Browse Articles

Activation of the stress-activated protein kinase JNK in response to herpes simplex virus-1 infection coordinates transition of BRD4 from chromosome association to transcription elongation

Doping Bulky Fluorinated Organic Anion to Construct Highly Efficient Anion‐π ⁺ Type Photosensitizers for Cancer Phototheranostics

Abstract Anion‐π + type photosensitizers with aggregation‐induced emission (AIE) feature have demonstrated promising potential in photodynamic therapy (PDT) against cancer. However, previous reports mainly focused on modifying the π + core but often overlooked the crucial role of anions. Herein, we present a facile strategy to modulate the fluorescence intensity and cellular uptake of anion‐π + type AIE photosensitizers by doping bulky fluorinated organic anions into nanoparticles (NPs). Anion‐π + type AIE photosensitizer DPBCF‐Br with different ratios of bulky anions (TB or FTB) were encapsulated into DSPE‐PEG 2000 to obtain NPs (named DF‐TB X or DF‐FTB X , X denotes the molar ratios of TB or FTB to DPBCF‐Br). Expectedly, as the doping molar ratios increased, a progressive enhancement in fluorescence intensity of the obtained NPs was observed. This can be ascribed to the steric effect of bulky organic anions and the formation of a hydrophobic environment within the NPs. Interestingly, the optimal cellular uptake was achieved at X  = 8 in DF‐TB 8 and DF‐FTB 8 , resulting from the balance between lipophilicity and electronegativity. Ultimately, DF‐FTB 8 demonstrated outstanding cellular imaging capabilities and high intracellular reactive oxygen species generation, achieving efficient cancer phototheranostics. This facile bulky anion doping strategy will pave a new way for the construction of robust anion‐π + type photosensitizers.

Triptorelin associated adverse events evaluated using FAERS pharmacovigilance data

Multifunctional molecular agent for tau-targeted combinational therapy of Alzheimer’s disease

Plasmon‐Ferroelectric Induced Multifield Coupling Effect Accelerates Charge Spatial Separation for Boosting Tandem Photoredox Catalysis

Abstract Integrating solar‐driven CO 2 reduction with organic oxidation is regarded as an ideal strategy for achieving carbon neutrality. However, further enhancement of photocatalytic efficiency is persistently blocked by low photogenerated carrier yields and unavoidable fast bulk electron/hole recombination. Herein, we propose to design a plasmonic‐ferroelectric heterojunction (WO 3‐x /K 4 Nb 6 O 17 ), which enhances localized electromagnetic field and ferroelectric polarization field simultaneously through the cooperative coupling of localized surface plasmon resonance (LSPR) effect in WO 3‐x and ferroelectric polarization in K 4 Nb 6 O 17 , thereby not only promoting energetic hot‐carriers generation, but also accelerating bulk charge separation. Ultimately, hot‐electrons and photoelectrons are directionally transferred and extracted to K 4 Nb 6 O 17 surface for CO 2 reduction, whereas massive holes are accumulated in WO 3‐x for benzylicalcohol activation. Under mild conditions, WO 3‐x /K 4 Nb 6 O 17 exhibits superior CO yield (294.76 µmol g −1 h −1 ), which is 9.87 and 6.27‐folds higher than that of K 4 Nb 6 O 17 and WO 3‐x , respectively. Meanwhile, compared to the simple dehydrogenation of benzylicalcohol to benzaldehyde in K 4 Nb 6 O 17 and WO 3‐x , WO 3‐x /K 4 Nb 6 O 17 prefers to trigger benzylicalcohol C─C coupling for directed production of more value‐added hydrobenzoin (313.15 µmol g −1 h −1 ). This work would open a conceptual vista for designing multifield coupling structures to facilitate charge spatial separation and directional transfer, which would inspire further establishment of efficient novel photocatalysts and solar‐to‐fuel conversion systems to meet the green and sustainable development goals.

Analysis of spatial correlation network and influencing factors of green energy efficiency in urban agglomerations

N4BP1 is a nucleocytoplasmic shuttling protein and recognizes aggregates of the ubiquitin-like protein NEDD8 to protect cells under heat shock

The effect of tolvaptan on renal progression and systemic inflammation in ADPKD

The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells

A robust assessment and treatment of selected organochlorine pesticides and heavy metals in industrial wastewater using nanoparticles: a case study in Nigeria

A non-coding RNA circGNAI2 suppresses triple-negative breast cancer progression by sponging miR-454-3p to inhibit the VGLL4-STAT3 signaling

Isotope Engineering of Tetraphenylethylene: Aggregate‐Dependent Enhancement of Luminescence Efficiency

Abstract Aggregation‐induced emission (AIE) luminogens, exemplified by tetraphenylethylene (TPE), exhibit enhanced fluorescence in aggregated states and have promising applications in display, photodetectors, fluorescent probes, bioimaging, and biomedicine. This study investigates the influence of varying degrees of deuteration on the photophysical properties of TPE across different aggregation states. Through the synthesis of partially and fully deuterated TPE derivatives (TPE‐5d, TPE‐10d, and TPE‐20d), combined with steady‐state fluorescence spectroscopy, time‐resolved fluorescence measurements, transient absorption spectroscopy, and density functional theory (DFT) calculations, we elucidate the dual role of deuteration in modulating nonradiative decay pathways. In loosely packed nanoaggregates, increased deuteration enhances photoluminescence quantum yields (PLQY) and extends fluorescence lifetimes by reducing internal conversion rates. Conversely, in tightly packed crystalline states, deuteration leads to decreased PLQY and shortened lifetimes, attributable to the Duschinsky rotation effect (DRE), which enhances inter‐mode coupling and internal conversion. Additionally, deuteration significantly prolongs the operational lifetime of blue organic light‐emitting diode (OLED) devices, doubling the device lifespan in TPE‐20d compared to TPE. This work underscores the necessity of evaluating structure–property relationships at the aggregate level, rather than solely at the molecular level, to fully comprehend and optimize AIE phenomena. These findings highlight the potential of isotope engineering in designing durable and efficient AIE luminogens for applications in optoelectronics and bioimaging.

Diagnostic value of magnetic controlled capsule endoscopy in patients with chronic abdominal pain: a retrospective two-center study

Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

Feature-guided multilayer encoding–decoding network for segmentation for 3D intraoral scan data

The chromatin remodeling factor BAP18 promotes non–small cell lung cancer progression via the recruitment of β-catenin with the transcriptional coactivator complex ACTL6A–PAF1

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Abstract These studies reveal the first structure of Clostridium acetobutylicum alcohol dehydrogenase (CaADH), a protein exhibiting remarkable substrate promiscuity and stereochemical fidelity. The CaADH enzyme is utilized here for synthesizing 20 potential aryl isoserine side chains for the Taxotere family of tubulin‐binding chemotherapeutics. The approach involves dynamic reductive kinetic resolution (DYRKR) upon the corresponding α‐chloro‐β‐keto esters, showing high D‐ syn stereoselectivity, including those leading to the clinically relevant milataxel (Ar = 2‐furyl) and simotaxel (Ar = 2‐thienyl) side chains. Furthermore, various cross‐coupling chemistries performed on the p ‐bromophenyl isoserine side chain significantly enhance the structural diversity of the taxoid side chain library obtained (16 additional taxoid side chains). The CaADH structure is notable: (i) the nicotinamide cofactor is bound in an anti‐ conformation, with the amide carbonyl occupying the ketone binding pocket, and (ii) a flexible loop near the active site likely contributes to the remarkable substrate promiscuity observed in CaADH. We present our perspective on the dynamic nature of the CaADH active site through molecular dynamics simulation, proposing a halogen bonding model as a potential mechanism for the remarkable selectivity for an ( S )‐configured C─Cl bond, in addition to the D‐facial selectivity, demonstrated across 20 diverse substrates by this remarkable short‐chain dehydrogenase enzyme.

Emergence of the zoonotic bacterium Necropsobacter rosorum in nutria Myocastor coypus with implications for wildlife and human health

TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype

When Bigger is Better: Lanthanum Complexes of Bis(phenoxy‐amidine) FAlen Ligands as Unique Catalysts for the Isoselective Ring‐Opening Polymerization of Racemic β‐Lactones

Abstract Discrete yttrium and lanthanum complexes supported by new bis(phenoxy‐amidine) ligands have been prepared in high yields. Some of these so‐called FAlen ligands, when coordinated onto the large La 3+ in contrast to the small Y 3+ , can adopt an η 3 coordination mode of both amidine moieties. These La‐FAlen complexes, either previously isolated or conveniently prepared in situ, act as highly efficient ROP catalysts of simple and functional β‐propiolactones rac ‐BL R (R = Me, CH 2 O i Pr, CH 2 OSi t BuMe 2 ) under mild conditions, returning the corresponding linear polymers PBL R with high control over the molecular weights and narrow dispersities. More uniquely, when substituents with appropriate bulkiness are installed on the phenoxy and amidine moieties, the polymers all feature high isotacticity ( P m up to 0.93). High activity and isoselectivity are maintained, no matter the nature and polarity of the solvent used.