Browse Articles

Advantages of different dietary supplements for elite combat sports athletes: a systematic review and Bayesian network meta-analysis

Key frame extraction algorithm for surveillance videos using an evolutionary approach

Sulfur-locked multiple resonance emitters for high performance orange-red/deep-red OLEDs

The influence of ammonia-N and salinity levels on oxidative stress markers, hepatic enzymes, and acid phosphatase activity in Nile tilapia (Oreochromis niloticus)

Data-driven automated job shop scheduling optimization considering AGV obstacle avoidance

All-solid-state batteries designed for operation under extreme cold conditions

5,7-Dihydroxyflavone acts on eNOS to achieve hypotensive effects in spontaneously hypertensive rats

Polypharmacy or potentially inappropriate medications among older adults with COVID-19 in a secondary hospital in China and their association with mortality

A soft thermal sensor for the continuous assessment of flow in vascular access

AbstractHemodialysis for chronic kidney disease (CKD) relies on vascular access (VA) devices, such as arteriovenous fistulas (AVF), grafts (AVG), or catheters, to maintain blood flow. Nonetheless, unpredictable progressive vascular stenosis due to neointimal formation or complete occlusion from acute thrombosis remains the primary cause of mature VA failure. Despite emergent surgical intervention efforts, the lack of a reliable early detection tool significantly reduces patient outcomes and survival rates. This study introduces a soft, wearable device that continuously monitors blood flow for early detection of VA failure. Using thermal anemometry, integrated sensors noninvasively measure flow changes in large vessels. Bench testing with AVF and AVG models shows agreement with finite element analysis (FEA) simulations, while human and preclinical swine trials demonstrate the device’s sensitivity. Wireless adaptation could enable at-home monitoring, improving detection of VA-related complications and survival in CKD patients.

Modifiable Risk Factors for Stroke in Syria: A Nationwide Multi-centre Case-Control Study

Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns

NHSL3 controls single and collective cell migration through two distinct mechanisms

AbstractThe molecular mechanisms underlying cell migration remain incompletely understood. Here, we show that knock-out cells for NHSL3, the most recently identified member of the Nance-Horan Syndrome family, are more persistent than parental cells in single cell migration, but that, in wound healing, follower cells are impaired in their ability to follow leader cells. The NHSL3 locus encodes several isoforms. We identify the partner repertoire of each isoform using proteomics and predict direct partners and their binding sites using an AlphaFold2-based pipeline. Rescue with specific isoforms, and lack of rescue when relevant binding sites are mutated, establish that the interaction of a long isoform with MENA/VASP proteins is critical at cell-cell junctions for collective migration, while the interaction of a short one with 14-3-3θ in lamellipodia is critical for single cell migration. Taken together, these results demonstrate that NHSL3 regulates single and collective cell migration through distinct mechanisms.

Comparative genetic diagnostic evaluation of pediatric neuromuscular diseases in a consanguineous population

A low switching loss GaN trench MOSFET design utilizing a triple-shield structure

Room-temperature creation and conversion of individual skyrmion bags in magnetic multilayered disks

Chemical insight into pros and cons of coffees from different regions

A fast parameter estimation method for high-frequency oscillation based on empirical wavelet transform and moving least square

Soft Metalens for Broadband Ultrasonic Focusing through Aberration Layers

Superconductivity in ordered Li–Al–B compounds

AbstractUsing first principles calculations, we show that $$\hbox {Li}_x\hbox {Al}_y\hbox {B}_{2(x+y)}$$ materials have strong electron-phonon coupling, with many having a superconducting critical temperature ($$T_c$$) that exceeds that of the more familiar $$\hbox {MgB}_2$$ at ambient pressure. In particular, we find that $$\hbox {LiAlB}_4$$ is the most stable member of the family, with $$T_c > 44\,\hbox {K}$$ whilst the peak $$T_c$$ is with $$\hbox {Li}_3\hbox {AlB}_8$$ which has $$T_c > 77\,\hbox {K}$$. Our results reveal that these materials are both thermodynamically and dynamically stable, with strong electron-phonon coupling, indicating significant potential for practical superconducting applications.

Long COVID in transgender and gender nonbinary people in the United States