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Epidemiology of dengue fever in Hajjah governorate, yemen, from 2020 to 2024
Strategies for climate-resilient global wind and solar power systems
Vildagliptin modulates the microbiota and induces an immunometabolic profile compatible with neuroprotection in type 2 diabetes
Fully distributed adaptive event-triggered control with delay-aware dynamic thresholds for islanded AC microgrids
Sleuths and scientific institutions are not rivals
Association between sarcopenia and suicidal ideation in a nationwide population-based study
Metalasers with arbitrarily shaped wavefront
Complete computational design of high-efficiency Kemp elimination enzymes
Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer
Observation of elusive interaction between neutrinos and atomic nuclei
Mixed provenance of organic carbon in Northeast Atlantic temperate intertidal seagrass sediments
Optimization of separation and purification processes in diethyl ether production for improved efficiency and sustainability
Could bridging science and the arts be the key to better policies?
Effectiveness of a nurse-led pain management model following TACE: a retrospective analysis
An effective approach to cartilage regeneration using antler stem cell-conditioned medium
Africa needs to invest in science communication — here’s how
A new Drosophila model of prolonged inactivity shortens lifespan and impairs muscle function
Abstract Prolonged inactivity due to medical conditions can cause chronic muscle disuse and lead to physical incapacity and poor quality of life. Here, we developed a Drosophila model of confinement inactivity (CI) to observe its effects on lifespan and muscle function. We found that, similar to mammalian models and humans, CI negatively impacted longevity and function in Drosophila. Confined flies had impaired mobility, shorter lifespan, and reduced muscle integrity compared to their freely mobile siblings. These findings establish a new, highly efficient platform for studying long term effects of chronic sedentary behavior and muscle disuse in the genetically tractable Drosophila model. In addition, we found that temporarily removing flies from CI for scheduled bouts of forced physical exercise ameliorated negative effects, in part by improving muscle homeostasis. Finally, we tested whether muscle overexpression of 3 exercise-responsive genes, dPGC-1α , dFNDC5 , or dSesn , could prevent the negative impact of CI on fly aging, even without physical exercise. We previously established that overexpression of these factors phenocopies exercise effects in aging wild-type and disease model flies. We found that when overexpressed in muscle, dSesn prevented premature declines in endurance, and dFNDC5 protected speed and endurance. This new model can be used in the future for mechanistic studies to identify preventative and therapeutic targets for diseases associated with chronic inactivity.
A numerical study of the relevance of the electrode-tissue contact area in the application of soft coagulation
Abstract Monopolar electrocoagulation is a well-established surgical technique to achieve hemostasis by selectively destroying biological tissue through the application of high-frequency alternating current. However, this technique is associated with unwanted tissue damage. In this context, computational simulation is a valuable tool that can improve our understanding of such complex processes and highlight important application parameters in the direction of an improved control function to achieve safer and more reliable results. Despite its critical role in surgical applications, the influence of the electrode-tissue contact area has received little to no attention in previous simulation studies. To address this gap, the present study investigates the sensitivity of temperature distribution and necrotic volume formation to variations in electrode-tissue contact area. For this purpose, a multiphysics finite element model was developed to simulate HF current induced soft coagulation using a ball electrode under varying contact areas. Our findings demonstrate that variations in the contact area significantly impact temperature development and, consequently, necrosis formation. These results highlight the crucial role of the contact area in the electrocoagulation process and its associated necrosis formation. Furthermore, it was observed that when the boiling point of water is reached inside the tissue, complete necrosis has not yet formed at the contact site, which could lead to further undesired effects. Consequently, it is essential to consider the contact area in computational simulations and the development of novel control features for safer and more reliable electrocoagulation.