Browse Articles

Chemical reprogramming of human blood cells

Correction: Structural insights into the Caprin-2 HR1 domain in canonical Wnt signaling

Integrating Hydrophobic and Hydrophilic Building Blocks for High‐Performance Organic Electrochemical Transistors and Biosensing

Abstract Organic electrochemical transistors (OECTs) with mixed ionic‒electronic transport features have demonstrated significant potential in biosensing applications. Semiconductor polymers grafted with hydrophilic side chains have notably enhanced performance and applications. However, water‐induced overswelling and doping in biocompatible aqueous environments hinder high‐sensitivity detection. In this study, we introduce two block copolymers, DPP ‐b‐ Pg2T‐T and NDI ‐b‐ Pg2T‐T, which integrate both hydrophobic and hydrophilic segments to achieve balanced ionic–electronic conductivities and the sensing performance. These materials effectively suppress swelling and water doping, resulting in low noise signals in aqueous electrolytes. Consequently, devices based on two polymer materials exhibit superior ion concentration variation performance and enhanced sensing capabilities, with an improved sensitivity to dopamine (DA) of up to 266 mV dec −1 .

Lifetime expression of egg rejection behaviour in Eurasian magpies is associated with variation in a polymorphic genetic marker

A histone variant that manages abiotic stress in plants

ZFP36L1 and L2 as novel antiviral factors for Crimean-Congo hemorrhagic fever virus via interaction with viral nucleoprotein

A role for Myosin in triggering and executing amnioserosa cell delaminations during dorsal closure

Abstract The remodeling of epithelial tissues is a critical process in morphogenesis, often involving the apoptotic removal of individual cells while preserving tissue integrity. In Drosophila , the amnioserosa—a highly dynamic extra-embryonic tissue—undergoes extensive remodeling, culminating in its complete elimination at the end of dorsal closure. While apoptotic cell delaminations in the amnioserosa have been proposed to contribute to dorsal closure, the cellular mechanisms underlying this process remain poorly understood. In this study, we have investigated actomyosin dynamics during cell delaminations and analyzed the consequences of perturbing non-muscle Myosin activity globally in the entire tissue as well as locally in groups of cells. We found that Myosin plays an essential role in both triggering and executing cell delaminations, with high Myosin contractility promoting cell delamination via caspase activation. Additionally, our results suggest that cell delaminations are governed by both cell-autonomous Myosin dynamics and mechanical cues from the tissue environment. Together, these findings provide new insights into the regulation of epithelial cell removal and the complex interplay between apoptotic and mechanical signals during tissue remodeling.

Author Correction: Modelling human brain development and disease with organoids

Small molecule agonist TPC2-A1-N increases intracellular Ca2+ independent of two-pore channels

Dual‐Mode Strain Relief via Zinc Acetate Enables High‐Efficiency InP Quantum Dot Light‐Emitting Diodes

Abstract Heteroepitaxial shell growth on quantum dots (QDs) is essential for tailoring carrier dynamics but is often hampered by core–shell interface strain, which becomes more prominent in environmentally friendly InP QDs due to their significant size effect. Although post‐treatment of InP cores with zinc compounds is a common approach to alleviate interface strain, conventional synthesis methods often fail to achieve effective doping, typically leaving zinc on the core surface rather than within the lattice. Herein, we present a dual‐mode strain relief strategy using the small‐molecule precursor Zn(Ac) 2 . Its ionic bonding character and low steric hindrance enable efficient Zn doping into the InP core and promote uniform epitaxial shell growth, leading to a 50% reduction in interfacial strain and a near‐unity photoluminescence quantum yield in InP QDs. This approach simultaneously addresses two major sources of strain: lattice mismatch between the core and shell and steric hindrance from bulky surface ligands. The fabricated green InP‐based QLED achieved a high external quantum efficiency of 26.3% and a current efficiency of 108.3 cd A −1 . We believe this strategy provides a general and scalable strain engineering platform for QDs, with broad applicability across various material systems.

A systematic review and dose-response meta-analysis of red blood cell distribution width to albumin ratio as mortality predictor in cardiovascular disease

Abstract Red blood cell distribution width (RDW) and albumin separately have been used as mortality predictors for people with cardiovascular disease (CVD). This study aims to explore whether the RDW-to-albumin ratio (RAR) could provide a better prognostication in the CVD population. A systematic search of suitable studies was conducted in PubMed, Web of Science, Scopus, and ProQuest until February 1, 2024. Mortality and length of stay outcomes of the highest vs. lowest RAR tertile were pooled using hazard ratio (HR) and standardized mean difference (SMD), respectively. Additionally, a dose-response meta-analysis was performed. Publication bias, subgroup, and sensitivity analyses were conducted to address the causes of heterogeneity. Sixteen studies with 30,933 participants were included in the meta-analysis. Pooled results showed that patients with higher RAR faced a significantly higher risk of mortality (HR 1.88, 95%CI 1.59–2.23). Nonlinearity was observed in the dose-response relationship. Using a reference value of 3 ml/g, each 1 ml/g increase in RAR corresponded to a 27% rise in the mortality HR (HR 1.27, 95%CI 1.16–1.39). Our study demonstrated that elevated RAR values were significantly associated with higher mortality in CVD and exhibited a positive dose-response relationship, suggesting its potential as a novel prognostic biomarker for CVD.

DNA-repair-driven cell death compels us to rethink cancer therapies

Cytochrome P450 2W1: Identification of new inhibitors, active site ligands, and pharmacophores

Room temperature operated short-wave infrared phototransistor optimized via MXene-based metamaterial absorber structure

Newcastle disease virus exploits the phospholipid flippase ATP11c–CDC50A complex to promote viral infection

Advancing Solid‐State Calcium Batteries: Achieving Fast Ionic Conductivity at Near Ambient Conditions in Calcium Hydridoborates

Abstract All‐solid‐state batteries based on abundant elements, such as calcium, offer a promising route to safer, cheaper, and more sustainable energy storage. Here, we report a series of fast Ca 2+ ‐conducting compounds of methylamine calcium tetrahydridoborates, Ca(BH 4 ) 2 · x CH 3 NH 2 (0 <  x  < 4.9) and related nanocomposites stabilized by inert MgO nanoparticles. Three new crystal structures are identified: a three‐dimensional network of octahedrally coordinated Ca 2+ complexes for x  = 1, a molecular structure of neutral complexes for x  = 4, and a structure of cationic complexes for x  = 6. The thermal stability generally decreases with increasing CH 3 NH 2 content, and samples with x  > 2 slowly release CH 3 NH 2 in “open” atmosphere at room temperature, but are stabilized in “closed” environments, e.g. capillaries. The ionic conductivity increases with CH 3 NH 2 content and correlates with increased void space and structural flexibility, reaching σ (Ca 2+ ) = 5.0·10 −5  S cm −1 at 60 °C for x  = 4. Moreover, the effect of nanocomposite formation provides mechanical stability and a doubling of the ionic conductivity for Ca(BH 4 ) 2 ·4CH 3 NH 2  − MgO (50 wt%), reaching σ (Ca 2+ ) = 1.3·10 −4 S cm −1 at 60 °C. These findings demonstrate how local structure and nanoscale interfacial effects govern calcium transport, offering new design principles for functional calcium solid electrolytes.

Research on concept generation design of automobile seats based on human–machine co-creation

Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling

Realizing Unconventional Tandem Nitrate Reduction for Efficient Ammonia Electrosynthesis Enabled by Co, Fe Dual‐Site Conjugated Metal Organic Frameworks

Abstract The electrochemical nitrate‐to‐ammonia reduction reaction (NO 3 RR) offers a sustainable route for carbon‐neutral chemical synthesis, while the intricate multi‐electron/proton transfer processes and unstable intermediates pose significant challenges in attaining high selectivity and efficiency. This study demonstrates a Co, Fe bimetallic conjugated metal organic frameworks (CoFe‐cMOFs) that enable efficient NO 3 RR via an unconventional [6 + 2] electron‐transfer tandem pathway. Unlike the traditional [2 + 6] tandem pathway, the Fe sites predominantly reduce NO 3− to *NH 2 OH intermediate, which subsequently spills over onto the Co sites for further protonation. This unconventional tandem pathway effectively avoids the release of NO 2− and guarantees selective NH 3 production. The CoFe‐cMOFs achieve 94.3% NH 3 ‐producing Faradaic efficiency with a yield rate of 14.1 mg h −1 cm −2 in neutral electrolyte. The Zn‐NO 3 − battery prototype incorporating CoFe‐cMOFs exhibits 3.6 mW cm −2 peak power density with stable NH 3 production. This work proposes a mechanistic breakthrough in tandem pathway regulation for selective electrochemical ammonia synthesis.

Polycation Engineering in Polymeric Metal Halides Enables Tunable and Multicolor Emission from Single Transition‐Metals

Abstract Zero‐dimensional metal halides have emerged as a versatile platform for the development of light‐emitting materials, but achieving tunable or even multicolor emission from a material containing a single type of metal has proven highly challenging. Here, we leverage the “structural tolerance” of recently‐developed polymeric metal halides to integrate two distinct coordination units of a single metal into a material, thereby achieving highly tunable optical properties in single‐phase metal halides. By manipulating the steric hindrance of polycations, facilely adjustable green, red or bicolor emission can be realized in manganese bromides, which originates from controllable transformation from manganese‐bromine tetrahedra into octahedra. This design principle is further extended to polymeric copper halides, wherein broad self‐trapped exciton emissions derived from distinct copper‐iodine polyhedrons allow the emission colors to be linearly tunable from blue to yellow, encompassing pure white light, by tailoring the composition, excitation wavelength, or temperature. This study opens avenues for facile and precise modulation of the optical properties of metal halides by exploiting the intrinsic coordinative diversity of metal elements.