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Use of PCR cycle threshold values for toxins A and B quantification in Clostridioides difficile infections
Spin Manipulation Engineering of Photodynamic Intermediates: Magnetic Amplification of Oxyradicals Generation for Enhanced Antitumor Phototherapeutic Efficacy
LGLoc as a new language model-driven graph neural network for mRNA localization
Synthesis, anticancer evaluation, and electrochemical investigation of new chiral pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides
Precise <i>de novo</i> Design Principle of Antifreeze Peptides
Serum LncRNA PSMB8-AS1 as a novel biomarker for predicting acute coronary syndrome
Simple and Scalable Introduction of Single-Atom Mn on RuO<sub>2</sub> Electrocatalysts for Oxygen Evolution Reaction with Long-Term Activity and Stability
Temporal context-guided memory capabilities in rodents
Abstract Environmental contexts serve as powerful cues for episodic memory, allowing humans to recall events tied to specific settings. While rats can learn context-specific associations and temporal order, their ability to manage multiple contexts and rapidly adapt to changes in context remains unclear. This study investigated whether rats could order objects across two distinct contexts. Eight Lister Hooded rats were trained in a dual-context maze, where each context contained a pair of objects. In each trial, rats entered the maze, selected an object, and then re-entered either the same or a different context to complete the trial in the correct temporal order. Six rats successfully learned object order within a single context, but only two reached criterion in the more complex two-context condition. Group error analyses revealed a partial reliance on a procedural learning strategy and a tendency to favour one context, where prior location influenced object selection in subsequent trials. While two rats successfully adapted to the two-context condition beyond these simple strategies, most struggled with context switching, exhibiting perseveration difficulties—a trait also observed in some humans. These findings highlight the evolutionary foundations of context-guided memory and reveal remarkable individual variability in the ability to flexibly navigate multiple contexts.
Unraveling the mechanisms of irAEs in endometrial cancer immunotherapy: insights from FAERS and scRNA-seq data
Prevalence of menstrual pain and symptoms and their association with age and BMI among Japanese female app users
Abstract Menstruation plays a crucial role in women’s health, with age and BMI potentially influencing menstrual pain and associated symptoms. This cross-sectional study analyzed data from Japanese female Sofy app users aged 12–51 years, collected between March 4, 2021, and August 17, 2023. After excluding duplicate and incomplete responses, as well as participants using contraceptives or painkillers, a total of 32,556 valid responses were included. Among the participants, 66.83% reported experiencing menstrual pain, with 28.33% describing it as mild, 25.13% as moderate, and 13.31% as severe. The average number of symptoms reported was 3.36, including 2.43 physical and 0.82 emotional symptoms. Abdominal pain and depression were the most common physical and emotional symptoms, respectively. Menstrual pain and the number of symptoms exhibited an inverted U-shaped relationship with age, peaking slightly earlier in life, and a U-shaped relationship with BMI. Participants in the normal BMI range reported the lowest prevalence of menstrual pain, while those who were underweight had the highest prevalence. Generalized Additive Models (GAM) revealed significant interactions between age and BMI for both menstrual pain and the number of symptoms (p < 0.0001). These findings revealed the age-related inverted U-shape and BMI-related U-shape patterns across all outcomes. Menstrual pain prevalence peaked around the mid-twenties, and symptoms decreased as BMI approached the normal range. The findings provide valuable insights into identifying high-risk groups and informing the development of targeted interventions to improve women’s health.
Identification of metabolic pathways and serum biomarkers in diabetic cardiomyopathy using untargeted metabolomics
Habitat use and growth strategies of amphidromous fish “ayu” throughout a river system
Rock image classification based on improved EfficientNet
Drug repurposing targeting COVID-19 3CL protease using molecular docking and machine learning regression approaches
Federated stochastic gradient averaging ring homomorphism based learning for secure data aggregation in WSN
Enhancing cognitive and physical performance in older adults through wearable sensor-based interactive cognitive-motor training: a randomized clinical trial
Bio-synthesis of bacterial cellulose from ramie textile waste for high-efficiency Cu(II) adsorption
Abstract The current study aims at the high-value utilization of ramie textile waste and explores a bio-synthetic pathway to convert waste ramie fibers into bacterial cellulose (BC). Ramie fibers were treated with commercial cellulase (C2730) and the hydrolysate was used as a base medium (RFH) for BC synthesis by fermentation. The enzymatic hydrolysis parameters were optimized by response surface methodology, yielding an optimal temperature of 40 °C, 64 h, and an enzyme dosage of 5.7%. Under these optimized conditions, the resultant yield of reducing sugars was 31.24 ± 0.37 g/L. And then the Novacetimonas hansenii HX1 strain isolated from kombucha was used for fermentation production of BC. The study found that adding yeast extract into RFH can significantly increase BC production, and 7.2 g/L BC can be produced within 7 days. The physical and chemical properties of BC were then analyzed, including Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Thermogravimetric analysis (TGA), confirming its type I α cellulose structure and good thermal stability. In particular, BC shows efficient adsorption capacity for Cu(II) ions in aqueous solution, with the highest adsorption efficiency reaching 95.62%. This research not only provides a new way to recycle textile waste, but also lays the foundation for the application of BC in the field of environmental remediation.