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Urban park restorative effects in an integrated model of positive emotion and leisure involvement moderation
Abstract Urban parks are critical spaces for residents to alleviate stress and restore psychological well-being. To investigate the differential impact mechanisms of built and natural environments on residents’ restorative effects and their psychological moderating pathways, this study utilizes the survey data from five urban parks in Chengdu, and applies the questionnaire survey method to analyze the mechanism and contextual conditions of the role of different environmental types on the restorative effects of residents through hierarchical linear regression. It further analyzes the moderating effects of residents’ positive emotion and leisure involvement in the above process; and provides empirical reference value for constructing urban leisure scenes with high restorative effects. The result show that in the influence process of built environment to restorative effect, the moderating effect of leisure involvement is greater than positive emotion. While in the influence process of natural environment to restorative effect, the moderating effect of positive emotion and leisure involvement are similar. Both built environment and natural environment can positively influence the residents’ restorative effect. Residents’ positive emotion and leisure involvement have positive moderating effects on this influence process. The results of this research can be a reference to create an urban recreational environment with restorative effect.
Biomechanical strategies to achieve faster running speeds on level ground, uphill and downhill grades
Enhancing software effort estimation with random forest tuning and adaptive decision strategies
Chemometric and predictive modeling of long term cannabinoid transformation in stored Cannabis sativa resin
Recognition of PRI modulation using an optimized convolutional neural network with a gray wolf optimization based on internet protocol and optimal extreme learning machine
Metabolic profiles of squamous cell lung carcinoma and diagnostic model construction
A unified framework to explore soliton boundary interaction using topological magnetic soliton spring oscillators
Abstract Soliton-boundary interactions significantly influence the dynamics, stability, and functionality of topological magnetic solitons in spintronic devices, yet quantifying these interactions remains challenging. In this work, we introduce a unified framework termed the “topological magnetic soliton spring oscillator”, designed to systematically explore and quantify soliton-boundary interactions across different soliton types, including hopfions, skyrmions, and domain walls. Within this framework, soliton motion is governed by the competition between two effective forces: the spin-transfer torque-induced driving force, and the boundary-induced repulsive force, which mainly arises from excess exchange energy near boundaries. Through comprehensive micromagnetic simulations, we reveal that the interaction behavior transitions between linear and nonlinear regimes, depending on the degree of soliton deformation and the value of the damping factor. Specifically, for zero damping (α = 0), when the soliton deformation is minimal, the interaction energy exhibits a linear dependence on coordinates, while significant deformation induces nonlinearity with a slope increasing toward boundaries. For small damping factors, solitons exhibit damped oscillations with velocity-dependent, multivalued interaction energy. At larger damping, overdamped dynamics dominate, characterized by nonlinear interactions with a decreasing slope as the boundary is approached. This framework not only provides a physical basis for interpreting soliton-boundary behavior in topological magnetic systems but also identifies key dynamical features relevant to the design of soliton-based spintronic devices.
Insights from meta-analysis and experimental validation identify exosomal miR-146a-5p as a potential biomarker for sporadic amyotrophic lateral sclerosis
Vitamin B17 alleviates Sorafenib-induced cardiotoxicity in Ehrlich Ascites Carcinoma mice via modulation of inflammatory and fibrotic pathways
Assessment of soil amplification effects on the seismic vulnerability of irregular reinforced concrete buildings of varying heights
Abstract Earthquakes pose a significant threat to structures in seismically active regions. It is, therefore, important to understand the factors that influence the vulnerability of buildings. The seismic performance of buildings is significantly influenced by soil amplification, which depends upon the soil type and ground motion characteristics. In addition, building height and geometric configuration, especially for asymmetric structures such as L-shaped buildings, play a crucial role due to the different stiffness, flexibility, and torsional effects. This present study investigates the impact of soil amplification and ground motion characteristics on the seismic vulnerability of unsymmetrical L-shaped buildings of varying heights by considering five different soil profiles (3 homogeneous and 2 layered) and five different ground motions (two far-field and three near-field). Reinforced concrete moment-resisting frame buildings exhibit significant nonlinear behavior under strong seismic excitation, which must be accurately captured to assess their seismic performance. In this study, the pushover and time history analysis have been performed to estimate the seismic response of the building in terms of base shear, roof displacement, and demand ductility. Finally, fragility analysis has been conducted to estimate the probability of damage, damage index, seismic vulnerability index, and recovery time of the building considering the amplified ground motion effects caused by various soil profiles. The analysis reveals that near-field ground motions significantly amplify ground motion which results in increased roof displacement values (up to 211%), collapse damage (up to 37%), damage index (up to 162%), seismic vulnerability index (up to 189%) and recovery time (up to 383 days) of the building compared to far-field motions. Soil amplification effects are most significant in low-rise buildings, while with increasing building height of unsymmetrical, vulnerability rises due to torsional effects. Layered soil profiles in Silchar and Turkey increase the vulnerability of low-rise buildings, whereas homogeneous clay soil poses greater risks for high-rise buildings. This study highlights the need for Indian Standard (IS) codes to incorporate soil-specific amplification factors and building height considerations, offering practical recommendations to improve seismic design practices for unsymmetrical buildings.
An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function
Abstract GTPase-activating proteins are important regulators of small GTPases; among these, ASAP1 stimulates GTP hydrolysis on Arf1 and is implicated in cancer progression. ASAP1 contains a Pleckstrin Homology (PH) domain essential for maximum Arf·GTP hydrolysis. The prevailing view of PH domains is that they regulate proteins through passive mechanisms like membrane recruitment. In sharp contrast, we show that the PH domain of ASAP1 actively contributes to Arf1 GTP hydrolysis. By combining NMR, molecular dynamics simulations, kinetic assays, and mutational analysis, we find that the PH domain binds Arf·GTP at the membrane, to establish an active state primed for GTP hydrolysis. We identify key residues on the PH domain and Arf that drive this allosteric mechanism, which mathematical modeling shows contributes as much to GTPase activation as membrane recruitment. The finding that PH domains directly modulate small GTPases has broad implications for the Ras and Rho oncoprotein families.