Integrating Hydrophobic and Hydrophilic Building Blocks for High‐Performance Organic Electrochemical Transistors and Biosensing

Abstract

Abstract Organic electrochemical transistors (OECTs) with mixed ionic‒electronic transport features have demonstrated significant potential in biosensing applications. Semiconductor polymers grafted with hydrophilic side chains have notably enhanced performance and applications. However, water‐induced overswelling and doping in biocompatible aqueous environments hinder high‐sensitivity detection. In this study, we introduce two block copolymers, DPP ‐b‐ Pg2T‐T and NDI ‐b‐ Pg2T‐T, which integrate both hydrophobic and hydrophilic segments to achieve balanced ionic–electronic conductivities and the sensing performance. These materials effectively suppress swelling and water doping, resulting in low noise signals in aqueous electrolytes. Consequently, devices based on two polymer materials exhibit superior ion concentration variation performance and enhanced sensing capabilities, with an improved sensitivity to dopamine (DA) of up to 266 mV dec −1 .