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Highly Selective Photo-Oxidation of Methane to Methanol by Fe–Au Site-Supported SrTiO₃ Hollow Nanotubes with Oxygen Vacancies

Alkali Metal Cations Induce Pseudo-outer-sphere Oxygen Reduction Reaction Mechanism in Electrolyte-Catalyst Synergy

Programming Aptamer–Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure

The Hydroxyl Migration Mechanism through Vibrational Rocking Unveiled from Magic-Numbered Hydrated Lanthanum Oxide Clusters

Synergy between Inter- and Intramolecular Interactions on Relaxation Pathways of Oligomeric Pentacene Assemblies

Harnessing Heterogeneous Asymmetric Oxide Interface for Efficient Photodehydrogenation of Isopropanol through α-C–H Bond Activation

Reusable Noncomplementary DNA-Based Neural Network

Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

Efficient Mn²⁺ Doping in Non-Stoichiometric Cesium Lead Bromide Perovskite Quantum Dots

Capturing a Transition Phase during Birnessite-to-Spinel Transition for Efficient Water Oxidation

Strain-Promoted mRNA Transdermal Delivery by Lipoic Lipid Nanoparticles for Therapeutic Skin Genome Editing

Correction to “NIR-II Photoacoustic-Active DNA Origami Nanoantenna for Early Diagnosis and Smart Therapy of Acute Kidney Injury”

An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis

Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display

Coordination-Driven Assembly Modulates the Piezoelectric Response of Bio-Inspired Amino Acid-Based Supramolecular Materials

Quantification of Membrane Protein Conformational Free Energy from Mutations and a Single Atom

Chemical Bond Engineering in Charge-Balanced Layered TiSe₂ Derivatives: 3D Charge Transport and Lattice Anharmonicity for Exceptional Thermoelectric Performance

Electrophilic Cyanation with Carbon Isotopes: A Versatile Access to ¹³C, ¹⁴C, and ¹¹C Aryl Nitriles from Labeled NCTS

Time series anomaly detection in helpline call trends for early detection of COVID-19 spread across Sweden, 2020

Abstract Timely detection and surveillance of disease community spread is a potent tool for implementing effective public health interventions. This study investigates the National Telehealth Service (1177 helpline) across 18 regions in Sweden in 2020 to identify early signals of community transmission of COVID-19 at the beginning of the pandemic. Focusing on calls related to key COVID-19 symptoms (cough, fever, and breathing difficulties in adults), we analyze their frequency and distribution across referral categories, comparing them to 2019 data. We employ an explainable time series anomaly detection algorithm using daily call data to identify the first collective anomalies across regions. The results show that anomalies in call data were correlated with, but preceded, the first confirmed case infected in Sweden by a median of 7 days (IQR: 2.5–10.5) and the first hospitalized case infected in Sweden by a median of 13 days (IQR: 7.25–16). They also preceded the estimated onset of community spread, indicated by the absolute confirmed cases (median: 24.5, IQR: 18.25-32.5), and severe outcomes defined by hospitalizations (median: 33, IQR: 27.25-44). These findings showcase how helpline call monitoring, using time series anomaly detection, can aid early outbreak detection.

Lighting Up Arginine Metabolism Dynamics in Neural Differentiation through Ratiometric Fluorescence Imaging