Browse Articles

Elucidating time divergence and biogeography of Euonymus hamiltonianus complex using complete plastome analysis

How does agricultural land become forest? I trek to find out

A chemical autonomous robotic platform for end-to-end synthesis of nanoparticles

Cryopreserved leukapheresis enables scalable and distributed CAR-T manufacturing: a multi-platform comparative study

Lithium extraction by extractant confined in Pickering emulsion

Improving CNN predictive accuracy in COVID-19 health analytics

Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4

An intelligent object detection and classification framework for assisting visually challenged persons using deep learning and improved crow search optimization

Drivers of the pre-season drought thresholds triggering earlier autumn foliar senescence in the Northern Hemisphere

Reference intervals for leukocyte cell population data in healthy adults in Zigong region, China

Six questions to ask before jumping into a spreadsheet

Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation

Characterization of prokaryotic plankton community structure in the Southern East China Sea using combined 16S-rDNA and 16S-rRNA

Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial

Effects of various static calibration postures on knee mechanics during locomotor tasks using statistical parametric mapping analysis

Near-infrared long lifetime upconversion nanoparticles for ultrasensitive microRNA detection via time-gated luminescence resonance energy transfer

C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia

Abstract Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases. As RNA editing alters the sequence of the RNA, it can affect splicing, stability, miRNA binding and may also lead to recoding of the translated protein. Recently, we analysed recoding A-to-I RNA editing in chronic lymphocytic leukaemia (CLL) and could define prognostically relevant editing patterns. However, disease relevant C-to-U RNA editing in CLL remained unexplored. In this study, we examined C-to-U RNA editing in CLL and discovered a recoding RNA editing site within the MFN1 gene (hg38; chr3:179,375,230), which has recently been described as RNA editing site in brain samples. We found that MFN1 editing was not only present in CLL samples but also in naive B cell subsets, primarily occurred at unspliced RNA and correlated with intron retention. We further identified catalytically active ADARB1 as an essential regulator for MFN1 editing. Finally, MFN1 editing correlated with prolonged time to treatment and overall survival in CLL patients. Summarizing, we identified a novel ADARB1 function as C to U editing regulator, which regulates MFN1 splicing and MFN1 S329L recoding with pathogenic relevance in CLL.

Short-range order stabilizes a cubic iron alloy in Earth’s inner core

Mediating role of online academic emotions between online presence and learning performance in blended learning environments

Decolonize scientific institutions, don’t just diversify them