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Techno-economic optimization of hybrid renewable systems for sustainable energy solutions
Deciphering highly potent natural abscisic acid agonists for binding to pyrabactin resistance 1 receptor through computational approaches
Rapid isotopic exchange in mineralogically unaltered coral skeletons
Abstract Fossil coral skeletons that retain their original aragonitic mineralogy are generally considered diagenetically unaltered and reliable paleoenvironmental archives. We investigated whether oxygen isotope exchange can occur between these skeletons and ambient sediment pore water without aragonite-to-calcite transformation, focusing on the role of skeletal microstructure in this process. Simulated diagenesis experiments using modern coral skeletons immersed in 18O-enriched artificial seawater revealed that microstructural complexity – specifically, the phylogenetically controlled arrangement of rapid accretion and thickening deposits – strongly influences isotopic exchange. Organic-rich regions within the skeleton facilitate water penetration, leading to heterogeneous isotopic alteration correlated with skeletal architecture. This provides a mechanism to modify primary isotopic compositions without obvious signs of diagenetic alteration, challenging the assumption that a preserved carbonate polymorph ensures isotopic fidelity in paleoenvironmental reconstructions and complicating the interpretation of the oxygen isotope paleo-temperature proxy in fossil aragonitic biocarbonates. However, we also observed that coral skeletons with less ultrastructural complexity exhibited lower susceptibility to isotope exchange, suggesting a criterium to identify the fossil specimens most suitable for paleoenvironmental analysis.
Enrichment process of phosphorite type REY based on the structure and geochemical features of the Zhijin Xinhua phosphorite in China
Evaluation of biological sex on endstage pathobiology and regenerative treatment of volumetric muscle loss
Abstract Volumetric muscle loss (VML) is a severe injury resulting in substantial skeletal muscle loss, leading to a complex pathology that culminates in suboptimal tissue repair and significant long-term functional deficits. This study employs a rodent model of VML to investigate the impact of biological sex on the injury pathobiology and its potential influence on the response to autologous minced muscle grafting (MMG) as a regenerative therapy. While no significant differences were observed between the end-stage male and female responses to VML, both male and female subjects appeared to benefit from MMG treatment. Females demonstrated improved neuromuscular function, while males exhibited reduced fibrosis at the site of injury. Additional differences in the wound healing response included distinct variations in myofiber characteristics, with females exhibiting a lower proportion of Type 2a fibers and elevated levels of myogenin. These findings suggest that regenerative therapies, such as MMG, may exhibit sex-specific benefits. Future studies will further explore sexual dimorphism in the acute response to injury to identify potential therapeutic targets that may yield greater therapeutic efficacy for each sex.
1D thermoembolization model using CT imaging data for porcine liver
Enhanced schizophrenia detection using multichannel EEG and CAOA-RST-based feature selection
Treatment outcomes in cavitary multidrug-resistant/rifampicin-resistant tuberculosis and risk factors for cavity closure: a retrospective cohort study in Southwest China
SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy
Independent evolution of betulin biosynthesis in Inonotus obliquus
A numerical study of site effect and dynamic response of staged excavation supported by soil nail walls
Rapid detection of antibiotic resistance in Burkholderia pseudomallei using MALDI-TOF mass spectrometry
Increased plasma GPNMB levels in patients with parkinson’s disease and cognitive impairment
The evolution law of mining stress concentration effect and mining pressure manifestation mechanism under different pushing methods in valley landforms
Cold atmospheric plasma effectively kills chordoma cells through induction of intracellular reactive oxygen species
Abstract Chordomas remain one of the most difficult-to-treat of skull base tumors. The best chance of survival and cure to date is with en bloc radical surgical resection, followed by adjuvant radiotherapy. Oftentimes, tumor infiltration into functionally critical, or difficult-to-access areas, precludes optimal resection. The median overall survival for these tumors is 116 months. Cold atmospheric plasma (CAP) is generated by applying a high voltage electric field to helium or argon feed gases, resulting in reactive atmospheric species. Over the past decade, CAP has been applied experimentally in a number of oncologic conditions and has demonstrated anti-tumor effects both in vitro and in vivo. Additionally, CAP has been shown to increase cancer cells’ sensitivity to radiation and could therefore be a useful tool in improving chordoma recurrence rates as an intraoperative adjuvant therapy to the current standard of care. To date, there are no studies in the literature examining the efficacy of CAP in inducing cytotoxicity in chordoma. We treated CH2, CH7 and UM-Chor1 chordoma cells with CAP, measuring resulting cell viability and intracellular ROS accumulation. Here, we show a dose-dependent increase in intracellular ROS and cell death with direct CAP exposure in vitro, finding an exquisite sensitivity of chordoma cells to CAP-mediated cytotoxicity.