Browse Articles

Factors influencing the real-world effectiveness of benralizumab in uncontrolled asthma

Promising results with zongertinib in advanced-stage HER2-mutant NSCLC

Mechanically flexible mid-wave infrared imagers using black phosphorus ink films

Abstract The mid-wave infrared (MWIR) spectral range (λ = 3–8 μm) enables important sensing and imaging applications, including non-invasive bioimaging, night vision, and autonomous navigation. Commercial MWIR photodetectors are limited to rigid imagers based on heteroepitaxial materials. There is an emerging need for mechanically flexible MWIR imagers to broaden their functionality and practicality. Recently, photodetectors using van der Waals (vdW) black phosphorus (BP) flakes have demonstrated highly sensitive room-temperature photodetection. Additionally, vdW materials are solution-processable, facilitating scalable processing and flexible device fabrication. In this work, we present flexible MWIR imagers consisting of photodiodes fabricated on thin plastic substrates using BP ink films. We demonstrate mechanically robust responsivity up to 2.5-mm bending radii and after 5000 bending cycles. Leveraging this flexibility, we achieve full-azimuthal imaging, detecting directional light sources with precision. These results establish a scalable approach for large-area, conformable MWIR imaging and pave the way for integration with flexible electronics.

Noncanonical short-latency auditory pathway directly activates deep cortical layers

Front Cover: AI.zymes – A Modular Platform for Evolutionary Enzyme Design (Angew. Chem. Int. Ed. 27/2025)

Scalable Main Group Mechanocatalytic CO ₂ Valorisation to Cyclocarbonate Species

Abstract Over the past two decades, main group elements have gained attention as promising substitutes for precious metals in catalytic processes. Additionally, mechanochemistry is emerging as a field with the potential to promote catalytic reactions under mild conditions. Herein, we report a scalable, main‐group mechanocatalytic synthesis of cyclic carbonates from both solid and liquid epoxides, using CO₂ as a renewable feedstock under mild conditions with a gallium aminotrisphenolate catalyst. Unlike solution‐based methods that generally require high temperatures and/or high CO₂ pressures, this mechanocatalytic process operates at just 1 bar and room temperature. The developed mechanochemical method affords the targeted compounds in high yields while also enabling efficient transformation of multi‐terminal epoxides and avoiding the conversion losses typically observed in solution. Furthermore, this scalable method outperforms solution‐based approaches across all green metrics, setting a new benchmark for environmentally friendly synthesis.

Direct Synthesis of Poly(adipate)Esters via Catalytic Isomerizing Dual Hydroesterificative Polymerization of 1,3‐Butadiene

Abstract Aliphatic polyesters, such as poly(adipate)esters, are attracting substantial attention as sustainable materials due to their degradability, recyclability, and versatility in various applications. However, the conventional production of poly(adipate)esters relies on energy‐intensive processes and petroleum‐derived adipic acid (AA), whose synthesis poses environmental concerns, including nitrous oxide emissions. Herein, we introduce a novel Pd‐catalyzed isomerizing dual hydroesterificative polymerization (IDHP) strategy for direct poly(adipate)ester synthesis from readily available feedstocks of 1,3‐butadiene, diols, and carbon monoxide. Key to success lay in the utilization of an electron‐rich phosphine ligand with bulky steric hindrance, which efficiently facilitated linear‐selective isomerizing hydroesterification. Mechanistic investigations revealed that the isomerizing hydroesterificative polymerization exhibited remarkable efficiency in producing poly(adipate)esters. The resulting poly(adipate)esters possess a similar structure compared to those produced by traditional polycondensation. With abundant feedstocks and atom‐economy, this methodology provides a practical and eco‐friendly approach to the production of poly(adipate)esters with varied microstructures.

Spatial temporal trends and inequality in agricultural eco-efficiency under carbon constraints in China

Predictive value of asprosin combined with LAP for metabolic dysfunction associated steatotic liver disease in the physical examination population

A novel Compound-Pareto model with applications and reliability peaks above a random threshold value at risk analysis

LASSO regression-based nomogram for distinguishing nontuberculous mycobacterial pulmonary disease from pulmonary tuberculosis: a clinical risk prediction model

New equations to estimate 24-h urinary creatinine excretion

Self-perceived health control status and influencing factors in young and middle-aged peritoneal dialysis patients: a cross-sectional survey

Assessments of Anopheles arabiensis behaviour around bed nets using partial adhesive treatments

NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD

Next-generation KRAS-G12C inhibitor D3S-001 shows promise

Genomic landscape of virus-associated cancers

Abstract It has been estimated that 15%-20% of human cancers are attributable to infections, mostly by carcinogenic viruses. The incidence varies worldwide, with a majority affecting developing countries. Here, we conduct a comparative analysis of virus-positive and virus-negative tumors in nine cancers linked to five viruses. We observe a higher frequency of virus-positive tumors in males, with notable geographic differences in incidence. Our genomic analysis of 1971 tumors reveals a lower somatic burden, distinct mutation signatures, and driver gene mutations in virus-positive tumors. Compared to virus-negative cases, virus-positive cases have fewer mutations of TP53, CDKN2A, and deletions of 9p21.3/CDKN2A-CDKN1A while exhibiting more mutations in RNA helicases DDX3X and EIF4A1. Furthermore, an analysis of clinical trials of PD-(L)1 inhibitors suggests an association of virus-positivity with higher treatment response rate, particularly evident in gastric cancer and head and neck squamous cell carcinoma. Both cancer types also show evidence of increased CD8 + T cell infiltration and T cell receptor clonal selection in virus-positive tumors. These results illustrate the epidemiological, genetic, and therapeutic trends across virus-associated malignancies.

An intracranial dissection of human escape circuits

Metal Complexes Stimulating Immunogenic Pyroptosis as Burgeoning Antitumor Strategy

Abstract The exploration of antitumor agents with diverse action mechanisms has become an important focus in both fundamental research and clinical oncology, driven by the need for more effective cancer therapies. Metal complexes, with their versatile chemical, photophysical, and biological properties, represent an ideal class of therapeutic and diagnostic candidates for investigating novel antitumor mechanisms. Recent advances have underscored their unique ability to trigger diverse cell death pathways. Among these, pyroptosis, an inflammatory form of programmed cell death, has garnered substantial attention because of its intrinsic link to antitumor immunity. This minireview focuses on the cutting‐edge developments in antitumor metal complexes designed to induce pyroptosis and elucidates their pyroptosis‐stimulating mechanisms across chemo‐, photo‐, sono‐ and targeted therapeutic modalities. By dissecting the interplay among pyroptosis induction, biological processes, such as inflammasome activation and gasdermin cleavage, and subsequent immune reprogramming, we provide a thorough overview of the action mechanisms of metal complex‐based pyroptosis inducers. This understanding has inspired the rational development of novel anticancer metal complexes that can remodel the tumor microenvironment and synergize with immunotherapies.

Masahiko Yoshimura