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Metal–Organic Framework as a Bioorthogonal Catalyst for Gene Editing

Enantiodivergent Construction of <i>Oxa</i> -Quaternary Carbon Centers via Desymmetrization Based on Palladium/Chiral Norbornene Cooperative Catalysis

Exploring the therapeutic potential of tamoxifen conjugated ZnO nanoparticles for cancer treatment

Synthetic Chimeric Antigen Lysosome-Associated Receptor Redirects Targeted Protein to Degradation

Pressurized Gas-Driven Elemental Redistribution Enables Ultrastable PtNi Catalysts for Heavy-Duty Vehicles

Prior clinically diagnosed human papillomavirus infection and risk of esophageal cancer

Confinement of Americium in a Silver Nanocluster Reduces its Bond Covalency

Technological and design features of dies for the parting of long products by shearing with differentiated clamping

A Modular Post-Polymerization Modification Route to Aminated Polybutadienes for Electrochemical CO ₂ Valorization

Protective efficacy of a single-domain ASP-based vaccine against the bovine intestinal nematode Cooperia oncophora

Deuterated Water Accelerates Phase-Separated Droplet Formation and Enables Directional Motion

Dislocation density–based constitutive modeling and experimental validation of cold-rolled AA1050 aluminum with a techno-economic assessment for lithium-ion battery applications

Biomolecular Condensates Act as Distinct Solvation Environments That Reshape Amino Acid p <i>K</i> _a Values

The course and trajectories of quality of life among post-COVID-19 patients in the HUS long covid cohort study

Abstract Patients with post-COVID condition (PCC) frequently report reduced quality of life (QoL). This study assessed QoL and health-related QoL (HRQoL) with trajectories within a prospective PCC cohort. The study included adult patients at a PCC clinic. Outcomes were collected at 0, 3, 6, and 12 months. The primary outcome was QoL by Visual Analogue Scale (VAS 0–10). Secondary outcomes included QoL by EUROHIS-QOL-8 and HRQoL by 15D, and patients’ symptom perceptions by Somatic Symptom Disorder - B Criteria Scale (SSD-12). Linear mixed models analyzed temporal changes, and trajectory analysis modeled recovery patterns. At baseline, 442 patients participated, with 305 (69.0%) providing follow-up data. Most patients (92.7%) were non-hospitalized. Trajectory analysis of EUROHIS-QOL-8 identified two recovering trajectories (73.8%) and a stable group (26.2%). Stable trajectories were associated with more comorbidities and higher levels of worry-inducing symptom perceptions (mean SSD-12 score 26 out of 48), whereas marked recovery was linked to being employed and having lower SSD-12 (10–13). Mean QoL improved over 12 months from 5.2 to 6.5 on the 0–10 VAS scale and from 3.1 to 3.5 on the EUROHIS-QOL-8 scale of 1–5. HRQoL by 15D increased from 0.76 to 0.80 (scale 0–1). In conclusion, patients with comorbidities and distressing illness beliefs are the most vulnerable group in rehabilitation and require specific attention.

5′-Palmitate Lipid and Internal LNA-Piperidyl Triesters Enhance the RNA Affinity and Activity of Splice-Switching Oligonucleotides

Interpretable machine learning for preoperative prediction of ground-glass nodules invasiveness in lung adenocarcinoma: a multicenter study

Deciphering Site-Specific Kinetics on Shaped Pd Nanocrystals via Single-Particle Electrocatalysis

Gingival phenotype modification using collagen matrix versus acellular allogenic dermal matrix: A comparative preclinical study

Controlled Synthesis of Topologically Diverse Polyrotaxanes by Ring-Opening Polymerization of Mechanically Interlocked Monomers

Achieving &gt;99.9% Faradaic Efficiency for Complete Ethanol Electrooxidation over a Co–PdZn Heterointerface