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Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems

Journal of Biological Chemistry Vijay Kumar M. J, Jérémie Mitteaux, Zi Wang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108040

The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

Nature Reviews Drug Discovery Josepine Fernow, Marie Olliver, William Couet et al. Jan 01, 2025 DOI: 10.1038/d41573-024-00138-9

One-for-all gene inactivation via PAM-independent base editing in bacteria

Journal of Biological Chemistry Xin Li, Ying Wei, Shu-Yan Wang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108113

The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy

Journal of Biological Chemistry Tian-Wen Liu, Can Tian, Yan-Xue Li et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108093

Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains

Journal of Biological Chemistry Huan Yang, Ge Zheng, Grace Y. Li et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108077

Spatial chromosome organization and adaptation of the radiation-resistant extremophile Deinococcus radiodurans

Journal of Biological Chemistry Qin-Tian Qiu, Cai-Yun Zhang, Zhi-Peng Gao et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108068

The signaling landscape of insulin-like growth factor 1

Journal of Biological Chemistry Muhammad Zahid Khan, Jose Luis Zugaza, Ignacio Torres Aleman Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108047

Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability

Journal of Biological Chemistry Jing Wang, Yida Wang, Huan Xiao et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108050

Thrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC

Journal of Biological Chemistry Subhojit Paul, Akash Chatterjee, Kaushik Das et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108025

Structural basis for the pathogenicity of parkin catalytic domain mutants

Journal of Biological Chemistry Julian P. Wagner, Véronique Sauvé, Anshu Saran et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108051

A conserved acidic residue drives thyroxine synthesis within thyroglobulin and other protein precursors

Journal of Biological Chemistry Camilla Stejskalova, Federica Arrigoni, Riccardo Albanesi et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108026

Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis

Journal of Biological Chemistry Xuehuan Wen, Songjie Bai, Guirun Xiong et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108085

Purification of micrococcal nuclease for use in ribosomal profiling of high-salinity extremophiles

Journal of Biological Chemistry Pavlina Gregorova, Matthew Isada, Jocelyne DiRuggiero et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108020

mRNA vaccine sequence and structure design and optimization: Advances and challenges

Journal of Biological Chemistry Lei Jin, Yuanzhe Zhou, Sicheng Zhang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108015

Iron regulatory protein 1-deficient mice exhibit hypospermatogenesis

Journal of Biological Chemistry Aileen Harrer, Niraj Ghatpande, Tiziana Grimaldini et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108067

Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Journal of Biological Chemistry Therése Klingstedt, Hamid Shirani, Farjana Parvin et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108032

The structural basis for high-affinity c-di-GMP binding to the GSPII-B domain of the traffic ATPase PilF from Thermus thermophilus

Journal of Biological Chemistry Konstantin Neißner, Heiko Keller, Lennart Kirchner et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108041

The putative polyamine transporter Shp2 facilitates phosphate export in an Xpr1-independent manner and contributes to high phosphate tolerance

Journal of Biological Chemistry Tochi Komamura, Tomoki Nishimura, Naoki Ohta et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108056

PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells

Journal of Biological Chemistry Yue Huang, Yuting Zhang, Yuan Liu et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108111

Phosphorylation of Ephexin4 at Ser-41 contributes to chromosome alignment via RhoG activation in cell division

Journal of Biological Chemistry Ryuji Yasutake, Hiroki Kuwajima, Ryuzaburo Yuki et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108084