Browse Articles

“Injectable ARVs will give me peace” women’s acceptability of injectable antiretroviral therapy in prevention of HIV vertical transmission in Uganda

Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair

Dynamic mechanical behavior and constitutive relationship of rubber fiber concrete after high temperature

Room Temperature Ring Opening of Benzene by Four-Electron Reduction and Carbonylation

A pilot study on LC–MS/MS quantification of remifentanil, etomidate, and rocuronium in maternal and fetal serum microsamples

Positron Emission Tomography (PET) Neuroimaging of the <i>Pink1-/-</i> Rat Parkinson Disease Model with the Norepinephrine Transporter (NET) Ligand [¹⁸F]NS12137

Evidence suggests that the neurotransmitter norepinephrine may play an important role in Parkinson disease (PD). The norepinephrine transporter (NET) regulates noradrenergic signaling and can serve as an index of noradrenergic innervation in neuroimaging studies. The Pink1-/- rat model, which exhibits many signs similar to PD, notably in the nonmotor domain, exhibits abnormal noradrenergic markers. Here, we sought to (1) implement reference region pharmacokinetic modeling of positron emission tomography (PET) imaging with the novel NET ligand [18F]NS12137, (2) validate the resulting indices of NET concentration, and (3) characterize NET in the Pink1-/- model. Long–Evans Pink1-/- male rats were imaged by PET with [18F]NS12137 at 9 and 11 months and compared with wild-type (WT) controls. An additional group of WT rats of both sexes were imaged with [18F]NS12137 PET after pretreatment with the specific and selective NET ligand nisoxetine. Binding in locus coeruleus (LC), thalamus (Thal), and prelimbic area (PrL), regions rich in NET, was analyzed by a two-tissue compartment reversible binding model using a cerebellar reference region. [18F]NS12137 binding exhibited moderate test–retest reproducibility in LC, Thal, and PrL. Nisoxetine blockade yielded substantial reductions of [18F]NS12137 binding in LC. Compared with WT controls, Pink1-/- rats exhibited reduced binding in Thal and PrL. Pharmacokinetic analysis of [18F]NS12137 PET provides a reproducible and specific measure of NET binding and indicates reduced NET in PD-related brain regions in Pink1-/- rats. Noninvasive in vivo [18F]NS12137 PET imaging is therefore a promising method for the study of potential therapies in the Pink1-/- rat.

Temporal trends in suicide related emergency calls by age group and gender from 2014 to 2023

A Refined Bulk P–I–N Structure in All-Polymer Solar Cells To Achieve 20.1% Efficiency and Improved Stability

Optimised RFO tuned RF-DETR model for precision urine microscopy for renal and systemic disease diagnosis

Formaldehyde-Mediated Initial Carbon–Carbon Bond Formation in Zeolite-Catalyzed Methanol-to-Hydrocarbon Conversion

Enhancing pathological feature discrimination in diabetic retinopathy multi-classification with self-paced progressive multi-scale training

Ammonia Synthesis under Ambient Conditions: Insights into Water–Nitrogen–Magnetite Interfaces

Socioeconomic status and partaking in air pollution monitoring are associated with cookstove usage across three peri-urban communities in sub-Saharan Africa

Abstract While transitioning from polluting cooking fuels (e.g. wood, charcoal) to cleaner fuels, like liquefied petroleum gas (LPG), can lead to time savings, the amount of time saved is uncertain due to minimal stove use monitoring (SUM) data. Approximately three months (mean:82 days (SD:41)) of SUM data from Geocene temperature sensors was collected from 186 households in Mbalmayo, Cameroon; Obuasi, Ghana and Eldoret, Kenya. Households exclusively using LPG (mean:1 h 22 min/day) cooked for two hours/day less than those stacking LPG and polluting fuels (3 h 19 min/day), and almost three hours/day less than those exclusively using polluting fuels (4 h 10 min/day). Financially insecure households exclusively using polluting fuels cooked for ~ 45 min longer (4 h 29 min) than financially secure households (3 h 45 min). During a 24-hour household air pollution (HAP) monitoring period, average cooking time was 38 min longer (3 h 48 min vs. 3 h 10 min) and households cooked nearly once more per day (3.63 events) than during the remaining SUM period (2.72 events). Longer cooking times among financially insecure polluting fuel users suggests that LPG access may disproportionately benefit poorer households via greater time savings. Households may cook for longer-than-normal when monitored for HAP.

Determination of Intermolecular Distances in Dilute Solutions of Macroions and Their Direct Correlations with Self-Assembly and Macrophase Transitions

Research on the material properties of concrete in subway stations after in service for 50 years

Speed Matters: Directed Assembly of Icosahedral HPV Virus-Like Particles

Diffusion probabilistic model for Tibetan painted sketch extraction

Ba₇Nb₄MoO₂₀: A Proton or Oxide Ion Conductor?

Correction: Developing a novel hybrid model based on GRU deep neural network and Whale optimization algorithm for precise forecasting of river’s streamflow

Mechanochemical Synthesis of H ^– Materials: Hydrogen-Rich Perovskite Oxyhydrides with Lattice Strain as an Ammonia Synthesis Catalyst