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Personality traits of women with hereditary risk for breast/ovarian cancer versus obstetric history and cancer preventive behaviors
Abstract The aim of the study is to analyze the relationship between personality traits of women with hereditary predisposition to breast/ovarian cancer and their obstetric history and cancer-preventive behaviors. A total of 357 women, participants of ‘The National Program for Families With Genetic/Familial High Risk for Cancer’, were included in the study. The Neo Five-Factor Inventory (NEO-FFI) and a standardized original questionnaire designed for the purpose of the study were used. Breast ultrasound examination at a younger age was associated with Extraversion. Openness to Experience was linked with lower number of children, more frequent use of hormonal contraceptives, and younger age at first breast ultrasound examination. Women with higher Agreeableness scores were less likely to use contraceptives and underwent their first breast ultrasound later in life. Conscientiousness was associated with more frequent use of hormonal contraceptives and younger age at first breast ultrasound examination. Women at increased risk for developing breast/ovarian cancer who used hormonal contraceptives underwent breast ultrasound examinations earlier in life, while those who had breastfed their children chose to have their first mammogram earlier in life. Personality traits affect health-related behaviors and should be taken into account when designing theoretical models as well as interventions regarding health habits.
Protective effect of Panax ginseng extract on cisplatin-induced AKI via downregulating cell death associated genes
Unveiling the omics tapestry of B-acute lymphoblastic leukemia: bridging genomics, metabolomics, and immunomics
Imaging cells and nanoparticles using modulated optically computed phase microscopy
$$\hbox {H}_2$$-roaming dynamics in the formation of $$\hbox {H}_{3}^{+}$$ following two-photon double ionization of ethanol and aminoethanol
Abstract Roaming reactions involving a neutral fragment of a molecule that transiently wanders around another fragment before forming a new bond are intriguing and peculiar pathways for molecular rearrangement. Such reactions can occur for example upon double ionization of small organic molecules, and have recently sparked much scientific interest. We have studied the dynamics of the $$\hbox {H}_2$$ -roaming reaction leading to the formation of $$\hbox {H}_3^+$$ after two-photon double ionization of ethanol and 2-aminoethanol, using an XUV-UV pump-probe scheme. For ethanol, we find dynamics similar to previous studies employing different pump-probe schemes, indicating the independence of the observed dynamics from the method of ionization and the photon energy of the disruptive probe pulse. Surprisingly, we do not observe a kinetic isotope effect in ethanol- $$\hbox {D}_6$$ , in contrast to previous experiments on methanol where such an effect was observed. This distinction indicates fundamental differences in the energetics of the reaction pathways as compared to the methanol molecule. The larger number of possible roaming pathways compared to methanol complicates the analysis considerably. In contrast to previous studies, we additionally analyze a broad range of dissociative ionization products, which feature distinct dynamics from that of $$\hbox {H}_{3}^{+}$$ and allow initial insight into the action of the disruptive UV-probe pulse.
Enhancing food and nutrition security in Himalayan foothills with neglected and underutilized millets
Investigation into the PSD characteristics of internally unstable soils susceptible to suffosion
Structural, morphological and biological assessment of magnetic hydroxyapatite with superior hyperthermia potential for orthopedic applications
Abstract Hydroxyapatite (HA) is an important constituent of natural bone. The properties of HA can be enhanced with the help of various ionic substitutions in the crystal lattice of HA. Iron (Fe) is a vital element present in bones and teeth. In this study, iron-doped HA was synthesized using a refluxing-based sol-gel route with varying concentrations of iron (1–9 M%). Samples were analyzed using an X-ray diffractometer (XRD), UV–Vis Spectrophotometer, Fourier-transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) and Scanning Electron Microscope (SEM). The biological assessment was carried out by hemolytic assay, anti-bacterial activity and in-vitro biocompatibility. XRD data confirmed the evolution of the hexagonal HA crystal structure with the reduction in the crystallinity and the crystallite size. All the characteristic bands were confirmed using FT-IR which also further proved the existence of A-type carbonated apatite. The UV–Vis spectra confirmed the reduction in the band gap energies owing to the substitution of iron. The SEM results showed a change in the shape of the samples with increasing iron concentration. The magnetic behavior of samples also altered from diamagnetic to ferromagnetic behavior due to the doping of iron with enhanced heating efficiency. All the samples were found to be hemocompatible. The antibacterial efficacy was found to be higher for E. coli (gram-negative) bacteria compared to S. aureus (gram-positive) bacteria. Moreover, the superior cell viability of MG-63 (osteoblast-like) cells was observed in Fe-doped HA, attributed to MTT assay which revealed the enhanced cell viability of osteoblast-like cells in the Fe-doped HA. These results strongly emphasize the potential of the developed samples for bone regeneration applications.
Inaudible airborne ultrasound affects emotional states in the olfactory bulbectomized rat depression model
Effects of different water and fertilizer treatments on the matrix properties and plant growth of tailings waste
Suicidality, resilience and burnout in a population of oncology nurses
Failure modes and interaction mechanisms of tunnel under active landslide conditions
Knowledge, attitude, and practice of aesthetic medicine practitioners towards laser and/or light therapy for hypertrophic scars
Optimizing polycrystalline diamond compact bit selection and drilling parameters for deviated wells in the Majnoon Field, Iraq
Genomic analysis of three medieval parchments from German monasteries
Abstract In the last two decades there has been growing interest in the analysis of ancient DNA obtained from the parchment used in historic documents. The genetic insight that this data provides makes collections of historic documents an invaluable source for studying the development and spread of historical livestock populations. Additionally, the biological data may provide new information for the historical analysis that could be used to determine the provenance as well as the authenticity of these documents. In this study, we extracted DNA from three medieval parchments that were written in German monasteries in the twelfth century. The source animal of the parchments could be identified as cattle and we compared their genome sequences with those of modern populations that are part of the 1000 Bull Genomes Project. The three animals were found to carry mtDNA haplogroup T3 and show a closer genetic relationship to other historic animals than to modern breeds. We further identified 39 haplotypes and 132 SNPs variants, which are rare ( $$<0.1$$ < 0.1 ) or even non-existent in modern breeds. Finally, the genetic distances between the parchment samples show a putative association with the dates when the documents were written, indicating the usefulness of genetic analysis for provenance research.
Enhancing power system stability using a TCSC-PIDF controller with innovative multiobjective function and hybrid optimisation logic
Prescribed time control of position and force tracking for dualarm robots with output error constraints
Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer
Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury
Abstract Spinal cord injury (SCI) is a significant cause of lifelong disability, with no available disease-modifying treatments to promote neuroprotection and axon regeneration after injury. Photobiomodulation (PBM) is a promising therapy which has proven effective at restoring lost function after SCI in pre-clinical models. However, the precise mechanism of action is yet to be determined. Here, we used an in-vivo model of SCI in adult rats that received daily PBM (660 nm, 24 mW/cm2, 1 min) and at three days post-injury, the injured spinal cord segment was harvested and subjected to whole transcriptome sequencing and subsequent pathway analysis (generally applicable gene-set enrichment (GAGE)). Pathway analysis demonstrated 1275 differentially expressed genes (DEGs) after PBM treatment, of which 397 were upregulated and 878 were downregulated. Key pathways were significantly enriched, including 8.6-fold enrichment of “neuron projection morphogenesis” (adjusted p = 8.10 × 10− 14), with upregulation of Notch3, Slit1/Robo2 and Sema3g pathways. Ribosomal and oxidative phosphorylation pathways and NADH dehydrogenase were downregulated, and there was upregulation of ATP-dependent activity, cAMP and calcium signalling pathways. Key genes in apoptotic pathways were downregulated, as were S100 and cyclo-oxygenase components. Together, our study supports the favourable effects of PBM in promoting neuroregeneration and suppressing apoptosis after neurological injury. Further findings from pathway analysis suggest that downregulation of metabolism-associated pathways is a mechanism by which acute post-injury mitochondrial dysfunction may be averted by PBM therapy.