris score was higher compared with the traditional group (p < 0.05). The multi-functional instruments can achieve the advantages of accurate positioning of the necrotic area, removed and reused healthy bone, effective expanded decompression, and efficient implant delivery, which is the effective instrument for the early ONFH.
The Stereoselectivity of Neighboring Group-Directed Glycosylation Is Concentration-Dependent
Association between breast cancer risk factors and blood microbiome in patients with breast cancer
Abstract This study investigated the relationship between risk factors for breast cancer (BC) and the microbiome by comparing the microbiomes of BC patients with fatty liver disease to those with a normal liver. Bacterial extracellular vesicles were collected from each blood sample, and next-generation sequencing was performed. The analysis identified specific microbiome profiles shared among groups with hyperglycaemia, hyperlipidaemia, and high body mass index (BMI), which were then compared with functional biomarkers. In particular, the genus Faecalibacterium was a specific bacterium found in the groups with high concentrations of low-density lipoprotein cholesterol, high BMI, and fatty liver disease. Therefore, when the prognosis of patients with BC was analysed based on Faecalibacterium presence, it was confirmed that patients’ prognoses tended to deteriorate. In this study, BC risk factors, such as hyperglycaemia, hyperlipidaemia, fatty liver, and high BMI, were interconnected through the microbiome. This provides insights into how the risk factors for BC are linked and their impact on the microbiome and human health.