Browse Articles

The need for comprehensive sleep disturbances assessment and management in breast cancer care

The influence of coach created motivation climate on student-athlete’s antisocial behavior with moral disengagement as a mediator and moderator

Unveiling public perceptions of battery technology in autonomous vehicles via topic modeling of news articles

A multicenter study on the perspectives of jordanian medical students on patient safety

Enhancing Los Angeles’ resilient energy systems amid wildfires

Prediction of the 180 day functional outcomes in aneurysmal subarachnoid hemorrhage using an optimized XGBoost model

Study on comprehensive landslide risk zoning method in open pit mines under multi factor coupling effects

Next app prediction based on graph neural networks and self-attention enhancement

Ancestral evolution of oxidase activity in a class of (S)-nicotine and (S)-6-hydroxynicotine-degrading flavoenzymes

Rising burden of pancreatic cancer in China: Trends, drivers, and future projections

Pancreatic cancer is one of the most lethal malignancies globally, with increasing incidence and mortality trends. In China, the disease burden has escalated over the past three decades, yet comprehensive national assessments remain limited. This study aims to evaluate the long-term trends, driving factors, and future projections of pancreatic cancer burden in China from 1990 to 2021. Data on incidence, prevalence, mortality, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) were extracted from the Global Burden of Disease (GBD) Study 2021. Temporal trends were analyzed using Joinpoint regression and age-period-cohort models, while decomposition analysis quantified the contributions of population aging, growth, and epidemiological change. Bayesian age-period-cohort (BAPC) models were applied to project disease burden trends through 2030. In 2021, pancreatic cancer accounted for 118,665 new cases and over 2.9 million DALYs in China, with a significantly higher burden among males. Age-standardized rates of incidence, prevalence, and DALYs increased markedly between 1990 and 2021, outpacing global trends. The burden was concentrated in older age groups and driven primarily by years of life lost. Joinpoint regression identified periods of accelerated increase after 2015. Age-period-cohort analysis revealed that disease burden rises sharply after age 50 and is highest among more recent birth cohorts. Decomposition analysis showed that population aging and epidemiological transitions were the main contributors to increased burden. Projections using BAPC models indicate that incidence, prevalence, and DALY rates will continue to rise through 2030. The burden of pancreatic cancer in China has increased substantially over the past three decades and is projected to rise further. These findings highlight the need for intensified public health interventions focused on prevention, early detection, and effective treatment strategies.

Investigation of wire arc additive manufacturing of cylindrical components by using cold metal transfer arc welding process

Pan-cancer analysis of oncogenic role of MAGOH and experiment validation in hepatocellular carcinoma

Bearing fault diagnosis based on cross image multi-attention mechanism

Evolutionary game analysis of the longitudinal integration of electronic health record based on prospect theory

Comparison of the 2021 ESC guideline with the HFA-PEFF and H2FPEF scores in diagnosing heart failure with preserved ejection fraction

A Pythagorean fuzzy MCDM model for evaluating career happiness in sports by selecting a suitable sport

Association between glucose-to-lymphocyte ratio and mortality in patients with heart failure from the MIMIC-IV database: a retrospective cohort study

Abstract The glucose-to-lymphocyte ratio (GLR) has been associated with prognosis in various inflammatory diseases. However, its relationship with mortality among critically ill patients with heart failure admitted to the intensive care unit (ICU) remains poorly understood. This study aims to assess the association between GLR levels and mortality in this population and to evaluate the prognostic predictive value of GLR. This retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV3.0) database, encompassing heart failure patients admitted between 2008 and 2022. The GLR was calculated as fasting glucose (mg/dL) divided by absolute lymphocyte count (K/µL). To evaluate the association between GLR levels and 30-day and 365-day mortality risk in heart failure patients, we employed RCS analysis, multivariable Cox regression, K-M survival curves, subgroup analyses, and ROC curves. These methods were used to assess both the prognostic relationship and the predictive accuracy of GLR. This study included a total of 14,417 patients. The association between GLR levels and all-cause mortality was found to be non-linear. In our analysis, GLR was found to be an independent predictor of both 30-day (HR 1.57, 95% CI 1.45–1.70) and 365-day mortality (HR 1.48, 95% CI 1.40–1.56). K-M survival curve analyzes showed that patients with elevated GLR levels had worse survival outcomes than patients with lower levels. Furthermore, the predictive utility of GLR appeared to exceed that of glucose or lymphocyte counts alone. GLR may be a useful tool for early identification and treatment of high-risk populations in clinical practice and may also be a potential predictor of the prognosis of patients with heart failure.

Concentration gradient of plastic debris larger than 500 μm detected across the Southwest Indian ocean

Cryptic antigens flag cancer cells to T cell therapy

Structural and functional insights into Listeria monocytogenes phage endolysin PlyP100: A promising food safety tool