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Development of simulated human milk ultrafiltrate (SHMUF) for analysis of native particles in human milk
Deep dive: How I use robots to survey coral reefs
Prognostic value of circulating HPV cell-free DNA in cervical cancer using liquid biopsy
Application of HEMA-AAm copolymer to achieve faster optical tissue transparency for 2D/3D fluorescence imaging
Crosslinking a nanocomposite by zirconium sulfate to synthesize a high-durable new-generation polymer gel
Peptides developed against receptor binding sites of the E glycoprotein neutralize tick-borne encephalitis virus
Publisher Correction: Sleep and stress in athletes with disabilities around the 2021 Tokyo Paralympic games during the pandemic
Intranasal oxytocin modulates brain activity during emotional processing in children with treatment resistant conduct problems
Abstract One of the most highly replicated neural correlates of Conduct Problems (CP) is amygdala hypoactivity to another person’s fear. We recently reported that this correlate was only observed in boys with persistent CP (i.e. antisocial behaviour that persisted following a gold-standard psychological intervention), suggesting that amygdala hypoactivity to fear could be an important neural signature for treatment-resistant CP, and a putative target for future treatments. Potential treatment candidates include the oxytocin system, as this has been reported to modulate amygdala activity and social behaviour across species. Further, in adults with antisocial personality disorder, intranasal oxytocin improved facial emotion recognition for fearful and happy faces. However, to-date, no-one has studied whether intranasal oxytocin can normalise neural processing differences in children with CP. Twenty boys (mean age 9.85±1.26 years) with persistent CP underwent functional magnetic resonance imaging in a within-subject randomised control design to investigate whether, compared to placebo, a single-dose of intranasal oxytocin could ‘shift’ abnormal neural processing to fear. Oxytocin failed to reduce amygdala hypoactivity to fearful faces, but increased activation in the posterior cingulate cortex / precuneus to happy faces. These findings tentatively suggest that intranasal oxytocin may promote a more neurotypical profile in treatment-resistant CP children, therefore, supporting the merit of investigating oxytocin in further larger clinical studies in this population.
No hyponatremia despite continuous plasma sodium decline in female runners during a seven stage ultramarathon
Adaptive feature interaction enhancement network for text classification
Abstract Text classification aims to establish text distinctions, which face difficulty in capturing global text semantics and local details. To address this issue, we propose an Adaptive Feature Interactive Enhancement Network (AFIENet). Specifically, AFIENet uses two branches to model the text globally and locally. The adaptive segmentation module in the local network can dynamically split the text and capture key phrases, while the global network grasps the overall central semantics. After obtaining the results from the two branches, an interaction gate is designed to evaluate the confidence of the global features and selectively fuse them with the local features effectively. Finally, the interactively enhanced features are re-input into the classifier to improve text classification performance. Experiment results show that our proposed method can effectively enhance the performance of backbone networks such as TextCNN, RNN, and Transformer with fewer parameters. AFIENet achieved an average accuracy of 3.82% and an F1-score of 3.88% improvement across the three datasets when using Transformer as the backbone network. The comparable results to MacBERT that obtained with static word vectors also reflect the applicability of the proposed method.
Design, development, and preclinical evaluation of pirfenidone-loaded nanostructured lipid carriers for pulmonary delivery
PET imaging of differentiated thyroid cancer with thyrotropin-alfa
The best foods for healthy ageing ― and the worst
Adaptive non-parametric kernel density estimation for under-frequency load shedding with electric vehicles and renewable power uncertainty
Preparation and preliminary studies of porous fish collagen and chitosan materials enriched with microcapsules containing an active ingredient
Abstract This study explores the development and characterization of advanced composite materials combining fish collagen and chitosan, enhanced with chitosan-based microcapsules encapsulating an active ingredient—Calendula officinalis flower extract—hrough ionic gelation using various surfactants (Span 80, Tween 80 and Span80/Tween 80). Collagen was successfully extracted from northern pike scales and integrated with chitosan to create porous, three-dimensional matrices by the lyophilization process. Various amounts of microcapsules were incorporated into the matrices, and the structure of the obtained materials, their mechanical properties, swelling capacity, and susceptibility to degradation were assessed. Matrices with microcapsules exhibited high porosity, substantial swelling capacity, and improved mechanical properties compared to matrices without them. Microcapsules enabled the controlled release of active ingredients, demonstrating potential applications cosmetic industry. This research aligns with current trends in the cosmetics industry, such as the use of sustainable and eco-friendly materials derived from renewable resources like fish waste, the emphasis on natural and bioactive ingredients such as plant extracts, and the development of advanced delivery systems for controlled release of active compounds. The study addresses consumer demand for biodegradable and non-toxic materials, reducing environmental impact while enhancing product efficacy and safety.
Somatosensory false feedback biases emotional ratings through interoceptive embodiment
Abstract Mismatches between perceived and veridical physiological signals during false feedback (FFB) can bias emotional judgements. Paradigms using auditory FFB suggest perceived changes in heart rate (HR) increase ratings of emotional intensity irrespective of feedback type (increased or decreased HR), implicating right anterior insula as a mismatch comparator between exteroceptive and interoceptive information. However, few paradigms have examined effects of somatosensory FFB. Participants rated the emotional intensity of randomized facial expressions while they received 20 s blocks of pulsatile somatosensory stimulation at rates higher than HR, lower than HR, equivalent to HR, or no stimulation during a functional magnetic resonance neuroimaging scan. FFB exerted a bidirectional effect on reported intensity ratings of the emotional faces, increasing over the course of each 20 s stimulation block. Neuroimaging showed FFB engaging regions indicative of affective touch processing, embodiment, and reflex suppression. Contrasting higher vs. lower HR FFB revealed engagement of right insula and centres supporting socio-emotional processing. Results indicate that exposure to pulsatile somatosensory stimulation can influence emotional judgements though its progressive embodiment as a perceived interoceptive arousal state, biasing how affective salience is ascribed to external stimuli. Results are consistent with multimodal integration of priors and prediction-error signalling in shaping perceptual judgments.