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Intraspecific functional traits of an invasive alien plant, Hyptis suaveolens differ with respect to land use types

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults

Case 23-2025: A 28-Year-Old Woman with Respiratory Failure and Abnormal Chest Imaging

Coherent control of anisotropic SPPs in a symmetric double-layer metal/uniaxial dielectric structure

Expanding the Treat-to-Target Toolbox for Obesity and Diabetes Care

Non-antibiotics disrupt colonization resistance against enteropathogens

Abstract Non-antibiotic drugs can alter the composition of the gut microbiome1, but they have largely unknown implications for human health2. Here we examined how non-antibiotics affect the ability of gut commensals to resist colonization by enteropathogens3. We also developed an in vitro assay to assess enteropathogen growth in drug-perturbed microbial communities. Pathogenic Gammaproteobacteria were more resistant to non-antibiotics than commensals and their post-treatment expansion was potentiated. For 28% of the 53 drugs tested, the growth of Salmonella enterica subsp. enterica serovar Typhimurium. (S. Tm) in synthetic and human stool-derived communities was increased, and similar effects were observed for other enteropathogens. Non-antibiotics promoted pathogen proliferation by inhibiting the growth of commensals, altering microbial interactions and enhancing the ability of S. Tm to exploit metabolic niches. Drugs that promoted pathogen expansion in vitro increased the intestinal S. Tm load in mice. For the antihistamine terfenadine, drug-induced disruption of colonization resistance accelerated disease onset and increased inflammation caused by S. Tm. Our findings identify non-antibiotics as previously overlooked risk factors that may contribute to the development of enteric infections.

Molecular characterization of Kawasaki disease subgroups using cell-free RNA profiling

Abstract Kawasaki disease is a pediatric vasculitis and the leading cause of acquired heart disease in children. The heterogeneous clinical presentation of Kawasaki disease complicates diagnosis and treatment, highlighting the need for molecular signatures to stratify patients into subgroups to better understand pathogenesis. We performed plasma cell-free RNA sequencing on samples from 98 patients diagnosed with Kawasaki disease, 86 febrile children (62 viral infection, 24 bacterial infection), and 5 healthy children. The Kawasaki disease patients were previously classified into one of four clinical subgroups using 14 clinical variables. Significant differences were observed in cell-free RNA transcript abundance, pathway enrichment scores, and cell type-of-origin fractions, including differences in hepatocyte injury, mitochondrial dysfunction, platelet activation, and developmental markers. This study demonstrates the utility of cell-free RNA to characterize Kawasaki disease subgroups at a molecular level. Cell-free RNA profiles may be used as biomarkers for Kawasaki disease stratification and offer new insight into the pathogenesis of specific KD phenotypes.

Snowman Sign in Pituitary Macroadenoma

Efficacy of the silicon based agent for age related decline in vestibular function

The Serendipitous Dance between Life and Death

Prognostic implications of the high sensitivity C-reactive protein to albumin ratio for major cardiovascular adverse events in patients undergoing noncardiac surgery

Cancer of Unknown Primary Site

Evaluation of serum samples in long cryopreservation for SomaScan proteomics and sex differences in elderly Japanese adults

Abstract Many biobanks store biological samples and use them for various analyses, including proteomics. Therefore, it is necessary to consider the denaturation of target proteins during long-term storage. We analyzed 16-year-old cryopreserved serum samples using the SomaScan platform, a novel proteomic assay, to determine whether adiponectin and resistin concentrations were consistent with those measured in our previous studies using a different platform. The results suggested that long-term cryopreserved serum samples could be used for future studies of at least adiponectin and resistin, which are closely related to the pathophysiology of diabetes, cardiovascular disease, and other metabolic diseases. Therefore, 7,289 SomaScan-assayed circulating proteins were compared between 20 men and 20 women aged ≥ 50 to determine sex differences. In total, 20 serum proteins showed significant sex differences. Of these, proteins that showed a more than two-fold difference in concentration between sexes contained heterodimeric forms of gonadotropic proteins such as CGA|FSHB, CGA|CGB3|CGB7, and CGA|LHB, which are the biologically active forms of these hormones. The present study is the first to report the possibility of using long-term cryopreserved serum samples for the SomaScan assay, and the results show that the SomaScan assay may be useful for analyzing sex differences focusing on gonadotropic hormones.

Risdiplam in Presymptomatic Spinal Muscular Atrophy

Correlations between human alveolar macrophage particulate matter load, air pollution particulate matter levels, and systemic inflammation markers in Mexico City

Lorundrostat Efficacy and Safety in Uncontrolled Hypertension

Formulating sustainable planning for Goulan Yao Village based on the integration of cultural landscape gene theory and spatial analysis

Abstract Traditional village cultural landscapes, as vital carriers of human civilization, face severe threats amid rapid urbanization. This study centers on Goulan Yao Village in Jiangyong County, China, applying cultural landscape gene theory combined with GIS spatial analysis. A gene information chain map and a village-specific classification and coding system were established to analyze spatial distribution and organizational patterns. Results show that the village reflects a rich cultural connotation shaped by the natural environment, religious beliefs, and ethnic customs. Its landscape gene distribution exhibits a “three-core, multi-node” pattern with dense clustering and mismatches between spatial accessibility and concentration. Based on these insights, a sustainable planning framework of “connotation preservation–spatial optimization–cultural tourism innovation” is proposed. This framework aims to offer both theoretical support and practical guidance for cultural landscape conservation and rural revitalization of Yao ethnic villages. The study not only extends the application of cultural landscape gene theory to ethnic minority settlements but also provides a methodological reference for the sustainable development of similar traditional settlements worldwide.

Progress Lost — The Unraveling of Medicaid and the Affordable Care Act

Mapping demographic variations in sense of mastery across the world a cross-national analysis of 22 countries in the global flourishing study