Browse Articles

Preservation and alteration of inclusion-based calcite-water oxygen isotope and clumped isotope temperature signals in calcite veins

Abstract Knowledge of the formation temperatures of geological deposits is essential for investigating their genesis. Oxygen isotope thermometry (OIT), using the temperature dependence of oxygen isotope fractionation between host carbonate mineral and mineral-forming water trapped in fluid inclusions, and clumped isotope thermometry, based on the degree of 13C and 18O clumping, are receiving increasing interest. However, only a few studies have applied combinations of these methods, and their databases are limited. In this study, we compare OIT and clumped isotope temperatures obtained for 18 samples from Mesozoic to early Cenozoic calcite veins. Our analysis indicates that the formation temperatures were preserved in the clumped isotopic compositions (16–45 °C), whereas the OIT temperatures were shifted to lower temperatures (− 2 to 33 °C). An OIT temperature shift occurred, due to a retrograde oxygen isotope exchange between the fluid inclusion water and the host calcite. These results imply that the retrograde isotope exchange should be taken into consideration, even for low-temperature carbonate deposits, if a sufficiently long time is available.

Intraoperative use of high-speed Raman spectroscopy during soft tissue sarcoma resection

Engineering the coordination environment of Ni and Pd dual active sites for promoting the oxygen reduction reaction

A simple pathway for complete polarization vision

Novel composite bone cement modulates inflammatory response in vitro

Assessment of livelihood vulnerability to climate change among tribal communities in Chhindwara and Dhar district, Central India

Anatomical consideration for botulinum toxin injection of the frontalis muscle based on analysis of intramuscular innervation

Abstract The facial nerve is the seventh cranial nerve, and its temporal branch (TBFN) innervates the frontalis muscle. Peripheral nerve disorders involving the facial nerve can lead to facial palsy, for which a common non-invasive treatment approach is to inject a chemodenervation agent such as botulinum toxin (BoNT). The purpose of this study was to provide anatomical suggestions for BoNT injection sites in the frontalis muscle based on the intramuscular innervation pattern of the TBFN as identified objectively using Sihler’s staining. Nineteen hemifaces containing the TBFN and the frontalis muscle were harvested from 15 embalmed cadavers according to facial landmarks. The frontalis muscle was divided into 16 areas to identify the prevalence rates of distal nerve endings and the arborization pattern of the TBFN after applying Sihler’s staining. Distal nerve endings of the TBFN were most commonly found in area B2 (17 of 19 specimens, 89.5%), followed by in area B3 ( n  = 15, 78.9%). No distal nerve ending was observed in area A1. Two types of the arborization pattern of the TBFN were observed. We propose four BoNT injection sites based on the intramuscular innervation pattern of the TBFN in the frontalis muscle as identified using Sihler’s staining.

Clinical evaluation of a polarization-based optical noninvasive glucose sensing system

Genetic survey of crucian carp Carassius carassius populations in Hungary for a conservation project to establish live gene bank

Abstract The crucian carp (Carassius carassius Linnaeus, 1758) is a declining native European cyprinid, inhabiting small water bodies, primariliy threatened by climate change, anthropogenic impacts and invasive relative the Prussian carp. Despite conservation efforts across Europe, data on Carphatian Basin populations remain scarce. This study analyzed nine natural populations (257 individuals) in Hungary using thirteen microsatellite markers and mitochondrial DNA COI sequencing (187 individuals). Sequencing of mitochondrial DNA revealed a presumably introduced Baltic stock in addition to the Danube lineage and the presence of Prussian carp hybrids in part of the populations. Microsatellite markers also confirmed the latter, but there were populations in the southern region free of hybrids. Genetic diversity was found to be moderate (Ho: 0.49–0.61; Ar: 6.01–7.98). Depending on the genetic structure analysis method, two or three main units with low to moderate differentiation were detected (FST: 0.054–0.192). Based on gene flow, the Danube-Drava region showed a separation from the northern areas and the populations on the eastern bank of the Danube. Eight of the nine populations examined, especially the south Danube populations, could provide a good basis for the establishment of a genetically controlled gene bank of remaining crucian carp stocks, without hybrids.

Overexpression of miR-99a promoted expansion and suppressed differentiation of hematopoietic stem/progenitor cells

Spatial clustering and determinants of zero-utilization of antenatal care among pregnant women in Ethiopia

Multi-body sensor based drowsiness detection using convolutional programmed transfer VGG-16 neural network with automatic driving mode conversion

Lagrangian modelling reveals sediment pathways at evolving coasts

Abstract Coastal regions face increasing pressure from climate change, sea-level rise, and growing coastal populations. This “coastal squeeze” threatens both the systems’ sustainability and their ecosystem services. Coastal changes depend on the distribution of sediment throughout the system, which evolves continuously through complex transport processes. While we can quantify net morphological changes, this alone provides incomplete understanding of coastal evolution as similar morphological states can result from vastly different sediment movement patterns. Coastline perturbations-deviations from straight coastlines ranging from beach cusps to headlands, deltas, and artificial nourishments-exemplify this challenge. Although their diffusive morphological evolution is well understood, we have limited knowledge of the underlying sediment movement patterns driving this change. This study reveals how coastline perturbations alter sediment transport by tracing particles from origin to destination using Lagrangian tracking at the Sand Engine mega-nourishment. Our results demonstrate that perturbations alter both sediment dispersal and accumulation. During initial stages, the longshore dispersal of sediment is strongly restricted by rapid deposition and burial on both sides of the perturbation. A backward-tracing approach reveals that sediment deposition not only originates directly from the protruding part of the coastline, but also from updrift sources. As coastline perturbations diffuse over time, sediment movement patterns gradually converge toward those of an undisturbed coast. At locations with oblique wave incidence this evolution manifests itself with predominant downdrift dispersal and updrift trapping of sediment from adjacent beaches. The successful application of our Lagrangian approach to this multi-year evolution demonstrates the potential of sediment particle tracking for understanding more complex coastal environments. Increased understanding of sediment pathways enhances our ability to predict and communicate coastal response to interventions, supporting more effective management strategies.

Discriminative fault diagnosis transfer learning network under joint mechanism

Dynamic culture system advances the applications of breast cancer organoids for precision medicine

Abstract Tumor organoid-based drug sensitivity prediction is a new approach for precision medicine, which has wide applications in cancer treatment and attracts increasing attention. In the field of breast cancer, conventional organoid culture methods often require more than three weeks of culture period. The culture time greatly limits the further extension of the application scenarios of breast cancer organoids. We developed a fluid system that builds on the conventional organoid “dome” culture method, which continuously and stably supplies the nutrients for the growth of breast cancer organoids. We demonstrated that this is an effective optimization method, which can shorten the culture period of breast cancer organoids without significant changes in histological characteristics and drug sensitivity features.

Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice

The COVID-19 pandemic and clinical characteristics of colorectal cancer: a multicenter retrospective study

The trading decision model of joint power market contain frequency/regulation/reserve

Association between TyG index with obesity indicators and coronary heart disease: a cohort study

Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection

Abstract The alpha-Gal syndrome (AGS) evolved as a catastrophic selection associated with anti-α-Gal IgM/IgG protective response against pathogen infection and tick-borne food allergy caused by IgE-type antibodies against this glycan present in glycoproteins and glycolipids from mammalian meat and derived products. The immune response to α-Gal is modulated by tick salivary proteins with and without α-Gal modifications in combination with tick saliva non-protein fraction. Herein, we characterized the role of tick salivary proteins, metalloprotease and allergen-like p23 in AGS and protection against tuberculosis in the AGS zebrafish animal model. Metalloprotease and p23 are involved in allergic reactions after mammalian meat consumption through upregulation of pro-inflammatory protein-coding genes prkdc, tlr2, tnfα and il1b. Challenge with Mycobacterium marinum activated Th1-mediated immune protective response with reduced pathogen infection, ameliorating Th2-associated allergic reactions associated with AGS. These results highlight molecular mechanisms modulated by tick proteins in response to α-Gal and provide insights to reduce AGS impact on human health.