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Unveiling the causative role of promoter variant rs113823671 in MMP7 in gallbladder cancer susceptibility
Analytical strategies for identification and quantitation of heterodimers in co-formulated monoclonal antibody cocktails by native SEC-MS
Periodontal health intervention for oral health-related outcomes in older type 2 diabetes patients: a randomized controlled trial in a Chinese tertiary hospital
Physicists disagree wildly on what quantum mechanics says about reality, Nature survey shows
A systematic review and meta-analysis of the effects of Entertainment-Education interventions on persuasive health outcomes
Abstract Entertainment-Education (EE) refers to the integration of entertaining and educational components within popular media, with the objective of positively impacting social and health behaviors. This study aims to synthesize the effects of EE for health communication. In particular, the effects of EE on health knowledge, intentions, attitudes, behavior, and self-efficacy were analyzed. Further, a persuasion index was created based on the primary outcomes. Only controlled or randomized-controlled studies were considered, and after screening, K = 39 of N = 4183 studies were included. Pairwise meta-analyses were conducted to determine the effects of EE on persuasive health outcomes. Additionally, potential effects of the subgroups delivery mode, gender, healthcare, type of control group and type and taxonomy of health behavior on a weighted persuasion index were analyzed. Analyses revealed evidence for significant small to moderate effects on all outcomes, with the largest effect sizes on knowledge and self-efficacy. Subgroups seem to account for a significant amount of heterogeneity, as a significant effect could be observed for all analyzed subgroups except for healthcare and gender. The meta-analysis suggests that EE is suitable for the communication of health messages, particularly when targeting prevention topics. However, it is imperative to exercise caution when interpreting the results, and further research is needed.
Sustainable foam stabilization using red mud-derived nanoparticles for enhanced oil recovery and CO2 sequestration
Learning curve of a novice foot and ankle surgeon in minimally invasive calcaneal fracture surgery via the sinus tarsi approach
Securing the forest carbon sink for the European Union’s climate ambition
Experimentally investigating the structural capacity of slender web tapered built up plate girder with web opening
Abstract Built-up plate girders are widely used in structural applications where hot-rolled beams may not provide sufficient strength or stiffness. To achieve a cost-effective design, tapered plate girders are often employed, allowing for an optimized distribution of material by gradually varying the web depth along the span. In many practical applications, web openings are introduced to accommodate service ducts, utilities, and weight reduction, making them an essential feature in modern steel structures. However, while design codes provide well-established methods for prismatic girders, the web behavior of tapered girders with web openings remains insufficiently investigated, leading to gaps in existing predictive models. This research presents a novel equation to estimate the web capacity of tapered plate girders with web opening, considering parameters such as the panel aspect ratio, web opening size to panel average height ratio and tapering ratio. The equation was validated with the experimental results giving a maximum error of 8%. A comparative study was conducted using different methodologies of steel design standards and previous researches to evaluate their results with the experiments. The results of these methodologies demonstrated significant contradictions. Where some standards underestimated the web capacity by up to 58% while some others overestimated it by up to 45%. The presented formula gives significant improvement in designing the steel plate girders with web opening, hence in structural design. Future research may consider enhancing the equation taking into consideration widening the range of values for taken parameters or by considering more parameters regarding the girders’ geometry, loading and boundary conditions.
Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies
Graph feature selection for enhancing radiomic stability and reproducibility across multiple institutions in head and neck cancer
Folate-based binuclear Mn(II) chelates with 2,2’-bipyridine/1,10-phenanthroline as targeted anticancer agents for colon cancer cells
Abstract Researchers have shown significant interest in the chemistry of mixed ligand transition metal chelates due to their diverse applications and bonding features. Herein, we have reported the synthesis of two new binuclear Mn(II) chelates with the composition of [Mn2(FA)(Bpy)2(H2O)2Cl2].7H2O (Chelate 1) and [Mn2(FA)(Phen)2(H2O)2Cl2].7H2O (Chelate 2) (where, FA = folate anion, Bpy = 2,2’-bipyridine, Phen = 1,10-phenanthroline). The folate anion acts as a bridging ligand to obtain the binuclear complexes with the suggested composition. The chelates have been characterized by using elemental analysis, spectroscopic (FTIR, UV-vis), EI-MS and TGA techniques. Further, the results from density functional theory (DFT) computations support well the suggested structures, which indicate the development of distorted octahedral geometries around each Mn(II) center for both binuclear complexes. The sulforhodamine B (SRB) assay was used to assess the cytotoxicity of the chelates against a series of folate receptor-positive and -negative cell lines. The prepared chelates exhibit significant cytotoxic effects against folate receptor-positive cell lines, with colon cancer HCT116 cells being the most affected. Furthermore, the anticancer mechanism of action on the HCT116 cell line was investigated by analyzing the wound healing, cell cycle profile, expression of pro-apoptotic and anti-apoptotic proteins, as well as examining the morphological changes in treated cells. The results provided compelling evidence of binuclear Mn(II) chelates-induced cellular and nuclear alterations.