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Neural correlates of altered reward-driven attention in chronic pain and opioid use
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27
Associations between daily composition of 24 h physical behavior with affective states and working memory
Abstract The daily association between 24-hour physical behavior compositions (moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), standing, sedentary, and sleep) and psychological outcomes—such as momentary affective state assessments and working memory—remains understudied. We investigated whether the daily 24-hour compositions, particularly MVPA and SB considering the remaining behaviors, are associated with affective states and working memory. We conducted an ambulatory assessment study with 199 university employees. Physical behaviors were measured continuously via thigh-worn accelerometers throughout the day. Affective states (i.e., valence, energetic arousal, and calmness) and working memory performance (i.e., numeric updating task) were captured up to six times a day via electronic diaries and tasks on a smartphone. We conducted Bayesian multilevel compositional data analysis to analyze within-person, and between-person associations of 24-hour physical behavior composition with affective states, and working memory. Aggregated same-day outcomes were used for main analyses to capture concurrent associations, and next-day outcomes were used for exploratory analyses to capture prospective associations. Concurrent analyses showed that higher moderate-to-vigorous physical activity relative to the remaining physical behaviors was associated with 2.49 [95%CI 1.00, 4.06] higher valence and 3.65 [95%CI 2.11, 5.28] higher energetic arousal (but not calmness) ratings at the within-person, but not at the between-person level. Sedentary behavior relative to the remaining physical behaviors was not associated with any affective states. Spending more time in moderate-to-vigorous physical activity, followed by light physical activity, and standing, each at the expense of the other behaviors was associated with higher affective state ratings on the same day (between-person: ≥1.29 [0.19, 2.51] higher valence, 1.23 [0.04, 2.40] higher calmness; within-person: ≥0.62 [0.04, 1.22] higher valence, ≥ 1.10 [0.63, 1.58] higher energetic arousal, ≥ 0.95 [0.18, 1.74] higher calmness). The 24-hour physical behavior composition was not associated with working memory. Findings underline the importance of the 24-hour composition of physical behavior for mental health, by demonstrating significant concurrent associations with affective states. Even small reallocations of behaviors may positively influence affective states, providing valuable insights for the development of future interventions.
Audio long read: Do smartphones and social media really harm teens’ mental health?
The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment
Abstract Prior to the discovery of bat influenza A virus (IAV) subtypes H17N10 and H18N11, all IAVs were thought to bind sialic acid residues via hemagglutinin (HA) to mediate attachment and subsequent viral entry. However, H17 and H18 engage a proteinaceous receptor: the major histocompatibility complex class II (MHCII). The mechanistic details of this hitherto unknown protein-mediated entry are not understood. Given that conventional IAVs rely on multivalent binding to sialylated glycans, we hypothesized that bat HA similarly interacts with multiple MHCII molecules. Using photoactivated localization microscopy (PALM) on fixed and live cells, we demonstrate that bat IAV particles attach to pre-existing MHCII clusters and induce a further increase in cluster size upon binding. To measure the impact of viral attachment on the dynamics of MHCII, we employ an “inverse attachment” approach, immobilizing viral particles on coverslips before seeding live MHCII-expressing cells on top. Single-molecule tracking reveals that the mobility of MHCII is indeed slowed down in viral proximity leading to a local enrichment of MHCII molecules beneath the viral particle. These findings suggest that viral attachment induces MHCII clustering, a process similar to the MHCII dynamics observed during the formation of an immunological synapse.
A prediction model for moderate to severe pain in primary hepatic carcinoma after chemotherapy: a multi-center prospective case‒control study
My ‘woke DEI’ grant has been flagged for scrutiny. Where do I go from here?
Zinc agronomic biofortification in wheat and its drivers: a global meta-analysis
Impact of clinical factors on the diagnostic performance of diffuse optical spectroscopic imaging for breast cancer
Daily briefing: Fibromyalgia eases after doses of gut microbes
Comparative efficacy of modified Shiraki procedure and pedicled Island preputial flap in the treatment of severe concealed penis in children
Author Correction: Experimental and theoretical investigation of cyclohexanone derivative (CHD) as a corrosion inhibitor for mild steel in 1 M HCl
Hundreds more NSF grants terminated after agency director resigns
Atmospheric carbon dioxide concentration as fuel gauge
Abstract Climate change skeptics like to point to the high atmospheric carbon dioxide concentration in paleo records as “ proof ” of the exaggeration of the climate change agenda. Instead of debunking these arguments, the present paper represents a thought experiment that considers the atmospheric carbon dioxide concentration in the past as a proxy for fossil fuel reserves and interprets the contemporary rise in carbon dioxide concentration as a fuel gauge to estimate the exhaustion of the remaining fossil fuel reserves under different energy consumption scenarios. The resulting conclusion is that the dangers of exhausting the remaining fossil fuel resources are likely on par with the anticipated adverse effects of climate change and should convince even climate change skeptics that the transition to non-fossil energy sources is inevitable and urgent since the remaining fossil fuel reserves will be likely exhausted in less than a century. The presented analysis goes further than the currently adopted “ net-zero ” ambitions. It demonstrates that there is no room for compromise and the transition has to be “ true-zero ” use of fossil fuels. Accounting gimmicks like carbon capture and sequestration or carbon trading are just as unsustainable as the continued reliance on fossil fuels.
Translational immune and metabolic markers of aging in dogs
Intelligent and automatic irrigation system based on internet of things using fuzzy control technology
Effect of optical technical of guiding emmetropization lenses on myopia prevention in children without myopia
Integrated bioinformatics analysis screened the key genes and pathways of idiopathic pulmonary fibrosis
Raman spectroscopic characterization of crater walls formed upon single-shot high-energy femtosecond laser irradiation of dimethacrylate polymer doped with plasmonic gold nanorods
Abstract The bonding configuration of the crater walls formed in urethane dimethacrylate-based polymer doped with plasmonic gold nanorods upon irradiation with a single-shot high-energy femtosecond laser pulse has been studied by Raman spectroscopy. New Raman bands were detected in the 2000–2500 cm-1 region of the Raman spectrum the intensities of which showed strong dependence on the concentration of the plasmonic nanoparticles and the energy of the laser pulse. Based on model calculations of the Raman frequencies of the polymer these peaks were attributed to carbon-deuterium and nitrogen-deuterium vibrations. Their appearance might indicate the occurrence of nuclear reactions in the polymer excited by the ultra-strong laser field amplified by the plasmonic nanoparticles.