Browse Articles

Clarifying interactions between genotype and environment and management in chickpea by focusing on plant and soil attributes

Plant hormone jasmonic acid reduces anxiety behavior in mice

Abstract Anxiety disorders are a leading cause of disability worldwide and major contributors to the global disease burden. In this study, we investigated the anxiolytic-like effects of plant-derived molecules in mice. Jasmonic acid (JA), a major plant hormone, has been identified as an injury response-related hormone in higher plants. We found that the oral, intraperitoneal, and intraventricular administration of JA in mice demonstrated anxiolytic-like effects in an elevated plus maze test. Additionally, JA exhibited anxiolytic-like effects in mice undergoing open field and novel environment feeding suppression tests. In addition, we found that the anxiolytic-like effects of JA were mediated by serotonin 5-HT1A receptors and central dopamine D1 receptor systems. Our findings reveal a novel role of JA in exerting anxiolytic-like effects in animals and suggest that plant hormones, such as JA, could serve as potential compounds for treating anxiety disorders.

The depth of tumor hierarchy and its impact on hypertumor susceptibility

Evaluation of dipeptidyl peptidase-4 inhibitor-associated gastrointestinal symptoms using the prescription claims database

Fungal endophytes influence soil organic carbon and nitrogen fractions promoting carbon sequestration and improving grain yield in soybean

Quantum memory assisted entropic uncertainty relation as a signature of quantum phase transition in the spin XXZ model

Catalytic allylation of native hexoses and pentoses in water with indium

Author Correction: Root decomposition in Urochloa decumbens pastures fertilized with increasing nitrogen doses or intercropped with Calopogonium mucunoides

Author Correction: Green-synthesized silver nanoparticle-enhanced nanofiltration mixed matrix membranes for high-performance water purification

Metformin inhibits melanin synthesis and melanosome transfer through the cAMP pathway

The full lethal impact of massive cuts to international food aid

The role and function validation of P2RX4 as a novel cancer biomarker in pan-cancer analysis

Global modules robustly emerge from local interactions and smooth gradients

Childhood maltreatment influences coping in youths with major depression and bipolar depression through resilience and impulsivity

Mathematician who reshaped theory of symmetry wins Abel Prize

Comparing large Language models and human annotators in latent content analysis of sentiment, political leaning, emotional intensity and sarcasm

Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet

The sixth finger illusion induced by palm outside stroking shows stable ownership and independence

Efficient 22 nm GNRFET PTLA using low power trimode technique for high speed processor

Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption