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Health anxiety by proxy differs in phenomenology between parents and dog owners

Abstract Health anxiety by proxy refers to excessive concerns or preoccupation that a loved one may be suffering from or may acquire a serious illness. Although research with parents suggests that this condition may be highly prevalent, assessment has been limited in terms of attachment figures other than children. Dogs take the role of children in many families and the dog owners and parents show opposing patterns, though the underlying mechanisms are currently unknown attachment between humans and dogs shares important characteristics with the child-parent attachment. Thus, for the first time, we investigated whether health anxiety by proxy is also present in childless dog owners. To this end, we adapted an existing measure of health anxiety by proxy for parents to the situation of dog owners and used the existing parent and adapted dog owner questionnaires to gather data from dog-less parents (N = 204) and childless dog owners (N = 200). Overall, we found comparable distributions of health anxiety by proxy in both subsamples and high internal consistencies for both questionnaires. Interestingly, dog owners reported higher levels of health anxiety by proxy than parents. In both subsamples, health anxiety by proxy was linked to depressive symptoms and health anxiety, with these associations being stronger in parents than in dog owners. Moreover, while health anxiety by proxy and attachment towards children were negatively associated in parents, we found the opposite association in dog owners. Taken together, these findings provide the first evidence for the existence of health anxiety by proxy in dog owners, while suggesting that the phenomenology of the condition may differ between parents and dog owners.

Biosynthesis of Unnatural Cyclodipeptides through Genetic Code Expansion and Cyclodipeptide Synthase Evolution

Multifunctional intercalants create stable subnanochannels in MoS2 membranes for wastewater treatment

Abstract MoS2 nanosheets, featuring high chemical and mechanical stability, offer immense promise as building blocks for high-performance two-dimensional (2D) membranes. However, engineering these membranes to achieve tailored channel dimensions and chemistry while maintaining sufficient stability remains a significant challenge, impeding their real-world applications. Herein, we demonstrate the multifunctionality of polymeric quaternary ammoniums as intercalants in MoS2 membranes, enabling the creation of selective, stable 2D subnanochannels in MoS2 membranes. These intercalants fulfil three key roles: they define and secure the channel width at ~5 Å without disrupting the channel order, impart substantial positive charges to regulate the microenvironment within the channel, and establish strong non-covalent interactions with the electron-rich MoS2 planes to stabilize the channels. Consequently, the resulting membranes exhibit superior stability across various aqueous environments, particularly showing excellent tolerance under highly acidic (1 M H2SO4) conditions. During harsh pressure-driven crossflow operations, the membranes demonstrate fast water permeation while maintaining high rejection (> 90%) and selectivity for heavy metal ions in acidic wastewater. This strategy of leveraging multifunctional intercalants offers critical insights for the design of task-specific 2D membranes for demanding applications.

Correction: KIN17 modulates the WNT/β-catenin pathway and epithelial mesenchymal transition in non-small cell lung cancer

Periplasmic protein quality control at atomic level in live cells

Design and synthesis of novel small molecules targeting the Kv1.3 voltage-gated potassium ion channel

Mo Atom Rearrangement Drives Layer-Dependent Reactivity in Two-Dimensional MoS₂

CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Abstract Immune mechanisms contribute to the neuropathology of Alzheimer’s disease (AD) but the role of adaptive immune cells is unclear. Here we show that the brain CD8 + T cell compartment is dysregulated in AD patients and in the 3xTg-AD mouse model, accumulating activated CD103 – tissue-resident memory T cells that produce large amounts of granzyme K (GrK). These CD103 – CD8 + T cells originate from the circulation and migrate into the brain using LFA-1 integrin. Ablation of brain CD103 – CD8 + T cells in 3xTg-AD mice ameliorates cognitive decline and reduces neuropathology. GrK induces neuronal dysfunction and tau hyperphosphorylation in human and mouse cells via protease-activated receptor-1 (PAR-1), which is expressed at higher levels in the AD brain, revealing a key immune-mediated neurotoxic axis. We conclude that communication between CD8 + T cells and the nervous system is altered in AD, paving the way for therapies targeting T cell-dependent neurotoxic inflammation.

Genomic insights into phenol degradation by halophilic bacteria and their potential application in saline soil remediation

A Conserved Cia1–Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron–Sulfur Cluster Assembly Pathway

Constructing an auto triplet excitons supply system for photogenerated radicals in the solid state

Sparstolonin B attenuates MRSA-induced wound and peritonitis infection: in vivo, phytochemical, and computational investigation

Structural Basis for HIV-1 Maturation Inhibition by PF-46396 Determined by MAS NMR

A 100,000-Fold Increase in C–H Bond Acidity Gives Palladium a Key Advantage in C(sp ³ )–H Activation Compared to Nickel

Enhanced Sensitivity of Nonlinear Optical Signatures of Aggregation-Induced Emission

Harnessing Radical-Based Dynamic Covalent Chemistry and Supramolecular Synthon for Directional Self-Assembly

Nickel-Catalyzed Cross-Dehydrogenative Coupling of Aldehydes and Alkenes toward Skipped Enones

Convergent Paired Electrolysis Enables Electrochemical Halogen-Atom Transfer-Mediated Alkyl Radical Cross-Coupling

Photofunctionalization of Light Alkanes by FeO_<i>x</i>/BCN at 12 °C

Characterization of Aeromonas hydrophila isolated from freshwater fish with control trial

Abstract Aeromonas hydrophila is an opportunistic pathogen that is highly important for freshwater fish. In the present study, two freshwater fish species Nile tilapia (Oreochromis niloticus) and Mullet (Mugil cephalus) collected from various fish farms in Kafrelsheikh Governorate, Egypt. The fish samples were examined to determine Aeromonas hydrophila presence (A. hydrophila). In addition, a treatment trial was conducted involving four groups of Nile tilapia fish, which treated with florfenicol (FFC) and oxytetracycline (OTC) based on the antimicrobial susceptibility test results. According to the findings, 12 (20%) A. hydrophila strains were isolated from a total of 60 collected fish samples (30 of Nile tilapia and Mullet with percentages of 30% and 10%, respectively). Based on species-specific 16 S rRNA genes, six (6) isolates were identified as A. hydrophila and carried aerolysin (aerA) and hemolysin (hylA) virulence genes, with percentages of 83.3% and 50%, respectively. Whereas, the antimicrobial resistance gene results were blaTEM with percent (100%) and aadA1 (83.3%). Histopathological changes were significantly reduced in all assessed organs (liver, spleen, kidney, and gills) in the FFC group compared to the OTC-treated group. The prevalence of virulent and multidrug-resistant A. hydrophila in aquaculture poses significant risks to fish health, economic productivity, and public health.