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Alleviating head-mounted weight burden for neural imaging in freely-behaving rodents

Abstract The recently developed miniaturized head-mounted two-photon (2P) imaging devices have served as a valuable tool for neuroscientists, enabling real-time functional neural imaging in freely-behaving animals. Although the current 2P fiberscopes and miniscopes are lightweight, the weight of any potential additional accessories inevitably imposes a burden on the animal. Here, we present a buoyancy levitation method to alleviate head-mounted weight burden on mice. By utilizing the buoyance of a helium-filled balloon to counteract the additional weight of up to 7 g, mice’ motion behavior remains largely unaffected by the added load. Neuroimage analysis provides new insights into the effects of weight burden on neural activities. This easy-to-implement method offers a platform for studying neural network function in animals, effectively freeing them from the burden of head-mounted weight.

Perceptions, Practices, and Treatment Approaches of Indian Physicians Towards Ceftriaxone-sulbactam-ethylenediaminetetraacetic Acid (CSE) in Managing Complicated Urinary Tract Infections (cUTI)

IoT-based bed and ventilator management system during the COVID-19 pandemic

A Tangled Web of Blood and Clots – A Retrospective Prevalence Study of Anemia in CVT

Effect of boriding time on the effective thermal diffusivity of the borided AISI 1018 steel

Mortality Predictors in Shock

Asymmetric effects of natural and socioeconomic factors on PM2.5 pollution in Chinese counties

A Case of Epilepsia Partialis Continua following Measles Encephalitis in an Immunocompromised Adult

5G-based SharkNet protocol adaptation and wireless communication links

Comparison of Diastolic Shock Index with That of Lactates in Predicting Outcomes In Septic Shock – A Prospective Study

Degradation modeling and remaining useful life prediction for electronic device under multiple stress influences

Emerging Challenge of Antibiotic Resistance: Combination of Ceftazidime – Avibactam and Aztreonam under Threat

Preparation of a Brucella multiepitope fusion protein based on bioinformatics and its application in serological diagnosis of human brucellosis

Evaluation of Efficacy of Extended Prone Ventilation in Patients with Acute Respiratory Distress Syndrome in a Tertiary Care Centre

Consistent, highly throughput and space scalable distributed architecture for layered NoSQL data store

Heat and Moisture Exchangers (HMEs) vs Heated Humidifiers (HHs) in the Management of Mechanical Ventilated Adult Patients

A study on the relationship between the weight-adjusted waist index and kidney stone prevalence mediated by diabetes: data from NHANES 2007–2018

Novel Experimental Validation of A Critical Care Ventilator Using Real-time Simulated Patient Clinical Models and Stringent Automated Data Verification, First Time in India

Transcriptomic profiles reveal hormonal regulation of sugar-induced stolon initiation in potato

Dengue NS1 Antigen Positivity in the Blood and its Impact on Platelet Counts