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A bi-level optimization strategy of electricity-hydrogen-carbon integrated energy system considering photovoltaic and wind power uncertainty and demand response
Psychometric properties of the Arabic version of the Young Schema Questionnaire Short Form-Version 3 (YSQ-S3)
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons
Association between lifestyle risk factors and mortality in the Mexico City prospective study
Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis
Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons
FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells
Galectin 9 rescues the inducibility of IL-10 expression in regulatory B cells of patients with food allergy
Quantum key distribution implemented with d-level time-bin entangled photons
AbstractHigh-dimensional photon states (qudits) are pivotal to enhance the information capacity, noise robustness, and data rates of quantum communications. Time-bin entangled qudits are promising candidates for implementing high-dimensional quantum communications over optical fiber networks with processing rates approaching those of classical telecommunications. However, their use is hindered by phase instability, timing inaccuracy, and low scalability of interferometric schemes needed for time-bin processing. As well, increasing the number of time bins per photon state typically requires decreasing the repetition rate of the system, affecting in turn the effective qudit rates. Here, we demonstrate a fiber-pigtailed, integrated photonic platform enabling the generation and processing of picosecond-spaced time-bin entangled qudits in the telecommunication C band via an on-chip interferometry system. We experimentally demonstrate the Bennett-Brassard-Mermin 1992 quantum key distribution protocol with time-bin entangled qudits and extend it over a 60 km-long optical fiber link, by showing dimensionality scaling without sacrificing the repetition rate. Our approach enables the manipulation of time-bin entangled qudits at processing speeds typical of standard telecommunications (10 s of GHz) with high quantum information capacity per single frequency channel, representing an important step towards an efficient implementation of high-data rate quantum communications in standard, multi-user optical fiber networks.
The effect of PEO/NaCl dual porogens in the fabrication of porous PCL membranes via a solid-state blending approach
The presence of pleural effusion is an independent prognostic factor in patients with malignant pleural mesothelioma
A higher order PUF complex is central to regulation of C. elegans germline stem cells
AbstractPUF RNA-binding proteins are broadly conserved stem cell regulators. Nematode PUF proteins maintain germline stem cells (GSCs) and, with key partner proteins, repress differentiation mRNAs, including gld-1. Here we report that PUF protein FBF-2 and its partner LST-1 form a ternary complex that represses gld-1 via a pair of adjacent FBF binding elements (FBEs) in its 3′UTR. One LST-1 molecule links two FBF-2 molecules via motifs in the LST-1 intrinsically-disordered region; the gld-1 FBE pair includes a well-established ‘canonical’ FBE and a newly-identified noncanonical FBE. Remarkably, this FBE pair drives both full RNA repression in GSCs and full RNA activation upon differentiation. Discoveries of the LST-1–FBF-2 ternary complex, the gld-1 adjacent FBEs, and their in vivo significance predict an expanded regulatory repertoire of different assemblies of PUF-partner-RNA higher order complexes in nematode GSCs. This also suggests analogous PUF controls may await discovery in other biological contexts and organisms.
Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET
Vitality insights of fish escaping from a sorting grid installed on a bottom trawl net
Abstract Sorting grids to exclude the juveniles of species targeted by bottom trawl fisheries from the catch are among the most promising solutions to reduce discards. We tested a two-sections Juveniles’ Sorting Grid (JSG) in a Mediterranean fisheries restricted area. First, we provided information on the vitality of individuals escaping from the JSG bars during towing, by analysing underwater footage. Then, we evaluated the catch performance of the JSG-equipped trawl compared to a standard trawl by analysing both the full species community in the catches and the main commercial species. The probability for individuals to be alive while escaping from JSG was always higher than 65% (on average), with some species (e.g. red mullet, gurnards, 91–99% on average) showing significantly higher probability than others (e.g. European hake, crustaceans, 65–82% on average). The installation of a JSG in the trawl net did not change the overall catch composition in the codend, although significant differences were observed at the single species level. The JSG was effective at reducing undersized individuals of European hake, although a loss of legal-sized individuals was observed due to escapement. A significantly lower retention of the JSG-equipped trawl was also observed for other commercial species, such as deep-water rose shrimp and broadtail shortfin squid.
Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial
AbstractGT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We conducted a first-in-human phase 1b study dose escalation trial of GT103 in refractory non-small cell lung cancer to assess the safety of GT103 (NCT04314089). Dose escalation was performed using a “3 + 3” schema with primary objectives of determining safety, tolerability, PK profile and maximum tolerated dose (MTD) of GT103. Secondary objectives included describing objective response rate, progression-free survival and overall survival. Dose escalation cohorts included GT103 given intravenously at 0.3, 1, 3, 10, and 15 mg/kg every 3 weeks, and 10 mg/kg every 2 weeks. Thirty one patients were enrolled across 3 institutions. Two dose-limiting adverse events were reported: grade 3 acute kidney injury (0.3 mg/kg) and grade 2 colitis (1 mg/kg). No dose-limiting toxicities were noted at the highest dose levels and the MTD was not reached. No objective responses were seen. Stable disease occurred in 9 patients (29%) and the median overall survival was 25.7 weeks (95% confidence interval [CI], 19.1–30.6). Pharmacokinetic analysis confirmed an estimated half life of 6.5 days. The recommended phase 2 dose of GT103 was 10 mg/kg every 3 weeks, however further dose optimization is needed given the absence of an MTD. The study achieved its primary objective of demonstrating safety and tolerability of GT103 in refractory NSCLC.
CoGraphNet for enhanced text classification using word-sentence heterogeneous graph representations and improved interpretability
Influence of phonon anharmonicity on Raman spectra of Cu2ZnSn(S,Se)4 polycrystalline thin films through computational study
Structural insights into the regulation of monomeric and dimeric apelin receptor
AbstractThe apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer during activation remains poorly understood. In this study, we present the structures of the APJR dimer and monomer complexed with its endogenous ligand apelin-13. In the dimeric structure, apelin-13 binds exclusively to one protomer that is coupled with Gi proteins, revealing a distinct ligand-binding behavior within APJR homodimers. Furthermore, binding of an antagonistic antibody induces a more compact dimerization by engaging both protomers. Notably, structural analyses of the APJR dimer complexed with an agonistic antibody, with or without Gi proteins, suggest that G protein coupling may promote the dissociation of the APJR dimer during activation. These findings underscore the intricate interplay between ligands, dimerization, and G protein coupling in regulating APJR signaling pathways.