Browse Articles

In situ and real-time ultrafast spectroscopy of photoinduced reactions in perovskite nanomaterials

Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron

Single-Crystal Metal–Organic and Covalent Organic Framework Hybrids Enable Efficient Photoelectrochemical CO₂ Reduction to Ethanol

Plasmon mode engineering with electrons on helium

TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study

Square-Planar Tetranuclear Cluster-Based High-Symmetry Coordination Metal–Organic Polymers for Efficient Electrochemical Nitrate Reduction to Ammonia

An RNA transmethylation pathway governs kidney nephrogenic potential

Performance-Enhancing Asymmetric Catalysis Driven by Achiral Counterion Design

Dietary advanced glycation end-products promote food allergy by disrupting intestinal barrier and enhancing Th2 immunity

An optimized disease resistance gene cloning workflow for wheat

“Two-in-One” DPP Building Blocks for Ambipolar Conjugated Polymers in Flexible Transistors

Ubiquitin Azapeptide Esters as Next-Generation Activity-Based Probes for Cysteine Enzymes in the Ubiquitin Signal Pathway

Elevated heterotrophic activity in Guaymas Basin hydrothermal plumes influences deep-sea carbon cycling

A single spin in hexagonal boron nitride for vectorial quantum magnetometry

Abstract Quantum sensing based on solid-state spin defects provides a uniquely versatile platform for nanoscale magnetometry under diverse environmental conditions. Operation of most sensors used to-date is based on projective measurement along a single axis combined with computational extrapolation. Here, we show that an individually addressable carbon-related spin defect in hexagonal boron nitride is a multi-axis nanoscale sensor with large dynamic range. For this spin-1 system, we demonstrate how its spin-dependent photodynamics give rise to three optically detected spin resonances that show up to 90% contrast and are not quenched under off-axis magnetic field exceeding 100 mT, enabling $$\mu \,{{\rm{T}}}/{{{\rm{Hz}}}^{-1/2}}$$ μ T / Hz − 1 / 2 sensitivity. Finally, we show how this system can be used to unambiguously determine the three components of a target magnetic field via the use of two bias fields. Alongside these features, the room-temperature operation and the nanometer-scale proximity enabled by the van der Waals host material further consolidate this system as a promising quantum sensing platform.

Relaxation-Based In Vivo Discrimination of Oxidized and Reduced States of a Redox-Switchable ¹⁹F MRI Probe

Proactive measures help shape the EU candidate list of substances of very high concern

Supramolecular Copolymerization of Glycopeptide Amphiphiles and Amyloid Peptides Improves Neuron Survival

RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

Abstract Defective DNA repair and metabolic rewiring are highly intertwined in promoting the development and progression of cancer. However, the molecular players at their interface remain poorly understood. Here we show that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramming in lung cancer. We demonstrate that RNF20, which catalyzes monoubiquitylation of histone H2B (H2Bub1), controls Rbx1 expression and thereby the activity of the VHL ubiquitin ligase complex and HIF1α levels. Ablation of a single Rnf20 allele significantly increases the incidence of lung tumors in mice. Mechanistically, Rnf20 haploinsufficiency results in inadequate tumor suppression via the Rnf20-H2Bub1-p53 axis and induces DNA damage, cell growth, epithelial-mesenchymal transition (EMT), and metabolic rewiring through HIF1α-mediated RNA polymerase II promoter-proximal pause release, which is independent of H2Bub1. Importantly, decreased RNF20 levels correlate with increased expression of HIF1α and its target genes, suggesting HIF1α inhibition as a promising therapeutic approach for lung cancer patients with reduced RNF20 activity.

Dual-Channel Phosphorescence Ratiometry and Phosphorescence Lifetime Imaging of Mitochondria-Specific Methionine Sulfoxide Reductase Activity

Direct synthesis of N-trifluoromethyl amides via photocatalytic trifluoromethylamidation